发明授权
- 专利标题: Biological bypass bridge with sodium channels, calcium channels and/or potassium channels to compensate for conduction block in the heart
- 专利标题(中): 具有钠通道,钙通道和/或钾通道的生物旁路桥以补偿心脏中的传导阻滞
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申请号: US11490760申请日: 2006-07-21
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公开(公告)号: US08236296B2公开(公告)日: 2012-08-07
- 发明人: Michael R Rosen , Peter R. Brink , Ira S. Cohen , Richard B Robinson , Peter Danilo, Jr.
- 申请人: Michael R Rosen , Peter R. Brink , Ira S. Cohen , Richard B Robinson , Peter Danilo, Jr.
- 申请人地址: US NY New York US NY Albany
- 专利权人: The Trustees of Columbia University in the City of New York,The Research Foundation of State University of New York
- 当前专利权人: The Trustees of Columbia University in the City of New York,The Research Foundation of State University of New York
- 当前专利权人地址: US NY New York US NY Albany
- 代理机构: Evans & Molinelli PLLC
- 代理商 Judith Evans
- 主分类号: A01N63/00
- IPC分类号: A01N63/00 ; A61K48/00 ; C12N15/63 ; C07H21/04
摘要:
This invention provides a bypass bridge comprising a tract of gap junction-coupled cells having a first end and a second end, both ends capable of being attached to two selected sites in a heart so as to allow the conduction of a pacemaker and/or electrical signal/current across the tract between the two sites, wherein the cells functionally express a sodium channel. The invention also provides related methods of making the bypass bridge, methods of implanting same in a heart, and methods of treating a disorder associated with an impaired conduction in a subject's heart.