发明授权
US08137953B2 Lactic acid-producing yeast cells having nonfunctional L- or D-lactate:ferricytochrome C oxidoreductase cells
有权
具有非功能性L-或D-乳酸的产酸酵母细胞：铁染色质C氧化还原酶细胞
- 专利标题： Lactic acid-producing yeast cells having nonfunctional L- or D-lactate:ferricytochrome C oxidoreductase cells
- 专利标题（中）： 具有非功能性L-或D-乳酸的产酸酵母细胞：铁染色质C氧化还原酶细胞
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申请号： US12093757申请日： 2006-11-17
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公开(公告)号： US08137953B2公开(公告)日： 2012-03-20
- 发明人: Matthew Miller , Pirkko Suominen , Aristos Aristidou , Benjamin Matthew Hause , Pim Van Hoek , Catherine Asleson Dundon
- 申请人： Matthew Miller , Pirkko Suominen , Aristos Aristidou , Benjamin Matthew Hause , Pim Van Hoek , Catherine Asleson Dundon
- 申请人地址： US MN Wayzata
- 专利权人： Cargill Inc.
- 当前专利权人： Cargill Inc.
- 当前专利权人地址： US MN Wayzata
- 代理商 Gary C Cohn PLLC
- 国际申请： PCT/US2006/044815 WO 20061117
- 国际公布： WO2007/117282 WO 20071018
- 主分类号： C12N1/19
- IPC分类号： C12N1/19 ; C12N1/00 ; C12N15/70 ; C12Q1/68
摘要：
Yeast cells having an exogenous lactate dehydrogenase gene ae modified by reducing L- or D-lactate:ferricytochrome c oxidoreductase activity in the cell. This leads to reduced consumption of lactate by the cell and can increase overall lactate yields in a fermentation process. Cells having the reduced L- or D-lactate:ferricytochrome c oxidoreductase activity can be screened for by resistance to organic acids such as lactic or glycolic acid.
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