Invention Grant
- Patent Title: Identification of a family of secreted proteins in vascular endothelium
- Patent Title (中): 鉴定血管内皮分泌蛋白家族
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Application No.: US12317046Application Date: 2008-12-18
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Publication No.: US08211640B2Publication Date: 2012-07-03
- Inventor: Ruey-Bing Yang , Chi Kin Domingos Ng , James E. Tomlinson , Laszlo G. Komuves , James N. Topper , Keith E. Robison
- Applicant: Ruey-Bing Yang , Chi Kin Domingos Ng , James E. Tomlinson , Laszlo G. Komuves , James N. Topper , Keith E. Robison
- Applicant Address: US MA Cambridge
- Assignee: Millennium Pharmaceuticals, Inc.
- Current Assignee: Millennium Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Millennium Pharmaceuticals, Inc.
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12Q1/02 ; C12P21/06 ; C12N5/00 ; C12N5/02 ; C12N1/20 ; C12N15/12
Abstract:
The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.
Public/Granted literature
- US20090264361A1 Identification of a family of secreted proteins in vascular endothelium Public/Granted day:2009-10-22
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