-
公开(公告)号：US20140206621A1
公开(公告)日：2014-07-24
申请号：US14075276
申请日：2013-11-08
申请人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
发明人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
CPC分类号： C12N15/11 , A61K31/505 , A61K31/513 , A61K33/24 , A61K38/10 , A61K38/1767 , A61K45/06 , A61K48/00 , C07K7/08 , G01N33/574 , A61K2300/00
摘要： This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.
摘要翻译： 本发明描述了通过增加与降低或阻断癌细胞增殖相关的COMMD1蛋白的核定位来治疗癌症的方法。 本发明还涉及在制造用于癌症治疗的药物中增加COMMD1蛋白的核定位的试剂的用途。 这些试剂可以是其他化合物中的肽或蛋白质。 本发明还涉及来自序列HARIKPTFRRLKWKKYKGKFW的肽的优化，以增加蛋白质COMMD的核定位，从而提高该肽的抗肿瘤效果。
-
2.发明授权公开(公告)号：US08691234B2
公开(公告)日：2014-04-08
申请号：US12430534
申请日：2009-04-27
申请人： Santiago Duenas Carrera , Juan Morales Grillo , Liz Alvarez-Lajonchere Ponce de Leon , Alexis Musacchio Lasa , Rolando Pajon Feyt , Ariel Vina Rodriguez , Julio C. Alvarez Obregon , Nelson Acosta Rivero , Gillian Martinez Donato
发明人： Santiago Duenas Carrera , Juan Morales Grillo , Liz Alvarez-Lajonchere Ponce de Leon , Alexis Musacchio Lasa , Rolando Pajon Feyt , Ariel Vina Rodriguez , Julio C. Alvarez Obregon , Nelson Acosta Rivero , Gillian Martinez Donato
IPC分类号： A61K39/00
CPC分类号： A61K39/29 , A61K39/12 , A61K39/292 , A61K2039/53 , A61K2039/55505 , A61K2039/70 , C12N2730/10134 , C12N2770/24234
摘要： Formulation of vaccine antigens, containing as main components: a—) one or several DNA expressing one or several proteins in the immunized individuals and b—) a viral antigen, in appropriate proportions. Development of new formulations, minimizing the number of components that enhance and diversify the spectrum of immune response against different pathogenic entities and generating combined vaccines against pathogens.These formulations can be applied in the pharmaceutical industry for preventive and-or therapeutic use in human.
摘要翻译： 包含作为主要成分的疫苗抗原的制剂：a-）在免疫个体中表达一种或几种蛋白质的一种或几种DNA，和b-以适当比例的病毒抗原。 开发新的配方，最大限度地减少增加和多样化针对不同病原体的免疫反应谱的组分数量，并产生抗病原体的联合疫苗。 这些制剂可以应用于制药工业中用于预防和/或治疗人类。
-
3.发明申请Peptidic Growth Hormone Secretagogues Analog Compounds and Preparations Thereof 有权肽生长激素促分泌素类似物及其制备方法公开(公告)号：US20100055118A1
公开(公告)日：2010-03-04
申请号：US12281085
申请日：2007-02-28
申请人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia Del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
发明人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia Del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
摘要： Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
摘要翻译： 通过在硅分子模拟中获得的肽化学化合物，其具有使得它们能够执行肽生长激素促分泌素相同功能的结构。 本发明还包括含有这些化合物的制剂以及在药物，食品添加剂，营养补充剂或人或动物使用的其它制剂中的用途。
-
公开(公告)号：US20090215730A1
公开(公告)日：2009-08-27
申请号：US11920031
申请日：2006-05-05
申请人： Rolando Eduardo Rodriguez Fernandez , Roberto Vera Alvarez , Ania De La Nuez Veulens , Yuliet Mazola Reyes , Silvio Ernesto Perea Rodriguez , Boris Ernesto Acevedo Castro , Alexis Musacchio Lasa , Raimundo Ubieta Gomez
发明人： Rolando Eduardo Rodriguez Fernandez , Roberto Vera Alvarez , Ania De La Nuez Veulens , Yuliet Mazola Reyes , Silvio Ernesto Perea Rodriguez , Boris Ernesto Acevedo Castro , Alexis Musacchio Lasa , Raimundo Ubieta Gomez
IPC分类号： A61K31/17 , A61K31/66 , A61K31/53 , A61K31/505 , A61K31/47 , A61K31/415 , A61K31/40 , A61K31/34 , A61K31/27 , A61K31/16 , A61K31/175 , A61K31/13 , C07D251/02 , C07D473/00 , C07D239/02 , C07D215/38 , C07D235/00 , C07D233/96 , C07D209/14 , C07D307/02 , C07C229/00 , C07F9/02 , C07C281/02 , C07C273/02 , C07C303/00 , C07C241/00
CPC分类号： C07C211/14 , C07C237/06 , C07C237/22 , C07C243/28 , C07C255/42 , C07C257/14 , C07C271/22 , C07C271/64 , C07C275/08 , C07C275/16 , C07C275/24 , C07C281/12 , C07C317/28 , C07C327/42 , C07C337/08 , C07D207/34 , C07D209/14 , C07D213/81 , C07D213/82 , C07D215/46 , C07D233/88 , C07D233/91 , C07D235/14 , C07D239/36 , C07D239/46 , C07D239/54 , C07D251/22 , C07D307/52 , C07D487/04 , C07F9/224
摘要： Chemical compounds derived by in silico molecular modelling, having a well defined structure suitable for the blocking of the phosphorylation event, through the specific interaction of the chemical with the Casein Kinase 2 enzyme substrate phosphorylation domain or it's neighbourhood. This invention comprises also the pharmaceutical compositions containing such compounds, and their use in the preparation of medicines or agents for the treatment of diseases or conditions related with neoplasic processes.
摘要翻译： 通过在硅分子模拟中得到的化学化合物通过化学物质与酪蛋白激酶2酶底物磷酸化结构域或其邻域的特异性相互作用具有适合于阻断磷酸化事件的良好定义的结构。 本发明还包含含有这些化合物的药物组合物及其在制备用于治疗与肿瘤过程相关的疾病或病症的药物或试剂中的用途。
-
公开(公告)号：US08748411B2
公开(公告)日：2014-06-10
申请号：US11920031
申请日：2006-05-05
申请人： Rolando Eduardo Rodriguez Fernandez , Roberto Vera Alvarez , Ania De La Nuez Veulens , Yuliet Mazola Reyes , Silvio Ernesto Perea Rodriguez , Boris Ernesto Acevedo Castro , Alexis Musacchio Lasa , Raimundo Ubieta Gómez
发明人： Rolando Eduardo Rodriguez Fernandez , Roberto Vera Alvarez , Ania De La Nuez Veulens , Yuliet Mazola Reyes , Silvio Ernesto Perea Rodriguez , Boris Ernesto Acevedo Castro , Alexis Musacchio Lasa , Raimundo Ubieta Gómez
IPC分类号： A61K31/66 , A61K31/53 , A61K31/505 , A61K31/47 , A61K31/415 , A61K31/40 , C07D251/42 , C07D473/00 , C07D239/02 , C07D215/38 , C07D235/00 , C07D233/96 , C07D209/14 , C07D307/02 , C07D229/00 , C07F9/02 , C07C281/02 , C07C273/02 , C07C303/00 , C07C241/00
CPC分类号： C07C211/14 , C07C237/06 , C07C237/22 , C07C243/28 , C07C255/42 , C07C257/14 , C07C271/22 , C07C271/64 , C07C275/08 , C07C275/16 , C07C275/24 , C07C281/12 , C07C317/28 , C07C327/42 , C07C337/08 , C07D207/34 , C07D209/14 , C07D213/81 , C07D213/82 , C07D215/46 , C07D233/88 , C07D233/91 , C07D235/14 , C07D239/36 , C07D239/46 , C07D239/54 , C07D251/22 , C07D307/52 , C07D487/04 , C07F9/224
摘要： Chemical compounds derived by in silico molecular modelling, having a well defined structure suitable for the blocking of the phosphorylation event, through the specific interaction of the chemical with the Casein Kinase 2 enzyme substrate phosphorylation domain or it's neighbourhood. This invention comprises also the pharmaceutical compositions containing such compounds, and their use in the preparation of medicines or agents for the treatment of diseases or conditions related with neoplasic processes.
摘要翻译： 通过在硅分子模拟中得到的化学化合物通过化学物质与酪蛋白激酶2酶底物磷酸化结构域或其邻域的特异性相互作用具有适合于阻断磷酸化事件的良好定义的结构。 本发明还包含含有这些化合物的药物组合物及其在制备用于治疗与肿瘤过程相关的疾病或病症的药物或试剂中的用途。
-
公开(公告)号：US20130224313A1
公开(公告)日：2013-08-29
申请号：US13700286
申请日：2011-05-31
申请人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
发明人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
IPC分类号： A61K38/10 , A61K31/513 , A61K33/24 , G01N33/574 , A61K48/00 , C07K7/08
CPC分类号： C12N15/11 , A61K31/505 , A61K31/513 , A61K33/24 , A61K38/10 , A61K38/1767 , A61K45/06 , A61K48/00 , C07K7/08 , G01N33/574 , A61K2300/00
摘要： This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.
摘要翻译： 本发明描述了通过增加与降低或阻断癌细胞增殖相关的COMMD1蛋白的核定位来治疗癌症的方法。 本发明还涉及在制造用于癌症治疗的药物中增加COMMD1蛋白的核定位的试剂的用途。 这些试剂可以是其他化合物中的肽或蛋白质。 本发明还涉及来自序列HARIKPTFRRLKWKKYKGKFW的肽的优化，以增加蛋白质COMMD的核定位，从而提高该肽的抗肿瘤效果。
-
7.发明申请公开(公告)号：US20100316669A1
公开(公告)日：2010-12-16
申请号：US12430534
申请日：2009-04-27
申请人： Santiago Duenas Carrera , Juan Morales Grillo , Liz Alvarez-Lajonchere Ponce de Leon , Alexis Musacchio Lasa , Rolando Pajon Feyt , Ariel Vina Rodriguez , Julio C. Alvarez Obregon , Nelson Acosta Rivero , Gillian Martinez Donato
发明人： Santiago Duenas Carrera , Juan Morales Grillo , Liz Alvarez-Lajonchere Ponce de Leon , Alexis Musacchio Lasa , Rolando Pajon Feyt , Ariel Vina Rodriguez , Julio C. Alvarez Obregon , Nelson Acosta Rivero , Gillian Martinez Donato
IPC分类号： A61K39/29 , A61K39/00 , A61K39/295 , A61P31/14 , A61P31/20
CPC分类号： A61K39/29 , A61K39/12 , A61K39/292 , A61K2039/53 , A61K2039/55505 , A61K2039/70 , C12N2730/10134 , C12N2770/24234
摘要： Formulation of vaccine antigens, containing as main components: a-) one or several DNA expressing one or several proteins in the immunized individuals and b-) a viral antigen, in appropriate proportions. Development of new formulations, minimizing the number of components that enhance and diversify the spectrum of immune response against different pathogenic entities and generating combined vaccines against pathogens.These formulations can be applied in the pharmaceutical industry for preventive and-or therapeutic use in human.
摘要翻译： 包含作为主要成分的疫苗抗原的制剂：a-）在免疫个体中表达一种或几种蛋白质的一种或几种DNA，和b-以适当比例的病毒抗原。 开发新的配方，最大限度地减少增加和多样化针对不同病原体的免疫反应谱的组分数量，并产生抗病原体的联合疫苗。 这些制剂可以应用于制药工业中用于预防和/或治疗人类。
-
8.发明申请Methods and Proteins for the Prophylactic and/or Therapeutic Treatment of Four Serotypes of Dengue Virus and Other Flaviviruses 审中-公开用于预防和/或治疗四种登革热病毒和其他黄病毒血清型的方法和蛋白质公开(公告)号：US20090312190A1
公开(公告)日：2009-12-17
申请号：US12094503
申请日：2006-11-21
申请人： Glay Chinea Santiago , Vivian Huerta Galindo , Alejandro Miguel Martin Dunn , Jorge Victor Gavilondo Cowley , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Jeovanis Gil Valdés , Aída Zulueta Morales , Lisset Hermida Cruz , Marta Ayala Avila , Diamilé Gonzáles Roche , Rolando Paez Meireles , Patricia Gabriela Toledo Mayora , Mónica Sarria Núnez , Alexis Musacchio Lasa , Yuliet Mazola Reyes
发明人： Glay Chinea Santiago , Vivian Huerta Galindo , Alejandro Miguel Martin Dunn , Jorge Victor Gavilondo Cowley , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Jeovanis Gil Valdés , Aída Zulueta Morales , Lisset Hermida Cruz , Marta Ayala Avila , Diamilé Gonzáles Roche , Rolando Paez Meireles , Patricia Gabriela Toledo Mayora , Mónica Sarria Núnez , Alexis Musacchio Lasa , Yuliet Mazola Reyes
IPC分类号： C40B30/02 , A61K39/00 , A61K39/12 , C12N7/00 , C12N5/00 , C40B30/04 , C40B40/10 , C07K16/00 , C07H21/04 , A61K39/02
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/55566 , C07K2319/02 , C07K2319/21 , C12N2770/24022 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to the field of the pharmaceutical industry, and describes a conserved area on the surface of the E protein that can be used for the development of wide-spectrum antiviral molecules to be employed in the prophylaxis and/or treatment of infections due to Dengue Virus serotypes 1-4 and other flaviviruses. The invention also covers chimeric proteins to be used as vaccines or as a prophylactic or therapeutic treatment against the four serotypes of Dengue Virus and other flaviviruses.
摘要翻译： 本发明涉及制药工业的领域，并且描述了可用于开发用于预防和/或治疗感染的广谱抗病毒分子的E蛋白表面上的保守区域 由于登革热病毒血清型1-4和其他黄病毒。 本发明还涵盖用作疫苗的嵌合蛋白或针对登革热病毒和其他黄病毒的四种血清型的预防或治疗性治疗。
-
公开(公告)号：US08729226B2
公开(公告)日：2014-05-20
申请号：US13700286
申请日：2011-05-31
申请人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
发明人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
IPC分类号： A61K38/00
CPC分类号： C12N15/11 , A61K31/505 , A61K31/513 , A61K33/24 , A61K38/10 , A61K38/1767 , A61K45/06 , A61K48/00 , C07K7/08 , G01N33/574 , A61K2300/00
摘要： This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.
摘要翻译： 本发明描述了通过增加与降低或阻断癌细胞增殖相关的COMMD1蛋白的核定位来治疗癌症的方法。 本发明还涉及在制造用于癌症治疗的药物中增加COMMD1蛋白的核定位的试剂的用途。 这些试剂可以是其他化合物中的肽或蛋白质。 本发明还涉及来自序列HARIKPTFRRLKWKKYKGKFW的肽的优化，以增加蛋白质COMMD的核定位，从而提高该肽的抗肿瘤效果。
-
10.发明授权Chimerical peptidic molecules with antiviral properties against the viruses of the Flaviviridae family 有权具有针对黄病毒科病毒的抗病毒特性的嵌合肽分子公开(公告)号：US08674063B2
公开(公告)日：2014-03-18
申请号：US12513085
申请日：2007-10-30
申请人： Glay Chinea Santiago , Vivian Huerta Galindo , Alejandro Miguel Martin Dunn , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Mónica Sarría Núñez , Alexis Musacchio Lasa , Olvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Anìa Cabrales Rico
发明人： Glay Chinea Santiago , Vivian Huerta Galindo , Alejandro Miguel Martin Dunn , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Mónica Sarría Núñez , Alexis Musacchio Lasa , Olvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Anìa Cabrales Rico
IPC分类号： C07K14/00
CPC分类号： A61K47/48315 , A61K38/00 , A61K47/645 , C07K14/005 , C07K2319/04 , C07K2319/10 , C12N2770/24022 , C12N2770/24122 , C12N2770/24222 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： The present invention is relative to chimerical peptides, whose primary structure holds at least one segment which inhibits the activation of the NS3 protease of a virus from the Flaviviridae family, they also contain a cell penetrating segment and they are capable of inhibiting or attenuate the viral infection. This invention is also relative to pharmaceutical compounds which contain these chimerical peptides for the prevention and/or treatment of the infection caused by a virus of the Flaviviridae family.
摘要翻译： 本发明是相对于嵌合肽，其主要结构保持至少一个片段，其抑制来自黄病毒科的病毒的NS3蛋白酶的活化，它们还含有细胞穿透片段，并且它们能够抑制或减弱病毒 感染。 本发明还涉及含有这些嵌合肽用于预防和/或治疗由黄病毒科病毒引起的感染的药物化合物。
-
-
-
-
-
-
-
-
-
搜索结果
18 条记录 (耗时 0.018 秒)
