Invention Grant
US08299218B2 Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
有权
中和肉毒杆菌神经毒素的治疗性单克隆抗体
- Patent Title: Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
- Patent Title (中): 中和肉毒杆菌神经毒素的治疗性单克隆抗体
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Application No.: US12468526Application Date: 2009-05-19
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Publication No.: US08299218B2Publication Date: 2012-10-30
- Inventor: James D. Marks , Ali Razai
- Applicant: James D. Marks , Ali Razai
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Bozicevic, Field & Francis LLP
- Agent Carol L. Francis
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C12P21/08 ; G01N33/53
Abstract:
This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
Public/Granted literature
- US20090324606A1 THERAPEUTIC MONOCLONAL ANTIBODIES THAT NEUTRALIZE BOTULINUM NEUROTOXINS Public/Granted day:2009-12-31
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