Invention Grant
- Patent Title: Aromatic compounds for suppressing the generation of collagen
- Patent Title (中): 抑制胶原蛋白产生的芳香族化合物
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Application No.: US11659689Application Date: 2005-08-03
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Publication No.: US08188277B2Publication Date: 2012-05-29
- Inventor: Tae Fukushima , Shuji Matsumura , Noriaki Takemura , Hideaki Satou , Nobuaki Ito , Takuya Shitsuta , Hironori Tsutsui , Michinori Tanaka , Keizo Kan , Hitoshi Nagao , Kenji Watanabe , Kuninori Tai , Takashi Nakagawa , Hideki Takasu , Makoto Sakamoto , Keisuke Miyajima , Satoshi Yamada , Yutaka Kojima , Koichi Yasumura , Naoto Ohi , Mitsuhiro Okuno , Kazuhisa Sugiyama , Kunihiko Kiyono , Takashi Suzuki , Seiji Akamatsu , Takeshi Kodama , Yasuo Yanagihara , Takumi Sumida
- Applicant: Tae Fukushima , Shuji Matsumura , Noriaki Takemura , Hideaki Satou , Nobuaki Ito , Takuya Shitsuta , Hironori Tsutsui , Michinori Tanaka , Keizo Kan , Hitoshi Nagao , Kenji Watanabe , Kuninori Tai , Takashi Nakagawa , Hideki Takasu , Makoto Sakamoto , Keisuke Miyajima , Satoshi Yamada , Yutaka Kojima , Koichi Yasumura , Naoto Ohi , Mitsuhiro Okuno , Kazuhisa Sugiyama , Kunihiko Kiyono , Takashi Suzuki , Seiji Akamatsu , Takeshi Kodama , Yasuo Yanagihara , Takumi Sumida
- Applicant Address: JP Tokyo
- Assignee: Otsuka Pharmaceutical Co., Ltd.
- Current Assignee: Otsuka Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- Priority: JP2004-230092 20040806; JP2005-090149 20050325
- International Application: PCT/JP2005/014611 WO 20050803
- International Announcement: WO2006/014012 WO 20060209
- Main IPC: C07D241/36
- IPC: C07D241/36 ; C07D413/12 ; C07D403/12 ; C07D221/02 ; C07D401/12 ; C07D213/62 ; A61K31/535 ; A61K31/497 ; A61K31/445

Abstract:
The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH═; R1 represents a group —Z—R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.
Public/Granted literature
- US20070270422A1 Aromatic Compounds Public/Granted day:2007-11-22
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