PHOTOACOUSTIC CATHETER AND IMAGING SYSTEM USING SAME

    公开(公告)号:US20190216330A1

    公开(公告)日:2019-07-18

    申请号:US15998889

    申请日:2017-02-13

    摘要: A photoacoustic catheter includes an elongated catheter body and a housing positioned near a distal end of the elongated catheter body. A length of multimode fiber extends through the elongated catheter body and has a distal end that is beveled at about 45° relative to a longitudinal axis of the multimode fiber and is positioned in the housing. An ultrasonic transducer, electrically connected to an electrical wire extending along the elongated catheter body, is positioned within the housing. A mirror element is also positioned within the housing and includes a mirror surface beveled at about 45° relative to the longitudinal axis of the multimode fiber. The catheter is operable to deliver an optical wave through the multimode fiber and to deliver an ultrasonic wave collinearly from the housing and out of an aperture of the housing to obtain optical data and ultrasonic data within a mammalian luminal organ.

    VIBRATIONAL PHOTOACOUSTIC TOMOGRAPHY USING RAMAN LASER
    3.
    发明申请
    VIBRATIONAL PHOTOACOUSTIC TOMOGRAPHY USING RAMAN LASER 有权
    使用拉曼激光的振动光电图像

    公开(公告)号:US20140200434A1

    公开(公告)日:2014-07-17

    申请号:US14156946

    申请日:2014-01-16

    申请人: Ji-Xin Cheng

    发明人: Ji-Xin Cheng

    IPC分类号: A61B5/00

    CPC分类号: A61B5/0095

    摘要: A method of noninvasively imaging tissue within a body includes irradiating the tissue using an imaging laser including a Raman-based laser tuner, the radiation including a plurality of laser pulses, each having energy greater than 100 mJ; receiving an acoustic signal generated by vibrational energy in the tissue, wherein the vibrational energy is a result of selective overtone excitation of molecules in the tissue by the radiation; and automatically converting the acoustic signal to an image representative of the tissue using a processor. An imaging system includes an imaging laser configured to irradiate tissue with a plurality of laser pulses using a Raman-based laser tuner. An ultrasonic transducer receives an acoustic signal generated by vibrational energy in the tissue due to overtone excitation by the radiation. A processor is configured to automatically produce an image representative of the tissue using the received acoustic signal.

    摘要翻译: 一种在体内非侵入性地成像组织的方法包括使用包括基于拉曼的激光调谐器的成像激光器照射组织,该辐射包括多个激光脉冲,每个激光脉冲具有大于100mJ的能量; 接收由所述组织中的振动能产生的声信号,其中所述振动能是由所述辐射对所述组织中的分子的选择性泛音激励的结果; 并使用处理器自动地将声信号转换成代表组织的图像。 一种成像系统包括:成像激光器,被配置为使用基于拉曼的激光调谐器来照射具有多个激光脉冲的组织。 超声换能器由于辐射的泛音激励而接收由组织中的振动能产生的声信号。 处理器被配置为使用所接收的声信号自动产生代表组织的图像。

    NANOMEDICINES FOR EARLY NERVE REPAIR
    4.
    发明申请
    NANOMEDICINES FOR EARLY NERVE REPAIR 审中-公开
    用于早期神经修复的纳米酮

    公开(公告)号:US20130337075A1

    公开(公告)日:2013-12-19

    申请号:US14001189

    申请日:2012-02-24

    申请人: Ji-Xin Cheng

    发明人: Ji-Xin Cheng

    IPC分类号: A61K47/48 A61K45/06

    摘要: The present disclosure describes hydrophobically modified nanoparticles and polymeric nanostructures that can be utilized to for the treatment of neuronal injury or neuronal disease in an affected patient, along with methods of forming and using the nanoparticles and nanostructures. Furthermore, the nanoparticles and nanostructures are designed as “dual action” compositions to treat neuronal injury and neuronal disease via repair of damaged membrane and suppression of intracellular inflammation.

    摘要翻译: 本公开内容描述了可用于治疗受影响患者的神经元损伤或神经元疾病的疏水改性的纳米颗粒和聚合物纳米结构,以及形成和使用纳米颗粒和纳米结构的方法。 此外,纳米颗粒和纳米结构被设计为“双作用”组合物,通过修复受损膜并抑制细胞内炎症来治疗神经元损伤和神经元疾病。

    System and method for epi-detected coherent anti-stokes raman scattering microscopy
    5.
    发明授权
    System and method for epi-detected coherent anti-stokes raman scattering microscopy 有权
    用于epi检测的相干反火箭拉曼散射显微镜的系统和方法

    公开(公告)号:US06809814B2

    公开(公告)日:2004-10-26

    申请号:US10345677

    申请日:2003-01-16

    IPC分类号: G01J344

    摘要: Systems and methods are disclosed for detecting a coherent anti-Stokes Raman scattering (CARS) signal from a microscopic sample in an epi-direction. In an embodiment, the system includes at least two sources having a pump source for generating a pump field at the pump frequency, a Stoke source for generating a Stoke field at the Stoke frequency that is different from the pump frequency, optics (64) for directing the pump and Stoke beams (60) in a collinear fashion through a focusing lens (66) toward a common focal spot in a sample (70), and detector optics that images the CARS in epi-direction, which is generated by the interaction of the pump and Stoke fields (60) with the sample (70) and is collected by the same focusing lens (66), towards an epi-detector (78).

    摘要翻译: 公开了用于从表面方向检测来自微观样品的相干反斯托克斯拉曼散射(CARS)信号的系统和方法。 在一个实施例中,该系统包括至少两个源,其具有用于产生泵频率的泵浦场的泵浦源,用于产生Stoke频率不同于泵浦频率的Stoke场的Stoke源,用于 将泵和Stoke梁(60)以共线的方式通过聚焦透镜(66)朝向样品(70)中的公共焦斑引导,以及检测器光学器件,其通过相互作用产生的外延方向成像CARS 的泵和Stoke磁场(60)与样品(70)并且被相同的聚焦透镜(66)收集到外部探测器(78)。

    Wavelength-division-multiplexed optical transmission system with expanded bidirectional transmission capacity over a single fiber
    6.
    发明授权
    Wavelength-division-multiplexed optical transmission system with expanded bidirectional transmission capacity over a single fiber 失效
    波分复用光传输系统,通过单个光纤扩展双向传输容量

    公开(公告)号:US06400478B1

    公开(公告)日:2002-06-04

    申请号:US09054287

    申请日:1998-04-02

    IPC分类号: H04J1402

    CPC分类号: H04B10/2503 H04J14/02

    摘要: The present invention provides an expandable and cost-effective high capacity optical communication system using wavelength-division-multiplexing, optical direction guide means and bidirectional transmission of data over an optical waveguide. The use of interleaved bidirectional data channels reduces the minimum spacing between data channels, permitting a greater number of channels over a single optical waveguide.

    摘要翻译: 本发明提供了一种使用波分复用,光学方向引导装置和通过光波导的数据的双向传输的可扩展和成本有效的大容量光通信系统。 使用交错的双向数据信道减少数据信道之间的最小间隔,允许在单个光波导上的更多数量的信道。

    Apparatus for processing multiple types of graphics data for display
    7.
    发明授权
    Apparatus for processing multiple types of graphics data for display 失效
    用于处理多种类型的图形数据进行显示的装置

    公开(公告)号:US5943064A

    公开(公告)日:1999-08-24

    申请号:US972461

    申请日:1997-11-15

    摘要: A controller card is provided that allows the processing and display of two types of graphics pixel data for display in two environments. The card contains a first graphics controller chip coupled to the video capture port of a second graphics controller chip. In a first mode the first chip may generate graphics pixel data for display in a first environment. The pixel data is stored in the memory of the second chip reserved for graphics pixel data and transmitted to a display device coupled to the second chip. In a second mode, the video capture port may be coupled to a video source so that data captured in the video port is stored in the memory of the chip reserved for video pixel data. The second chip may then process and output to the display device both video pixel data and a second type of graphics pixel data generated by the second chip and stored in the memory of the second chip reserved for graphics pixel data.

    摘要翻译: 提供了一种控制器卡,其允许处理和显示两种类型的图形像素数据以在两个环境中显示。 该卡包含耦合到第二图形控制器芯片的视频捕获端口的第一图形控制器芯片。 在第一模式中,第一芯片可以生成用于在第一环境中显示的图形像素数据。 像素数据被存储在为图形像素数据保留的第二芯片的存储器中,并被发送到耦合到第二芯片的显示装置。 在第二模式中,视频捕获端口可以耦合到视频源,使得在视频端口中捕获的数据被存储在为视频像素数据保留的芯片的存储器中。 然后,第二芯片可以处理并输出视频像素数据和由第二芯片产生的第二类型的图形像素数据并将其存储在为图形像素数据保留的第二芯片的存储器中。

    Bias control and method for electro-optic modulators
    8.
    发明授权
    Bias control and method for electro-optic modulators 失效
    电光调制器的偏置控制和方法

    公开(公告)号:US5343324A

    公开(公告)日:1994-08-30

    申请号:US794719

    申请日:1991-11-15

    申请人: Phat Le Xin Cheng

    发明人: Phat Le Xin Cheng

    CPC分类号: G02F1/0123 G02F2001/212

    摘要: An electro-optical modulation system comprising an optical modulator for pulse-modulating an incoming light beam in response to a pulsed RF input signal and to a bias signal and for producing a pulse-modulated optical output which is characterized by a plurality of enveloped pulses, optical detector for producing an electrical signal which is representative of the output from the optical modulator, average detecting device for producing pulse envelope signals which are representative of the envelopes of the pulses, and a bias control circuit, using a plurality of pulse envelop signals, for producing the bias signal as a function of the pulse envelopes.

    摘要翻译: 一种电光调制系统,包括用于响应于脉冲RF输入信号和偏置信号脉冲调制入射光束并用于产生以多个包络脉冲为特征的脉冲调制光输出的光调制器, 用于产生表示来自光调制器的输出的电信号的光学检测器,用于产生表示脉冲包络的脉冲包络信号的平均检测装置,以及使用多个脉冲包络信号的偏置控制电路, 用于产生作为脉冲包络的函数的偏置信号。