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1.发明申请Novel 15571, 2465, 14266, 2882, 52871, 8203 and 16852 molecules and uses therefor 审中-公开小分子15571,2245,14266,2882,52871,8203和16852分子及其用途公开(公告)号：US20090226450A1
公开(公告)日：2009-09-10
申请号：US12386856
申请日：2009-04-23
Applicant: Martin R. Hodge , Clare M. Lloyd , Nadine S. Weich , Jose M. Lora , David White , Maria A. Glucksmann , Keith E. Robison , Inmaculada Silos-Santiago , Andrew D.J. Goodearl , Rory A.J. Curtis
Inventor： Martin R. Hodge , Clare M. Lloyd , Nadine S. Weich , Jose M. Lora , David White , Maria A. Glucksmann , Keith E. Robison , Inmaculada Silos-Santiago , Andrew D.J. Goodearl , Rory A.J. Curtis
IPC: A61K39/395 , C12N15/11 , C12N5/00 , C07K14/00 , C07K16/18 , C12P21/02 , G01N33/566 , G01N33/53 , C12Q1/68 , A61K38/02 , A61K38/16 , A61K31/7088
CPC classification number: C07K14/47 , C07K16/286 , G01N33/6893 , G01N33/74 , G01N2333/726 , G01N2500/04 , G01N2800/122 , G01N2800/24
Abstract: The invention provides isolated nucleic acids molecules, designated 15571, 2465, 14266, 2882, 52871, 8203 or 16852 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 15571, 2465, 14266, 2882, 52871, 8203 or 16852 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 15571, 2465, 14266, 2882, 52871, 8203 or 16852 gene has been introduced or disrupted. The invention still further provides isolated 15571, 2465, 14266, 2882, 52871, 8203 or 16852 proteins, fusion proteins, antigenic peptides and anti-15571, 2465, 14266, 2882, 52871, 8203 or 16852 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
Abstract translation: 本发明提供分离的核酸分子，命名为15571,2465,14266,2882,52871,8203或16852核酸分子。 本发明还提供反义核酸分子，含有15571,2465,14266,2882,52871,8203或16852核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中15571， 2465,14266,2882,52871,8203或16852基因已被引入或破坏。 本发明还进一步提供了分离的15571,2465,14266,2882,52871,8203或16852蛋白，融合蛋白，抗原肽和抗15571,2465,14266,2882,52871,8203或16852抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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2.发明申请NOVEL 15571, 2465, 14266, 2882, 52871, 8203 AND 16852 MOLECULES AND USES THEREFOR 审中-公开新型15571,2245,14266,2882,52871,8203和16852分子及其用途公开(公告)号：US20110171205A1
公开(公告)日：2011-07-14
申请号：US13012890
申请日：2011-01-25
Applicant: Martin R. Hodge , Clare M. Lloyd , Nadine S. Weich , Jose M. Lora , David White , Maria A. Glucksmann , Keith E. Robison , Inmaculada Silos-Santiago , Andrew D.J. Goodearl , Rory A.J. Curtis
Inventor： Martin R. Hodge , Clare M. Lloyd , Nadine S. Weich , Jose M. Lora , David White , Maria A. Glucksmann , Keith E. Robison , Inmaculada Silos-Santiago , Andrew D.J. Goodearl , Rory A.J. Curtis
IPC: A61K39/395 , C07H21/04 , C12N5/00 , C07K14/00 , C07K16/18 , C12P21/02 , C12Q1/68 , G01N33/53 , A61K38/17 , A61K31/7088 , C12N15/11 , C12N1/21 , A61P25/00 , A61P19/02 , A61P25/28 , A61P25/16 , A61P25/18 , A61P9/00 , A61P9/04 , A61P35/00 , A61P3/10 , A61P15/02
CPC classification number: C07K14/47 , C07K16/286 , G01N33/6893 , G01N33/74 , G01N2333/726 , G01N2500/04 , G01N2800/122 , G01N2800/24
Abstract: The invention provides isolated nucleic acids molecules, designated 15571, 2465, 14266, 2882, 52871, 8203 or 16852 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 15571, 2465, 14266, 2882, 52871, 8203 or 16852 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 15571, 2465, 14266, 2882, 52871, 8203 or 16852 gene has been introduced or disrupted. The invention still further provides isolated 15571, 2465, 14266, 2882, 52871, 8203 or 16852 proteins, fusion proteins, antigenic peptides and anti-15571, 2465, 14266, 2882, 52871, 8203 or 16852 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
Abstract translation: 本发明提供分离的核酸分子，命名为15571,2465,14266,2882,52871,8203或16852核酸分子。 本发明还提供反义核酸分子，含有15571,2465,14266,2882,52871,8203或16852核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中15571， 2465,14266,2882,52871,8203或16852基因已被引入或破坏。 本发明还进一步提供了分离的15571,2465,14266,2882,52871,8203或16852蛋白，融合蛋白，抗原肽和抗15571,2465,14266,2882,52871,8203或16852抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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公开(公告)号：US20090264361A1
公开(公告)日：2009-10-22
申请号：US12317046
申请日：2008-12-18
Applicant: Ruey-Bing Yang , Chi Kin Domingos Ng , James E. Tomlinson , Laszlo G. Komuves , James N. Topper , Keith E. Robison
Inventor： Ruey-Bing Yang , Chi Kin Domingos Ng , James E. Tomlinson , Laszlo G. Komuves , James N. Topper , Keith E. Robison
IPC: A61K38/16 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/02 , C07K14/00 , C07K16/00 , C12Q1/68 , G01N33/53 , A61P9/10 , A61P7/00 , A61P13/00
CPC classification number: C07K14/47 , G01N2333/485
Abstract: The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.
Abstract translation: 本发明涉及SCUBE分子，通常涉及血管内皮细胞中的基因表达。 本发明具体涉及含有本文所述的可在内皮细胞中表达的SCUBE1，SCUBE2和SCUBE3的基因和蛋白质的新基因家族的发现。 SCUBE蛋白可能参与心血管疾病，止血，血栓形成，炎性疾病，骨代谢障碍，膀胱疾病和乳腺疾病的发展。
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公开(公告)号：US07258988B2
公开(公告)日：2007-08-21
申请号：US10406073
申请日：2003-04-03
Applicant: Ruey-Bing Yang , Chi Kin Domingos Ng , James E. Tomlinson , Laszlo G. Komuves , James N. Topper , Keith E. Robison
Inventor： Ruey-Bing Yang , Chi Kin Domingos Ng , James E. Tomlinson , Laszlo G. Komuves , James N. Topper , Keith E. Robison
IPC: G01N33/53 , C07K14/435 , C07K16/30
CPC classification number: C07K14/47 , G01N2333/485
Abstract: The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.
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5.发明授权Nucleic acid molecules encoding human kinase and phosphatase homologues and uses therefor 失效编码人类激酶和磷酸酶同系物的核酸分子及其用途公开(公告)号：US06500628B1
公开(公告)日：2002-12-31
申请号：US09579182
申请日：2000-05-25
Applicant: Keith E. Robison
Inventor： Keith E. Robison
IPC: C12Q148
CPC classification number: C12N9/1205 , C12N9/16 , G01N33/573
Abstract: The invention provides isolated nucleic acids molecules, designated Kinase and Phosphatase nucleic acid molecules, which encode novel protein kinase and protein Phosphatase polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing Kinase and Phosphatase nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a Kinase and Phosphatase gene has been introduced or disrupted. The invention still further provides isolated Kinase and Phosphatase proteins, fusion proteins, antigenic peptides and anti-Kinase and Phosphatase antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
Abstract translation: 本发明提供分离的核酸分子，命名为激酶和磷酸酶核酸分子，其编码新的蛋白激酶和蛋白质磷酸酶多肽。 本发明还提供反义核酸分子，含有激酶和磷酸酶核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中引入或破坏了激酶和磷酸酶基因的非人类转基因动物。 本发明还进一步提供了分离的激酶和磷酸酶蛋白，融合蛋白，抗原肽和抗激酶和磷酸酶抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。
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Patent Agency Ranking
6.发明授权Nucleic acid molecules encoding human kinase and phosphatase homologues and uses therefor 失效编码人类激酶和磷酸酶同系物的核酸分子及其用途公开(公告)号：US06309849B1
公开(公告)日：2001-10-30
申请号：US09387212
申请日：1999-08-31
Applicant: Keith E. Robison
Inventor： Keith E. Robison
IPC: C12Q148
CPC classification number: G01N33/573 , A61K38/00 , C07K2319/00 , C12N9/12 , C12N9/16 , G01N2333/9121 , G01N2500/00
Abstract: The invention provides isolated nucleic acids molecules, designated Kinase and Phosphatase nucleic acid molecules, which encode novel protein kinase and protein phosphatase polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing Kinase and Phosphatase nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a Kinase and Phosphatase gene has been introduced or disrupted. The invention still further provides isolated Kinase and Phosphatase proteins, fusion proteins, antigenic peptides and anti-Kinase and Phosphatase antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
Abstract translation: 本发明提供编码新的蛋白激酶和蛋白磷酸酶多肽的分离的核酸分子，命名为激酶和磷酸酶核酸分子。 本发明还提供反义核酸分子，含有激酶和磷酸酶核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中引入或破坏了激酶和磷酸酶基因的非人类转基因动物。 本发明还进一步提供了分离的激酶和磷酸酶蛋白，融合蛋白，抗原肽和抗激酶和磷酸酶抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US20100273989A1
公开(公告)日：2010-10-28
申请号：US12340815
申请日：2008-12-22
Applicant: Susan Acton , Keith E. Robison , Frank Y. Hsieh
Inventor： Susan Acton , Keith E. Robison , Frank Y. Hsieh
IPC: C07K16/18
CPC classification number: A61K38/4813 , C12N9/48 , C12Y304/15001
Abstract: The present invention relates to the discovery of novel genes encoding an angiotensin converting enzyme, Angiotensin Converting Enzyme-2 (ACE-2). The invention provides therapeutics, prognostic and diagnostic methods for treating blood pressure related disorders as well as various types of allergic conditions, among others. Also disclosed are screening assays for identifying compounds for treating and preventing these conditions.
Abstract translation: 本发明涉及编码血管紧张素转换酶血管紧张素转化酶-2（ACE-2）的新基因的发现。 本发明提供了用于治疗血压相关疾病以及各种类型的变态反应病症的治疗，预后和诊断方法。 还公开了用于鉴定用于治疗和预防这些病症的化合物的筛选测定。
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8.发明申请Novel 27875, 22025, 27420, 17906, 16319, 55092 and 10218 molecules and uses therefor 审中-公开小分子27875,22025,27420,17906,16319,55092和10218分子及其用途公开(公告)号：US20100136010A1
公开(公告)日：2010-06-03
申请号：US12288465
申请日：2008-10-21
Applicant: Rosana Kappeller-Libermann , David White , Keith E. Robison , Kyle J. MacBeth , Joseph M. Carroll , William James Cook , Rachel E. Meyers , Miyoung Chun , Mark J. Williamson
Inventor： Rosana Kappeller-Libermann , David White , Keith E. Robison , Kyle J. MacBeth , Joseph M. Carroll , William James Cook , Rachel E. Meyers , Miyoung Chun , Mark J. Williamson
IPC: A61K39/395 , A61K38/45 , A61K38/46 , A61K38/48 , C12Q1/68 , G01N33/53 , C12Q1/34 , C12P21/00 , C12N5/10 , C12N5/00 , A61K38/00 , A61K38/17 , A61K31/713 , A61K31/7088 , C07K14/435 , C07K16/40 , C07H21/04 , A61P31/12 , A61P9/00 , A61P35/00 , A61P19/08 , A61P7/00
CPC classification number: G01N33/5008 , A61K38/00 , C12N9/1007 , C12N9/16 , C12N9/6489 , C12Q1/37 , C12Q1/6883 , C12Q2600/158 , C12Y301/04017 , G01N33/5011 , G01N33/502 , G01N33/56983 , G01N33/56994 , G01N33/57426 , G01N33/5761 , G01N33/5767 , G01N33/68 , G01N2333/916 , G01N2333/96486 , G01N2500/04
Abstract: The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
Abstract translation: 本发明提供分离的核酸分子，命名为27875,22025,27420,16319,55092和10218核酸分子。 本发明还提供反义核酸分子，含有27875,22025,27420,16319,55092和10218核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中27875,22025， 27420,16319,55092和10218基因已被引入或破坏。 本发明还进一步提供了分离的27875,22025,27420,17906,16319,55092或10218蛋白，融合蛋白，抗原肽和抗27875,22025,27420,17906,16319,55092或10218抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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公开(公告)号：US06395889B1
公开(公告)日：2002-05-28
申请号：US09392184
申请日：1999-09-09
Applicant: Keith E. Robison
Inventor： Keith E. Robison
IPC: C12N1557
CPC classification number: C12N9/64
Abstract: The invention relates to polynucleotides encoding newly identified protease homologs. The invention also relates to the proteases. The invention further relates to methods using the protease polypeptides and polynucleotides as a target for diagnosis and treatment in protease-mediated disorders. The invention further relates to drug-screening methods using the protease polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the protease polypeptides and polynucleotides. The invention further relates to procedures for producing the protease polypeptides and polynucleotides.
Abstract translation: 本发明涉及编码新鉴定的蛋白酶同系物的多核苷酸。 本发明还涉及蛋白酶。 本发明还涉及使用蛋白酶多肽和多核苷酸作为在蛋白酶介导的病症中进行诊断和治疗的靶标的方法。 本发明还涉及使用蛋白酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于蛋白酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及产生蛋白酶多肽和多核苷酸的方法。
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公开(公告)号：US07482171B2
公开(公告)日：2009-01-27
申请号：US11059218
申请日：2005-02-16
Applicant: Susan Acton , Keith E. Robison , Frank Y. Hsieh
Inventor： Susan Acton , Keith E. Robison , Frank Y. Hsieh
IPC: G01N33/566
CPC classification number: A61K38/4813 , C12N9/48 , C12Y304/15001
Abstract: The present invention relates to the discovery of novel genes encoding an angiotensin converting enzyme, Angiotensin Converting Enzyme-2 (ACE-2). The invention provides therapeutics, prognostic and diagnostics methods for treating blood pressure related disorders as well as various types of allergic conditions, among others. Also disclosed are screening assays for identifying compounds for treating and preventing these conditions.
Abstract translation: 本发明涉及编码血管紧张素转换酶血管紧张素转化酶-2（ACE-2）的新基因的发现。 本发明提供了用于治疗血压相关疾病以及各种类型的变态反应病症的治疗，预后和诊断方法。 还公开了用于鉴定用于治疗和预防这些病症的化合物的筛选测定。
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