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公开(公告)号：US08263747B2
公开(公告)日：2012-09-11
申请号：US12353237
申请日：2009-01-13
Applicant: James D. Marks , Peter Amersdorfer , Ali Razai
Inventor： James D. Marks , Peter Amersdorfer , Ali Razai
IPC: A61K38/00 , A61K38/16 , A61K39/395 , A61K39/40 , A61K39/42 , A01N37/18 , C07K16/00 , C12P21/08 , G01N33/00
CPC classification number: C07K16/1282 , A61K2039/505 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/622
Abstract: This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
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2.发明申请公开(公告)号：US20080124328A1
公开(公告)日：2008-05-29
申请号：US11342271
申请日：2006-01-26
Applicant: James D. Marks , Peter Amersdorfer , Isin Geren , Jianlong Lou , Ali Razai , Maria Consuelos Garcia
Inventor： James D. Marks , Peter Amersdorfer , Isin Geren , Jianlong Lou , Ali Razai , Maria Consuelos Garcia
CPC classification number: C07K16/1282 , A61K2039/507 , C07K2317/21 , C07K2317/622 , C07K2317/76 , C07K2317/92
Abstract: This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
Abstract translation: 本发明提供了特异性结合并中和A型（BoNT / A）肉毒杆菌神经毒素和由这些抗体结合的表位的抗体。 特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。
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3.发明申请公开(公告)号：US20100166773A1
公开(公告)日：2010-07-01
申请号：US12528601
申请日：2008-03-21
Applicant: James D. Marks , Isin N. Geren , Maria Consuelo Garcia , Jianlong Lou , Ali Razai
Inventor： James D. Marks , Isin N. Geren , Maria Consuelo Garcia , Jianlong Lou , Ali Razai
CPC classification number: C07K16/40 , C07K16/1282 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
Abstract: This invention provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
Abstract translation: 本发明提供了特异性结合并典型地中和肉毒杆菌神经毒素（例如BoNT / A，BoNT / B，BoNT / E等）和由这些抗体结合的表位的抗体。 特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。
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公开(公告)号：US20090324606A1
公开(公告)日：2009-12-31
申请号：US12468526
申请日：2009-05-19
Applicant: James D. Marks , Peter Amersdorfer , Isin Nergiz Geren , Ali Razai
Inventor： James D. Marks , Peter Amersdorfer , Isin Nergiz Geren , Ali Razai
IPC: A61K39/395 , C07K16/12
CPC classification number: C07K16/1282 , A61K2039/505 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/622
Abstract: This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
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5.发明申请公开(公告)号：US20110171235A1
公开(公告)日：2011-07-14
申请号：US12646705
申请日：2009-12-23
Applicant: James D. Marks , Peter Amersdorfer , Isin Geren , Jianlong Lou , Ali Razai , Maria Consuelo Garcia
Inventor： James D. Marks , Peter Amersdorfer , Isin Geren , Jianlong Lou , Ali Razai , Maria Consuelo Garcia
CPC classification number: C07K16/1282 , A61K2039/507 , C07K2317/21 , C07K2317/622 , C07K2317/76 , C07K2317/92
Abstract: This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
Abstract translation: 本发明提供了特异性结合并中和A型（BoNT / A）肉毒杆菌神经毒素和由这些抗体结合的表位的抗体。 特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。
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Patent Agency Ranking
6.发明授权公开(公告)号：US08299218B2
公开(公告)日：2012-10-30
申请号：US12468526
申请日：2009-05-19
Applicant: James D. Marks , Ali Razai
Inventor： James D. Marks , Ali Razai
CPC classification number: C07K16/1282 , A61K2039/505 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/622
Abstract: This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
Abstract translation: 本发明提供了特异性结合并中和A型（BoNT / A）肉毒杆菌神经毒素和由这些抗体结合的表位的抗体。 特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。
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7.发明申请公开(公告)号：US20120177663A1
公开(公告)日：2012-07-12
申请号：US13175628
申请日：2011-07-01
Applicant: James D. Marks , Peter Amersdorfer , Isin Geren , Jianlong Lou , Ali Razai , Maria Consuelo Garcia
Inventor： James D. Marks , Peter Amersdorfer , Isin Geren , Jianlong Lou , Ali Razai , Maria Consuelo Garcia
IPC: A61K39/395 , A61P31/04 , G01N33/569 , C07K16/12
CPC classification number: C07K16/1282 , A61K2039/507 , C07K2317/21 , C07K2317/622 , C07K2317/76 , C07K2317/92
Abstract: This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
Abstract translation: 本发明提供了特异性结合并中和A型（BoNT / A）肉毒杆菌神经毒素和由这些抗体结合的表位的抗体。 特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。
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8.发明授权公开(公告)号：US07999079B2
公开(公告)日：2011-08-16
申请号：US12646705
申请日：2009-12-23
Applicant: James D. Marks , Peter Amersdorfer , Isin Geren , Jianlong Lou , Ali Razai , Maria Consuelo Garcia
Inventor： James D. Marks , Peter Amersdorfer , Isin Geren , Jianlong Lou , Ali Razai , Maria Consuelo Garcia
IPC: C07K16/00 , A61K39/395
CPC classification number: C07K16/1282 , A61K2039/507 , C07K2317/21 , C07K2317/622 , C07K2317/76 , C07K2317/92
Abstract: This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
Abstract translation: 本发明提供了特异性结合并中和A型（BoNT / A）肉毒杆菌神经毒素和由这些抗体结合的表位的抗体。 特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。
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9.发明授权公开(公告)号：US09145462B2
公开(公告)日：2015-09-29
申请号：US13172759
申请日：2011-06-29
Applicant: Bin Liu , James D. Marks , Xiaodong Zhu , Scott Bidlingmaier
Inventor： Bin Liu , James D. Marks , Xiaodong Zhu , Scott Bidlingmaier
IPC: A61K39/395 , C07K16/28 , C07K16/30 , C12N5/095 , G01N33/574
CPC classification number: C07K16/18 , A61K47/6843 , A61K51/1045 , C07K16/2896 , C07K16/3053 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/77 , C07K2317/92 , C12N5/0695 , G01N33/57407
Abstract: The present disclosure is generally related to antibodies that bind specifically to glioblastoma multiforme (GBM) cells. In particular, the present disclosure provides compositions comprising human single chain or full-length antibodies that bind tumor cells. Additionally the present disclosure provides methods of using the anti-GBM antibodies.
Abstract translation: 本公开通常涉及特异性结合多形性胶质母细胞瘤（GBM）细胞的抗体。 特别地，本公开提供了包含结合肿瘤细胞的人单链或全长抗体的组合物。 另外，本公开提供了使用抗GBM抗体的方法。
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公开(公告)号：US20150030600A1
公开(公告)日：2015-01-29
申请号：US13813623
申请日：2011-08-31
Applicant: James D. Marks , Yongfeng Fan , Jianlong Lou , Maria Consuelo Garcia Rodriguez , Shude Yan , Isin Nergiz Geren , Wenwu Zhai , Subhendu Chakraborti
Inventor： James D. Marks , Yongfeng Fan , Jianlong Lou , Maria Consuelo Garcia Rodriguez , Shude Yan , Isin Nergiz Geren , Wenwu Zhai , Subhendu Chakraborti
IPC: C07K16/12 , G01N33/569 , G01N33/573
CPC classification number: C07K16/40 , A61K2039/505 , A61K2039/507 , C07K16/1282 , C07K2317/20 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , G01N33/56911 , G01N33/573 , G01N2333/33 , G01N2333/952
Abstract: The present disclosure provides antibodies that specifically bind to botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
Abstract translation: 本公开提供了特异性结合肉毒杆菌神经毒素（例如BoNT / A，BoNT / B，BoNT / C，BoNT / D，BoNT / E，BoNT / F，BoNT / G等）的抗体， 那些抗体。 特异性结合本文提供的中和表位的抗体及其衍生物可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。
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