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发明授权
US07985857B2 Usage of poly-3-hydroxybutyrates in preparation of β-lactam compounds 有权
聚-3-羟基丁酸酯在制备β-内酰胺化合物中的用途

Usage of poly-3-hydroxybutyrates in preparation of β-lactam compounds
摘要：
A method for preparing compounds having the formula(I) by using P(3HB), wherein R is R1, R2, R3 are lower linear or branched C1-C4 alkyl, comprising the steps of: a: obtaining (3R)-3-RO—CH(CH3)CH2COOCH3 by pyrolysis of P(3HB) and protection; b: obtaining (3R)-3-RO—CH(CH3)CH2CHO by reduction of (3R)-3-RO—CH(CH3)CH2COOCH3 ; c: enolizing (3R)-3-RO—CH(CH3)CH2CHO and then reacting with chlorosulfonyl isocyanate, at last getting the final product by reduction; wherein (3R)-3-RO—CH(CH3)CH2CHO is enolized by reacting (3R)-3-RO—CH(CH3)CH2CHO with isopropenyl acetate and p-toluenesulfonic acid by heating under reflux.
摘要（中）：

通过使用P（3HB）制备具有式（I）的化合物的方法，其中R为R 1，R 2，R 3为低级直链或支链C 1 -C 4烷基，包括以下步骤：a：获得（3R）-3- RO-CH（CH3）CH2COOCH3通过热解P（3HB）和保护; b：通过还原（3R）-3 -OR-CH（CH3）CH2COOCH3获得（3R）-3 -OR-CH（CH 3）CH 2 CHO; c：烯化（3R）-3 -OR-CH（CH 3）CH 2 CHO，然后与氯磺酰基异氰酸酯反应，最后通过还原得到最终产物; 其中通过在回流下加热使（3R）-3 -OR-CH（CH 3）CH 2 CHO与乙酸异丙烯酯和对甲苯磺酸反应来使（3R）-3 -OR-CH（CH 3）CH 2 CHO烯醇化。

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