-
公开(公告)号：US09439959B2
公开(公告)日：2016-09-13
申请号：US12375376
申请日：2007-07-27
申请人： Joel R. Haynes
发明人： Joel R. Haynes
IPC分类号： A61K39/145 , A61K39/12 , C07K14/005 , A61K39/385 , A61K39/39 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K39/385 , A61K39/39 , A61K2039/5258 , A61K2039/543 , A61K2039/55516 , A61K2039/55572 , A61K2039/55583 , A61K2039/58 , A61K2039/6068 , A61K2039/6075 , C07K14/005 , C07K2319/735 , C12N2740/10022 , C12N2740/13022 , C12N2740/13023 , C12N2740/16122 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： Chimeric Influenza virus-like particles including gag polypeptides are described. Virus-like particles are generated with a gag polypeptide, a neuraminidase polypeptide and optionally a hemagglutinin polypeptide. Preferred methods of generation include expression in insect cells.
摘要翻译： 描述了嵌合流感病毒样颗粒，包括gag多肽。 用gag多肽，神经氨酸酶多肽和任选的血凝素多肽产生病毒样颗粒。 优选的产生方法包括在昆虫细胞中的表达。
-
2.发明申请METHODS FOR STABILIZING INFLUENZA ANTIGEN ENVELOPED VIRUS-BASED VIRUS-LIKE PARTICLE SOLUTIONS 审中-公开稳定流感病毒抗原基于病毒的病毒样颗粒溶液的方法公开(公告)号：US20130028933A1
公开(公告)日：2013-01-31
申请号：US13517240
申请日：2010-12-28
申请人： Joel R. Haynes , Bryan Steadman
发明人： Joel R. Haynes , Bryan Steadman
IPC分类号： C07K1/02 , A61P31/16 , A61P37/04 , A61K39/145 , C07K14/11
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5258 , C07K14/005 , C12N7/00 , C12N2710/14143 , C12N2740/13051 , C12N2760/16122 , C12N2760/16123 , C12N2760/16151
摘要： Methods of stabilizing solutions with enveloped vims-based virus-like particles containing an influenza antigen and such stabilized solutions are described.
摘要翻译： 描述了用包含流感抗原的包膜的基于vims的病毒样颗粒稳定溶液的方法和这种稳定的溶液。
-
3.发明授权公开(公告)号：US08029776B2
公开(公告)日：2011-10-04
申请号：US11866558
申请日：2007-10-03
CPC分类号： A61K39/205 , A61K39/0005 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/6018 , C12N2760/20134
摘要： The present invention relates to a method to introduce a nucleic acid molecule into a felid by administration of a nucleic acid-cationic lipid complex composition. The method includes the step of administering to the felid, by a parenteral route, a nucleic acid-cationic lipid complex to elicit and/or enhance an immune response. In one embodiment, this method enhances the immune response in a felid compared to a method in which a naked DNA vaccine is administered to a felid. Also provided is a method to deliver a nucleic acid to a felid. This method comprises parenterally administering to the felid a composition that includes a nucleic acid molecule complexed with a cationic lipid.
摘要翻译： 本发明涉及通过施用核酸 - 阳离子脂质复合物组合物将核酸分子引入纤毛蛋白的方法。 该方法包括通过肠胃外途径向核蛋白施用核酸 - 阳离子脂质复合物以引发和/或增强免疫应答的步骤。 在一个实施方案中，与将裸DNA疫苗施用于felid的方法相比，该方法增强了felid中的免疫应答。 还提供了将核酸递送至felid的方法。 该方法包括肠胃外施用包含与阳离子脂质复合的核酸分子的组合物。
-
公开(公告)号：US20100047266A1
公开(公告)日：2010-02-25
申请号：US12375281
申请日：2007-07-27
申请人： Joel R. Haynes
发明人： Joel R. Haynes
IPC分类号： A61K39/12 , C07K14/005 , C12N9/96 , C07H21/04
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/385 , A61K39/39 , A61K2039/5258 , A61K2039/543 , A61K2039/55516 , A61K2039/55544 , A61K2039/55572 , A61K2039/6068 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2319/735 , C12N2740/13022 , C12N2740/13023 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/18522 , C12N2760/18534 , C12N2770/16022 , C12N2770/16034 , C12N2810/6072
摘要： Chimeric virus-like particles including gag polypeptides are described. Virus-like particles are generated with a gag polypeptide and lipid raft-associated polypeptide linked to an antigen that is not naturally associated with a lipid raft. Preferred methods of generation include expression in insect cells.
摘要翻译： 描述包括gag多肽的嵌合病毒样颗粒。 病毒样颗粒是与一种不与天然与脂筏相关的抗原连接的gag多肽和脂筏相关多肽产生的。 优选的产生方法包括在昆虫细胞中的表达。
-
公开(公告)号：US07223739B1
公开(公告)日：2007-05-29
申请号：US09433777
申请日：1999-11-03
申请人： Joel R. Haynes , Georg Widera , James T. Fuller , Timothy Shipley , Deborah Fuller , Mary Wu
发明人： Joel R. Haynes , Georg Widera , James T. Fuller , Timothy Shipley , Deborah Fuller , Mary Wu
CPC分类号： A61K33/24 , A61K39/0011 , A61K39/015 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/292 , A61K45/06 , A61K2039/53 , A61K2039/545 , A61K2039/55572 , A61K2039/55577 , A61K2039/57 , C07K14/005 , C12N15/895 , C12N2730/10122 , C12N2740/16122 , C12N2740/16134 , C12N2760/16122 , C12N2760/16134 , Y02A50/412
摘要： Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for inducing an enhanced immune response against a selected antigen.
摘要翻译： 描述了可用于核酸免疫技术的试剂。 更具体地，描述了佐剂化的遗传疫苗组合物，以及使用这些组合物诱导针对所选抗原的增强的免疫应答的方法。
-
公开(公告)号：US20120093855A1
公开(公告)日：2012-04-19
申请号：US13140817
申请日：2009-11-18
申请人： Joel R. Haynes
发明人： Joel R. Haynes
IPC分类号： A61K39/12 , A61P31/12 , A61P37/02 , C12P21/06 , C07K14/005
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5258 , A61K2039/555 , C12N2760/18523 , C12N2760/18534
摘要： The present invention relates to the field of isolation of enveloped virus-based virus-like particles (VLPs) free of infectious agents. In preferred examples, the field includes methods of inactivation of infectious agents that do not adversely affect the immunogenicity of the enveloped virus-based VLPs. In certain embodiments, the enveloped virus-based VLPs are produced in insect cell based expression systems.
摘要翻译： 本发明涉及分离不含感染因子的基于病毒的病毒样颗粒（VLPs）的领域。 在优选的实施例中，该领域包括不影响基于包膜病毒的VLP的免疫原性的感染剂灭活的方法。 在某些实施方案中，基于昆虫细胞的表达系统产生基于病毒的包膜的VLP。
-
7.发明申请METHODS FOR ISOLATING ENVELOPED VIRUS-BASED VLPS FREE OF INFECTIOUS AGENTS 审中-公开用于分离无基因病毒的基于病毒的VLPS的方法公开(公告)号：US20110262483A1
公开(公告)日：2011-10-27
申请号：US13127411
申请日：2009-11-03
申请人： Joel R. Haynes , Ross Taylor
发明人： Joel R. Haynes , Ross Taylor
IPC分类号： A61K39/155 , A61P37/04 , A61P31/14 , C12N15/866 , A61K39/12
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K41/0019 , A61K2039/5252 , A61K2039/5258 , A61K2039/55572 , A61K2039/58 , C12N2710/14143 , C12N2740/13022 , C12N2760/16051 , C12N2760/16123 , C12N2760/16134 , C12N2760/16151
摘要： Enveloped virus-based virus-like particles (VLPs) that are free of infectious agents and substantially as immunogenic as corresponding VLPs prior to inactivation of infectious agents are described. Improved methods of inactivation infectious agents in preparations of enveloped virus-based VLPs are also described wherein the methods do not adversely affect the immunogenicity of the VLPs.
摘要翻译： 描述了在感染性试剂失活之前没有感染因子并且基本上与对应的VLP一样具有免疫原性的包膜的基于病毒的病毒样颗粒（VLP）。 还描述了在包封的基于病毒的VLP的制剂中灭活感染性试剂的改进方法，其中所述方法不会不利地影响VLP的免疫原性。
-
8.发明申请公开(公告)号：US20090060948A1
公开(公告)日：2009-03-05
申请号：US11866558
申请日：2007-10-03
IPC分类号： A61K39/00 , A61K31/7088 , A61P31/00
CPC分类号： A61K39/205 , A61K39/0005 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/6018 , C12N2760/20134
摘要： The present invention relates to a method to introduce a nucleic acid molecule into a fetid by administration of a nucleic acid-cationic lipid complex composition. The method includes the step of administering to the felid, by a parenteral route, a nucleic acid-cationic lipid complex to elicit and/or enhance an immune response. In one embodiment, this method enhances the immune response in a fetid compared to a method in which a naked DNA vaccine is administered to a felid. Also provided is a method to deliver a nucleic acid to a felid. This method comprises parenterally administering to the fetid a composition that includes a nucleic acid molecule complexed with a cationic lipid.
摘要翻译： 本发明涉及通过施用核酸 - 阳离子脂质复合物组合物将核酸分子引入胎儿的方法。 该方法包括通过肠胃外途径向核蛋白施用核酸 - 阳离子脂质复合物以引发和/或增强免疫应答的步骤。 在一个实施方案中，与将裸DNA疫苗施用于felid的方法相比，该方法增强了胎儿中的免疫应答。 还提供了将核酸递送至felid的方法。 该方法包括向胎儿肠胃外施用包含与阳离子脂质复合的核酸分子的组合物。
-
公开(公告)号：US20090017527A1
公开(公告)日：2009-01-15
申请号：US11752173
申请日：2007-05-22
申请人： Joel R. HAYNES , Georg Widera , James T. Fuller , Timothy Shipley , Deborah Fuller , Mary Wu
发明人： Joel R. HAYNES , Georg Widera , James T. Fuller , Timothy Shipley , Deborah Fuller , Mary Wu
IPC分类号： C12M1/00
CPC分类号： A61K33/24 , A61K39/0011 , A61K39/015 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/292 , A61K45/06 , A61K2039/53 , A61K2039/545 , A61K2039/55572 , A61K2039/55577 , A61K2039/57 , C07K14/005 , C12N15/895 , C12N2730/10122 , C12N2740/16122 , C12N2740/16134 , C12N2760/16122 , C12N2760/16134 , Y02A50/412
摘要： Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for inducing an enhanced immune response against a selected antigen.
摘要翻译： 描述了可用于核酸免疫技术的试剂。 更具体地，描述了佐剂化的遗传疫苗组合物，以及使用这些组合物诱导针对所选抗原的增强的免疫应答的方法。
-
10.发明授权公开(公告)号：US07314627B2
公开(公告)日：2008-01-01
申请号：US10864903
申请日：2004-06-09
IPC分类号： A61K39/00 , A61K39/12 , A61K39/39 , A61K39/205 , A61K31/7088 , C07H21/00 , C12N15/00
CPC分类号： A61K39/205 , A61K39/0005 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/6018 , C12N2760/20134
摘要： The present invention relates to a method to introduce a nucleic acid molecule into a felid by administration of a nucleic acid-cationic lipid complex composition. The method includes the step of administering to the felid, by a parenteral route, a nucleic acid-cationic lipid complex to elicit and/or enhance an immune response. In one embodiment, this method enhances the immune response in a felid compared to a method in which a naked DNA vaccine is administered to a felid. Also provided is a method to deliver a nucleic acid to a felid. This method comprises parenterally administering to the felid a composition that includes a nucleic acid molecule complexed with a cationic lipid.
摘要翻译： 本发明涉及通过施用核酸 - 阳离子脂质复合物组合物将核酸分子引入纤毛蛋白的方法。 该方法包括通过肠胃外途径向核蛋白施用核酸 - 阳离子脂质复合物以引发和/或增强免疫应答的步骤。 在一个实施方案中，与将裸DNA疫苗施用于felid的方法相比，该方法增强了felid中的免疫应答。 还提供了将核酸递送至felid的方法。 该方法包括肠胃外施用包含与阳离子脂质复合的核酸分子的组合物。
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.024 秒)