发明授权
- 专利标题： Method to block the infection by flaviviruses, molecules and uses
- 专利标题（中）： 阻止黄病毒，分子和用途感染的方法
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申请号： US12298808申请日： 2007-04-26
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公开(公告)号： US08420311B2公开(公告)日： 2013-04-16
- 发明人: Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martin Dunn , Monica Sarria Nunez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sanchez Puente , Vladimir Armando Besada Perez , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramon Padron Palomares , Luis Javier Gonzalez Lopez
- 申请人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martin Dunn , Monica Sarria Nunez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sanchez Puente , Vladimir Armando Besada Perez , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramon Padron Palomares , Luis Javier Gonzalez Lopez
- 申请人地址： CU Ciudad de La Habana
- 专利权人： Centro de Ingenieria Genetica y Biotecnologia
- 当前专利权人： Centro de Ingenieria Genetica y Biotecnologia
- 当前专利权人地址： CU Ciudad de La Habana
- 代理机构： Hoffmann & Baron, LLP
- 优先权： CU2006-0091 20060428
- 国际申请： PCT/CU2007/000014 WO 20070426
- 国际公布： WO2007/124698 WO 20071108
- 主分类号： C12Q1/70
- IPC分类号： C12Q1/70 ; A61K39/12
摘要：
The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
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