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1.发明申请Lactic Acid-Producing Yeast Cells Having Nonfunctional L- or D-Lactate:Ferricytochrome C Oxidoreductase Cells 有权具有非功能性L-或D-乳酸的乳酸生产酵母细胞：铁染色质C氧化还原酶细胞公开(公告)号：US20090253189A1
公开(公告)日：2009-10-08
申请号：US12093757
申请日：2006-11-17
申请人： Matthew Miller , Pirkko Suominen , Aristos Aristidou , Benjamin Matthew Hause , Pim Van Hoek , Catherine Asleson Dundon
发明人： Matthew Miller , Pirkko Suominen , Aristos Aristidou , Benjamin Matthew Hause , Pim Van Hoek , Catherine Asleson Dundon
CPC分类号： C12N9/0006 , C12P7/56 , C12Y101/02003
摘要： Yeast cells having an exogenous lactate dehydrogenase gene ae modified by reducing L- or D-lactate:ferricytochrome c oxidoreductase activity in the cell. This leads to reduced consumption of lactate by the cell and can increase overall lactate yields in a fermentation process. Cells having the reduced I, or D-lactate:ferricytochrome c oxidoreductase activity can be screened for by resistance to organic acids such as lactic or glycolic acid.
摘要翻译： 酵母细胞具有通过减少细胞中的L-或D-乳酸：铁染色体氧化还原酶活性而修饰的外源性乳酸脱氢酶基因。 这导致细胞对乳酸盐的消耗降低，并且可以增加发酵过程中的总体乳酸盐产量。 具有降低的I或D-乳酸：铁染色质c氧化还原酶活性的细胞可通过耐有机酸如乳酸或乙醇酸进行筛选。
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2.发明授权Lactic acid-producing yeast cells having nonfunctional L- or D-lactate:ferricytochrome C oxidoreductase cells 有权具有非功能性L-或D-乳酸的产酸酵母细胞：铁染色质C氧化还原酶细胞公开(公告)号：US08137953B2
公开(公告)日：2012-03-20
申请号：US12093757
申请日：2006-11-17
申请人： Matthew Miller , Pirkko Suominen , Aristos Aristidou , Benjamin Matthew Hause , Pim Van Hoek , Catherine Asleson Dundon
发明人： Matthew Miller , Pirkko Suominen , Aristos Aristidou , Benjamin Matthew Hause , Pim Van Hoek , Catherine Asleson Dundon
CPC分类号： C12N9/0006 , C12P7/56 , C12Y101/02003
摘要： Yeast cells having an exogenous lactate dehydrogenase gene ae modified by reducing L- or D-lactate:ferricytochrome c oxidoreductase activity in the cell. This leads to reduced consumption of lactate by the cell and can increase overall lactate yields in a fermentation process. Cells having the reduced L- or D-lactate:ferricytochrome c oxidoreductase activity can be screened for by resistance to organic acids such as lactic or glycolic acid.
摘要翻译： 酵母细胞具有通过减少细胞中的L-或D-乳酸：铁染色体氧化还原酶活性而修饰的外源性乳酸脱氢酶基因。 这导致细胞对乳酸盐的消耗降低，并且可以增加发酵过程中的总体乳酸盐产量。 具有降低的L-乳酸或D-乳酸：细胞色素C氧化还原酶活性的细胞可通过耐有机酸如乳酸或乙醇酸进行筛选。
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3.发明申请YEAST CELLS HAVING DISRUPTED PATHWAY FROM DIHYDROXYACETONE PHOSPHATE TO GLYCEROL 审中-公开具有从二羟基乙酸酯磷酸盐到甘油的破坏途径的YEAST细胞公开(公告)号：US20090053782A1
公开(公告)日：2009-02-26
申请号：US12281286
申请日：2007-03-13
申请人： Catherine Asleson Dundon , Pirkko Suominen , Aristos Aristidou , Brian J. Rush , Kari Koivuranta , Benjamin Matthew Hause , Thomas William McMullin , Kevin Roberg-Perez
发明人： Catherine Asleson Dundon , Pirkko Suominen , Aristos Aristidou , Brian J. Rush , Kari Koivuranta , Benjamin Matthew Hause , Thomas William McMullin , Kevin Roberg-Perez
CPC分类号： B65G15/12 , B65G17/12 , C12N15/52 , C12P7/06 , C12P7/40 , C12P7/56 , E01B29/32 , Y02E50/17 , Y10T137/85986
摘要： Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyueromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.
摘要翻译： 酵母细胞被遗传修饰以破坏从二羟基丙酮到甘油的天然代谢途径。 在某些方面，酵母细胞是克鲁维酵母属，假丝酵母属或发chen类。 在其它方面，酵母细胞能够产生至少一种有机酸，如乳酸盐。 酵母细胞比野生型菌株产生明显较少的甘油，并且通常产生更高产量的所需发酵产物。 本发明的酵母细胞在培养时经常生长良好，尽管它们的甘油产量减少。
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公开(公告)号：US20130209507A1
公开(公告)日：2013-08-15
申请号：US13767569
申请日：2013-02-14
CPC分类号： A61K39/15 , A61K38/00 , A61K39/12 , A61K39/21 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55505 , A61K2039/55566 , A61K2039/55577 , A61K2039/70 , C07K14/005 , C07K16/10 , C07K2319/00 , C12N2720/12334
摘要： The present invention provides Rotavirus antigenic polypeptides or antigens that elicit an immune response in animal or human against rotavirus, compositions comprising said rotavirus polypeptides, methods of vaccination against rotavirus, and kits for use with such methods and compositions. The invention further provide novel expression vectors for producing the vaccine antigenic polypeptides.
摘要翻译： 本发明提供了轮状病毒抗原性多肽或抗原，其在动物或人体中引起针对轮状病毒的免疫应答，包含所述轮状病毒多肽的组合物，针对轮状病毒的疫苗接种方法，以及用于此类方法和组合物的试剂盒。 本发明还提供了用于产生疫苗抗原多肽的新型表达载体。
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公开(公告)号：US09446117B2
公开(公告)日：2016-09-20
申请号：US13767569
申请日：2013-02-14
CPC分类号： A61K39/15 , A61K38/00 , A61K39/12 , A61K39/21 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55505 , A61K2039/55566 , A61K2039/55577 , A61K2039/70 , C07K14/005 , C07K16/10 , C07K2319/00 , C12N2720/12334
摘要： The present invention provides Rotavirus antigenic polypeptides or antigens that elicit an immune response in animal or human against rotavirus, compositions comprising said rotavirus polypeptides, methods of vaccination against rotavirus, and kits for use with such methods and compositions. The invention further provide novel expression vectors for producing the vaccine antigenic polypeptides.
摘要翻译： 本发明提供了轮状病毒抗原性多肽或抗原，其在动物或人体中引起针对轮状病毒的免疫应答，包含所述轮状病毒多肽的组合物，针对轮状病毒的疫苗接种方法，以及用于此类方法和组合物的试剂盒。 本发明还提供了用于产生疫苗抗原多肽的新型表达载体。
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