发明授权
- 专利标题： Pharmaceutical composition which improves in vivo gene transfer
- 专利标题（中）： 改善体内基因转移的药物组合物
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申请号： US12659618申请日： 2010-03-15
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公开(公告)号： US08367631B2公开(公告)日： 2013-02-05
- 发明人: Bruno Pitard
- 申请人： Bruno Pitard
- 申请人地址： FR Paris
- 专利权人： Institut National de la Sante et de la Recherche Medicale
- 当前专利权人： Institut National de la Sante et de la Recherche Medicale
- 当前专利权人地址： FR Paris
- 代理机构： Oliff & Berridge, PLC
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A01N63/00 ; A01N65/00 ; C12N5/00 ; C12N5/02 ; C07H21/02 ; C07H21/04
摘要：
A pharmaceutical composition, including at least one nucleic acid, a Tyrode's medium having 140 mM NaC1, 6 mM KC1, 3 mM CaC12, 2 mM MgC12, 10 mM Hepes, pH 7.4, and 10 mM glucose; and a tetrafunctional copolymer of formula (I): where x and y represent, independently of one another, an integer of between 1 and 500, the tetrafunctional copolymer is in a form of a mineral salt wherein said tetrafunctional copolymer is in a cationic form. The compound of formula (I) has a molecular weight of between 1,000 and 25,000 g/mol and an EO/PO ratio of 0.8 to 1.2.
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