发明授权
- 专利标题: Compounds and methods of use
- 专利标题(中): 化合物和使用方法
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申请号: US12641063申请日: 2009-12-17
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公开(公告)号: US08114893B2公开(公告)日: 2012-02-14
- 发明人: Jonathan Bayldon Baell , Chinh Thien Bui , Peter Colman , Danette A. Dudley , Wayne J. Fairbrother , John A. Flygare , Guillaume Laurent Lessene , Chudi Ndubaku , George Nikolakopoulos , Carl Steven Rye , Brad Edmund Sleebs , Brian John Smith , Keith Geoffrey Watson , Steven W. Elmore , Andrew M. Petros , Andrew J. Souers , Peter Czabotar
- 申请人: Jonathan Bayldon Baell , Chinh Thien Bui , Peter Colman , Danette A. Dudley , Wayne J. Fairbrother , John A. Flygare , Guillaume Laurent Lessene , Chudi Ndubaku , George Nikolakopoulos , Carl Steven Rye , Brad Edmund Sleebs , Brian John Smith , Keith Geoffrey Watson , Steven W. Elmore , Andrew M. Petros , Andrew J. Souers , Peter Czabotar
- 申请人地址: US CA South San Francisco US IL Abbott Park AU Parkville
- 专利权人: Genentech, Inc.,Abbott Laboratories,The Walter and Eliza Hall Medical Research Institute
- 当前专利权人: Genentech, Inc.,Abbott Laboratories,The Walter and Eliza Hall Medical Research Institute
- 当前专利权人地址: US CA South San Francisco US IL Abbott Park AU Parkville
- 代理机构: Jones Day
- 主分类号: C07D417/14
- IPC分类号: C07D417/14 ; A61K31/5377 ; A61K31/538 ; A61K31/496 ; A61K31/498 ; A61K31/4709
摘要:
In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.
公开/授权文献
- US20100190782A1 COMPOUNDS AND METHODS OF USE 公开/授权日:2010-07-29