发明授权
- 专利标题： Cationic lipid-mediated enhancement of nucleic acid immunization of cats
- 专利标题（中）： 阳离子脂质介导的猫的核酸免疫增强
-
申请号： US11866558申请日： 2007-10-03
-
公开(公告)号： US08029776B2公开(公告)日： 2011-10-04
- 发明人: Joel R. Haynes , Ramani S. Wonderling , Dan T. Stinchcomb
- 申请人： Joel R. Haynes , Ramani S. Wonderling , Dan T. Stinchcomb
- 申请人地址： US CO Loveland
- 专利权人： Heska Corporation
- 当前专利权人： Heska Corporation
- 当前专利权人地址： US CO Loveland
- 主分类号： A61K39/21
- IPC分类号： A61K39/21 ; C07H23/00 ; A61K48/00
摘要：
The present invention relates to a method to introduce a nucleic acid molecule into a felid by administration of a nucleic acid-cationic lipid complex composition. The method includes the step of administering to the felid, by a parenteral route, a nucleic acid-cationic lipid complex to elicit and/or enhance an immune response. In one embodiment, this method enhances the immune response in a felid compared to a method in which a naked DNA vaccine is administered to a felid. Also provided is a method to deliver a nucleic acid to a felid. This method comprises parenterally administering to the felid a composition that includes a nucleic acid molecule complexed with a cationic lipid.