发明授权
US07816349B2 Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
失效
取代的吡咯烷酮作为11-β-羟基类固醇脱氢酶1的抑制剂
- 专利标题： Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
- 专利标题（中）： 取代的吡咯烷酮作为11-β-羟基类固醇脱氢酶1的抑制剂
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申请号： US12297969申请日： 2007-04-23
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公开(公告)号： US07816349B2公开(公告)日： 2010-10-19
- 发明人: John Gordon Allen , Alexei Pavlovych Krasutsky , Owen Brendan Wallace , Yanping Xu , Jeremy Schulenburg York
- 申请人： John Gordon Allen , Alexei Pavlovych Krasutsky , Owen Brendan Wallace , Yanping Xu , Jeremy Schulenburg York
- 申请人地址： US IN Indianapolis
- 专利权人： Eli Lilly and Company
- 当前专利权人： Eli Lilly and Company
- 当前专利权人地址： US IN Indianapolis
- 代理商 Dan L. Wood
- 国际申请： PCT/US2007/067200 WO 20070423
- 国际公布： WO2007/127693 WO 20071108
- 主分类号： A61K31/54
- IPC分类号： A61K31/54 ; A61K31/535 ; A61K31/445 ; A61K31/497 ; C07D401/10 ; C07D403/10 ; C07D413/10 ; C07D417/10
摘要：
The present invention discloses novel compounds of Formula I: (I) possessing 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11β-HSD type 1 activity.
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