Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
    6.
    发明授权
    Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins 有权
    中和肉毒杆菌神经毒素的治疗性单克隆抗体

    公开(公告)号:US08299218B2

    公开(公告)日:2012-10-30

    申请号:US12468526

    申请日:2009-05-19

    Abstract: This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

    Abstract translation: 本发明提供了特异性结合并中和A型(BoNT / A)肉毒杆菌神经毒素和由这些抗体结合的表位的抗体。 特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素,因此也可用于治疗肉毒中毒。

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