公开(公告)号：US08362252B2

公开(公告)日：2013-01-29

申请号：US12611921

申请日：2009-11-03

申请人： Takeshi Kuroda ,  Takahito Yamauchi ,  Tomoichi Shinohara ,  Kunio Oshima ,  Chiharu Kitajima ,  Hitoshi Nagao ,  Tae Fukushima ,  Takahiro Tomoyasu ,  Hironobu Ishiyama ,  Kazuhide Ohta ,  Masaaki Takano ,  Takumi Sumida

发明人： Takeshi Kuroda ,  Takahito Yamauchi ,  Tomoichi Shinohara ,  Kunio Oshima ,  Chiharu Kitajima ,  Hitoshi Nagao ,  Tae Fukushima ,  Takahiro Tomoyasu ,  Hironobu Ishiyama ,  Kazuhide Ohta ,  Masaaki Takano ,  Takumi Sumida

IPC分类号： C07D215/38

CPC分类号： C07D471/08 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04

摘要： The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R4 and R5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R1 is a hydrogen atom, etc; R2 is a hydrogen atom, etc; and R3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

摘要翻译： 本发明提供由通式（1）表示的喹诺酮化合物或其盐，其中A为直接键，低级亚烷基或低级亚烷基; X是氧原子或硫原子; R4和R5各自表示氢原子; 喹诺酮骨架的3和4位之间的键是单键或双键; R1是氢原子等; R2是氢原子等; R3是氢原子等。本发明的喹诺酮化合物或其盐诱导TFF的产生，因此可用于治疗和/或预防诸如消化道疾病，口腔疾病，上呼吸道疾病 疾病，呼吸道疾病，眼睛疾病，癌症和伤口。

公开(公告)号：US08188277B2

公开(公告)日：2012-05-29

申请号：US11659689

申请日：2005-08-03

申请人： Tae Fukushima ,  Shuji Matsumura ,  Noriaki Takemura ,  Hideaki Satou ,  Nobuaki Ito ,  Takuya Shitsuta ,  Hironori Tsutsui ,  Michinori Tanaka ,  Keizo Kan ,  Hitoshi Nagao ,  Kenji Watanabe ,  Kuninori Tai ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Keisuke Miyajima ,  Satoshi Yamada ,  Yutaka Kojima ,  Koichi Yasumura ,  Naoto Ohi ,  Mitsuhiro Okuno ,  Kazuhisa Sugiyama ,  Kunihiko Kiyono ,  Takashi Suzuki ,  Seiji Akamatsu ,  Takeshi Kodama ,  Yasuo Yanagihara ,  Takumi Sumida

发明人： Tae Fukushima ,  Shuji Matsumura ,  Noriaki Takemura ,  Hideaki Satou ,  Nobuaki Ito ,  Takuya Shitsuta ,  Hironori Tsutsui ,  Michinori Tanaka ,  Keizo Kan ,  Hitoshi Nagao ,  Kenji Watanabe ,  Kuninori Tai ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Keisuke Miyajima ,  Satoshi Yamada ,  Yutaka Kojima ,  Koichi Yasumura ,  Naoto Ohi ,  Mitsuhiro Okuno ,  Kazuhisa Sugiyama ,  Kunihiko Kiyono ,  Takashi Suzuki ,  Seiji Akamatsu ,  Takeshi Kodama ,  Yasuo Yanagihara ,  Takumi Sumida

IPC分类号： C07D241/36 ,  C07D413/12 ,  C07D403/12 ,  C07D221/02 ,  C07D401/12 ,  C07D213/62 ,  A61K31/535 ,  A61K31/497 ,  A61K31/445

CPC分类号： C07C229/18 ,  C07C205/38 ,  C07C217/90 ,  C07C233/45 ,  C07C233/75 ,  C07C271/58 ,  C07C275/34 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D211/46 ,  C07D211/58 ,  C07D211/62 ,  C07D211/70 ,  C07D213/75 ,  C07D239/42 ,  C07D241/20 ,  C07D295/185 ,  C07D295/192 ,  C07D317/58 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH═; R1 represents a group —Z—R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.

摘要翻译： 本发明提供了一种新颖的化合物，其具有优异的抑制胶原产生的效果和较少的副作用。 本发明的化合物由以下通式（1）表示：[其中X 1表示氮原子或-CH =; R1表示基团-Z-R6，其中Z表示基团-CO-，基团-CH（OH） - 等，R6表示5至15元单环，双环或三环饱和或 具有1-4个氮原子的不饱和杂环基，氧原子或硫原子; R2表示氢原子，卤素原子或低级亚烷基; Y表示基团-O-，基团-CO-，基团-CH（OH） - ，低级亚烷基基团等; A表示基团等，其中R3表示氢原子，低级烷氧基等，p表示1或2，R4表示咪唑基低级烷基等。

公开(公告)号：US20070270422A1

公开(公告)日：2007-11-22

申请号：US11659689

申请日：2005-08-03

申请人： Tae Fukushima ,  Shuji Matsumura ,  Noriaki Takemura ,  Hideaki Satou ,  Nobuaki Ito ,  Takuya Shitsuta ,  Hironori Tsutsui ,  Michinori Tanaka ,  Keizo Kan ,  Hitoshi Nagao ,  Kenji Watanabe ,  Kuninori Tai ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Keisuke Miyajima ,  Satoshi Yamada ,  Yutaka Kojima ,  Koichi Yasumura ,  Naoto Ohi ,  Mitsuhiro Okuno ,  Kazuhisa Sugiyama ,  Kunihiko Kiyono ,  Takashi Suzuki ,  Seiji Akamatsu ,  Takeshi Kodama ,  Yasuo Yanagihara ,  Takumi Sumida

发明人： Tae Fukushima ,  Shuji Matsumura ,  Noriaki Takemura ,  Hideaki Satou ,  Nobuaki Ito ,  Takuya Shitsuta ,  Hironori Tsutsui ,  Michinori Tanaka ,  Keizo Kan ,  Hitoshi Nagao ,  Kenji Watanabe ,  Kuninori Tai ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Keisuke Miyajima ,  Satoshi Yamada ,  Yutaka Kojima ,  Koichi Yasumura ,  Naoto Ohi ,  Mitsuhiro Okuno ,  Kazuhisa Sugiyama ,  Kunihiko Kiyono ,  Takashi Suzuki ,  Seiji Akamatsu ,  Takeshi Kodama ,  Yasuo Yanagihara ,  Takumi Sumida

IPC分类号： C07D401/14 ,  A61K31/165 ,  A61K31/167 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5375 ,  A61K31/5377 ,  A61P11/00 ,  C07C233/00 ,  C07C233/92 ,  C07D211/00 ,  C07D211/40 ,  C07D211/56 ,  C07D241/04 ,  C07D413/14 ,  C07D413/02 ,  C07D241/36

CPC分类号： C07C229/18 ,  C07C205/38 ,  C07C217/90 ,  C07C233/45 ,  C07C233/75 ,  C07C271/58 ,  C07C275/34 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D211/46 ,  C07D211/58 ,  C07D211/62 ,  C07D211/70 ,  C07D213/75 ,  C07D239/42 ,  C07D241/20 ,  C07D295/185 ,  C07D295/192 ,  C07D317/58 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH═; R1 represents a group -Z-R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.

摘要翻译： 本发明提供了一种新颖的化合物，其具有优异的抑制胶原产生的效果和较少的副作用。 本发明的化合物由以下通式（1）表示：[其中X 1表示氮原子或基团-CH-; R 1表示基团-ZR 6，其中Z表示-CO-基团，-CH（OH） - 基等基团，R“ 6表示具有1至4个氮原子，氧原子或硫原子的5至15元单环，二环或三环饱和或不饱和杂环基; R 2表示氢原子，卤素原子或低级亚烷基; Y表示基团-O-，基团-CO-，基团-CH（OH） - ，低级亚烷基基团等; A表示基团等，其中R 3表示氢原子，低级烷氧基等，p表示1或2，R 4表示 咪唑基低级烷基等。

公开(公告)号：US20060137841A1

公开(公告)日：2006-06-29

申请号：US11290833

申请日：2005-12-01

申请人： Akinobu Chatani ,  Koji Okomori ,  Hiroshi Koyamoto ,  Hitoshi Nagao ,  Hirokazu Morii

发明人： Akinobu Chatani ,  Koji Okomori ,  Hiroshi Koyamoto ,  Hitoshi Nagao ,  Hirokazu Morii

IPC分类号： D21H19/38 ,  C08J7/04

CPC分类号： D21H19/38 ,  Y10T428/24802 ,  Y10T428/24934 ,  Y10T428/27 ,  Y10T428/273

摘要： The present invention aims to provide coated printing papers having fast ink drying properties comparable to those of conventional newsprint, without stickiness, having good printability such as sharpness of printed images comparable to those of coated papers, as well as having the effect of decomposing harmful substances by exposure to light, especially when using penetration drying type news inks. A coated printing paper is provided, comprising a coating layer containing a pigment and an adhesive on a base paper, characterized in that a fine titanium oxide powder having a photocatalytic effect is contained in the coating layer and that the coated paper has an oil absorbency of 20 g/m2 or more under pressure and a Bekk smoothness of 75 seconds or less.

摘要翻译： 本发明的目的是提供具有与传统新闻纸相当的快速油墨干燥性能的涂布印刷纸，不粘性，具有良好的可印刷性，例如与涂布纸相当的印刷图像的清晰度，以及具有分解有害物质的作用 通过曝光，特别是当使用渗透干燥型新闻油墨时。 提供一种涂布印刷纸，其包含在原纸上含有颜料和粘合剂的涂层，其特征在于，在涂层中含有具有光催化效果的细氧化钛粉末，并且涂布纸具有吸油性 压力为20g / m 2以上，Bekk平滑度为75秒以下。

公开(公告)号：US09079773B2

公开(公告)日：2015-07-14

申请号：US13145642

申请日：2009-05-28

申请人： Tomio Fujita ,  Hitoshi Nagao ,  Shiro Yamauchi

发明人： Tomio Fujita ,  Hitoshi Nagao ,  Shiro Yamauchi

IPC分类号： B01J19/08 ,  C01B13/11

CPC分类号： C01B13/11 ,  C01B2201/14 ,  C01B2201/22 ,  C01B2201/32 ,  C01B2201/64 ,  C01B2201/72

摘要： There is provided an ozone generating apparatus that requires no use of cooling water, is small in size and easy in maintenance. The ozone generating apparatus includes a ground electrode 1 formed of a substantially cylindrical metal tube, and a high voltage electrode 5 having a substantially cylindrical dielectric body substantially concentrically arranged inside the ground electrode, and having a high voltage applied to an electrically conductive layer 6 formed on an inner peripheral surface thereof, in which an oxygen-containing gas is supplied into an electric discharge gap formed between the ground electrode and the high voltage electrode to generate ozone, wherein the ground electrode is formed integrally with plural air cooling fins 2 extending in a longitudinal direction at an outer peripheral side thereof.

摘要翻译： 提供了不需要使用冷却水的臭氧发生装置，尺寸小，维护方便。 臭氧发生装置包括由大致圆筒状的金属管形成的接地电极1和具有基本上同心配置在接地电极内部的大致圆筒状的电介质体的高电压电极5，并具有施加到形成的导电层6的高电压 在其内周面上，将含氧气体供给到形成在接地电极和高电压电极之间的放电间隙，生成臭氧，其中，接地电极与多个空气冷却翅片2一体地形成， 在其外周侧的纵向方向。

公开(公告)号：US20120238750A1

公开(公告)日：2012-09-20

申请号：US13409090

申请日：2012-02-29

申请人： Tae FUKUSHIMA ,  Shuji Matsumura ,  Noriaki Takemura ,  Hideaki Satou ,  Nobuaki Ito ,  Takuya Shitsuta ,  Hironori Tsutsui ,  Michinori Tanaka ,  Keizo Kan ,  Hitoshi Nagao ,  Kenji Watanabe ,  Kuninori Tai ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Keisuke Miyajima ,  Satoshi Yamada ,  Yutaka Kojima ,  Koichi Yasumura ,  Naoto Ohi ,  Mitsuhiro Okuno ,  Kazuhisa Sugiyama ,  Kunihiko Kiyono ,  Takashi Suzuki ,  Seiji Akamatsu ,  Takeshi Kodama ,  Yasuo Yanagihara ,  Takumi Sumida

发明人： Tae FUKUSHIMA ,  Shuji Matsumura ,  Noriaki Takemura ,  Hideaki Satou ,  Nobuaki Ito ,  Takuya Shitsuta ,  Hironori Tsutsui ,  Michinori Tanaka ,  Keizo Kan ,  Hitoshi Nagao ,  Kenji Watanabe ,  Kuninori Tai ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Keisuke Miyajima ,  Satoshi Yamada ,  Yutaka Kojima ,  Koichi Yasumura ,  Naoto Ohi ,  Mitsuhiro Okuno ,  Kazuhisa Sugiyama ,  Kunihiko Kiyono ,  Takashi Suzuki ,  Seiji Akamatsu ,  Takeshi Kodama ,  Yasuo Yanagihara ,  Takumi Sumida

IPC分类号： C07D401/12 ,  C07D413/14 ,  C07D211/46 ,  C07D295/155 ,  C07D405/14

CPC分类号： C07C229/18 ,  C07C205/38 ,  C07C217/90 ,  C07C233/45 ,  C07C233/75 ,  C07C271/58 ,  C07C275/34 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D211/46 ,  C07D211/58 ,  C07D211/62 ,  C07D211/70 ,  C07D213/75 ,  C07D239/42 ,  C07D241/20 ,  C07D295/185 ,  C07D295/192 ,  C07D317/58 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH═; R1 represents a group —Z—R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.

摘要翻译： 本发明的化合物由以下通式（1）表示：[其中X 1表示氮原子或-CH =; R1表示基团-Z-R6，其中Z表示基团-CO-，基团-CH（OH） - 等，R6表示5至15元单环，双环或三环饱和或 具有1-4个氮原子的不饱和杂环基，氧原子或硫原子; R2表示氢原子，卤素原子或低级亚烷基; Y表示基团-O-，基团-CO-，基团-CH（OH） - ，低级亚烷基基团等; A表示基团等，其中R3表示氢原子，低级烷氧基等，p表示1或2，R4表示咪唑基低级烷基等。

公开(公告)号：US20100261705A1

公开(公告)日：2010-10-14

申请号：US12611921

申请日：2009-11-03

申请人： Takeshi Kuroda ,  Takahito Yamauchi ,  Tomoichi Shinohara ,  Kunio Oshima ,  Chiharu Kitajima ,  Hitoshi Nagao ,  Tae Fukushima ,  Takahiro Tomoyasu ,  Hironobu Ishiyama ,  Ohta Kazuhide ,  Masaaki Takano ,  Takumi Sumida

发明人： Takeshi Kuroda ,  Takahito Yamauchi ,  Tomoichi Shinohara ,  Kunio Oshima ,  Chiharu Kitajima ,  Hitoshi Nagao ,  Tae Fukushima ,  Takahiro Tomoyasu ,  Hironobu Ishiyama ,  Ohta Kazuhide ,  Masaaki Takano ,  Takumi Sumida

IPC分类号： A61K31/4709 ,  C07D417/10 ,  C07D417/14 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/506 ,  A61K31/473 ,  A61K31/498 ,  A61K31/55 ,  A61P1/00 ,  A61P11/00 ,  A61P27/02 ,  A61P35/00 ,  A61P17/02

CPC分类号： C07D471/08 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04

摘要： The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R4 and R5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R1 is a hydrogen atom, etc; R2 is a hydrogen atom, etc; and R3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

摘要翻译： 本发明提供由通式（1）表示的喹诺酮化合物或其盐，其中A为直接键，低级亚烷基或低级亚烷基; X是氧原子或硫原子; R4和R5各自表示氢原子; 喹诺酮骨架的3和4位之间的键是单键或双键; R1是氢原子等; R2是氢原子等; R3是氢原子等。本发明的喹诺酮化合物或其盐诱导TFF的产生，因此可用于治疗和/或预防诸如消化道疾病，口腔疾病，上呼吸道疾病 疾病，呼吸道疾病，眼睛疾病，癌症和伤口。

公开(公告)号：US07575802B2

公开(公告)日：2009-08-18

申请号：US11290833

申请日：2005-12-01

申请人： Akinobu Chatani ,  Koji Okomori ,  Hiroshi Koyamoto ,  Hitoshi Nagao ,  Hirokazu Morii

发明人： Akinobu Chatani ,  Koji Okomori ,  Hiroshi Koyamoto ,  Hitoshi Nagao ,  Hirokazu Morii

IPC分类号： C08J7/04

CPC分类号： D21H19/38 ,  Y10T428/24802 ,  Y10T428/24934 ,  Y10T428/27 ,  Y10T428/273

摘要： The present invention aims to provide coated printing papers having fast ink drying properties comparable to those of conventional newsprint, without stickiness, having good printability such as sharpness of printed images comparable to those of coated papers, as well as having the effect of decomposing harmful substances by exposure to light, especially when using penetration drying type news inks.A coated printing paper is provided, comprising a coating layer containing a pigment and an adhesive on a base paper, characterized in that a fine titanium oxide powder having a photocatalytic effect is contained in the coating layer and that the coated paper has an oil absorbency of 20 g/m2 or more under pressure and a Bekk smoothness of 75 seconds or less.

摘要翻译： 本发明的目的是提供具有与传统新闻纸相当的快速油墨干燥性能的涂布印刷纸，不粘性，具有良好的可印刷性，例如与涂布纸相当的印刷图像的清晰度，以及具有分解有害物质的作用 通过曝光，特别是当使用渗透干燥型新闻油墨时。 提供一种涂布印刷纸，其包括在原纸上含有颜料和粘合剂的涂层，其特征在于，在涂层中含有具有光催化效果的细氧化钛粉末，并且涂布纸具有吸油性 压力为20g / m 2以上，Bekk平滑度为75秒以下。

公开(公告)号：US20110280774A1

公开(公告)日：2011-11-17

申请号：US13145642

申请日：2009-05-28

申请人： Tomio Fujita ,  Hitoshi Nagao ,  Shiro Yamauchi

发明人： Tomio Fujita ,  Hitoshi Nagao ,  Shiro Yamauchi

IPC分类号： B01J19/08

CPC分类号： C01B13/11 ,  C01B2201/14 ,  C01B2201/22 ,  C01B2201/32 ,  C01B2201/64 ,  C01B2201/72

摘要： There is provided an ozone generating apparatus that requires no use of cooling water, is small in size and easy in maintenance. The ozone generating apparatus includes a ground electrode 1 formed of a substantially cylindrical metal tube, and a high voltage electrode 5 having a substantially cylindrical dielectric body substantially concentrically arranged inside the ground electrode, and having a high voltage applied to an electrically conductive layer 6 formed on an inner peripheral surface thereof, in which an oxygen-containing gas is supplied into an electric discharge gap formed between the ground electrode and the high voltage electrode to generate ozone, wherein the ground electrode is formed integrally with plural air cooling fins 2 extending in a longitudinal direction at an outer peripheral side thereof.

摘要翻译： 提供了不需要使用冷却水的臭氧发生装置，尺寸小，维护方便。 臭氧发生装置包括由大致圆筒状的金属管形成的接地电极1和具有基本上同心配置在接地电极内部的大致圆筒状的电介质体的高电压电极5，并具有施加到形成的导电层6的高电压 在其内周面上，将含氧气体供给到形成在接地电极和高电压电极之间的放电间隙，生成臭氧，其中，接地电极与多个空气冷却翅片2一体地形成， 在其外周侧的纵向方向。

公开(公告)号：US07777038B2

公开(公告)日：2010-08-17

申请号：US10582014

申请日：2005-09-26

申请人： Takeshi Kuroda ,  Takahito Yamauchi ,  Tomoichi Shinohara ,  Kunio Oshima ,  Chiharu Kitajima ,  Hitoshi Nagao ,  Tae Fukushima ,  Takahiro Tomoyasu ,  Hironobu Ishiyama ,  Kazuhide Ohta ,  Masaaki Takano ,  Takumi Sumida

发明人： Takeshi Kuroda ,  Takahito Yamauchi ,  Tomoichi Shinohara ,  Kunio Oshima ,  Chiharu Kitajima ,  Hitoshi Nagao ,  Tae Fukushima ,  Takahiro Tomoyasu ,  Hironobu Ishiyama ,  Kazuhide Ohta ,  Masaaki Takano ,  Takumi Sumida

IPC分类号： C07D215/38

CPC分类号： C07D471/08 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04

摘要： The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R4 and R5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R1 is a hydrogen atom, etc; R2 is a hydrogen atom, etc; and R3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

摘要翻译： 本发明提供由通式（1）表示的喹诺酮化合物或其盐，其中A为直接键，低级亚烷基或低级亚烷基; X是氧原子或硫原子; R4和R5各自表示氢原子; 喹诺酮骨架的3和4位之间的键是单键或双键; R1是氢原子等; R2是氢原子等; R3是氢原子等。本发明的喹诺酮化合物或其盐诱导TFF的产生，因此可用于治疗和/或预防诸如消化道疾病，口腔疾病，上呼吸道疾病 疾病，呼吸道疾病，眼睛疾病，癌症和伤口。