Invention Grant
US08168647B2 Vinblastine derivatives, their preparation, use and pharmaceutical compositions comprising the said derivatives
失效
长春花碱衍生物，它们的制备，用途和包含所述衍生物的药物组合物
- Patent Title: Vinblastine derivatives, their preparation, use and pharmaceutical compositions comprising the said derivatives
- Patent Title (中): 长春花碱衍生物，它们的制备，用途和包含所述衍生物的药物组合物
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Application No.: US12449180Application Date: 2007-12-17
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Publication No.: US08168647B2Publication Date: 2012-05-01
- Inventor: Lihong Hu , Xu Shen , Hualiang Jiang , Liguang Lou , Hong Ding , Yong Shao , Hankun Zhang
- Applicant: Lihong Hu , Xu Shen , Hualiang Jiang , Liguang Lou , Hong Ding , Yong Shao , Hankun Zhang
- Applicant Address: CN Pudong, Shanghai
- Assignee: Shanghai Institute of Materia Medica Chinese Academy of Sciences
- Current Assignee: Shanghai Institute of Materia Medica Chinese Academy of Sciences
- Current Assignee Address: CN Pudong, Shanghai
- Agency: Nixon & Vanderhye P.C.
- International Application: PCT/CN2007/003624 WO 20071217
- International Announcement: WO2008/092335 WO 20080807
- Main IPC: C07D519/04
- IPC: C07D519/04 ; A61K31/475 ; A61P35/00
Abstract:
The invention provides vinblastine derivatives represented by the following formula 1 or their physiologically acceptable salts, their preparation, use and pharmaceutical compositions comprising the said derivatives. The said vinblastine derivatives show inhibiting activities against tumor cell lines and can be used as medicaments for treating malignant tumors.
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