公开(公告)号：US08420311B2

公开(公告)日：2013-04-16

申请号：US12298808

申请日：2007-04-26

申请人： Vivian Huerta Galindo ,  Glay Chinea Santiago ,  Noralvis Fleitas Salazar ,  Alejandro Miguel Martin Dunn ,  Monica Sarria Nunez ,  Osmany Guirola Cruz ,  Patricia Gabriela Toledo Mayora ,  Aniel Sanchez Puente ,  Vladimir Armando Besada Perez ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Perez ,  Ania Cabrales Rico ,  Alexis Musacchio Lasa ,  Gabriel Ramon Padron Palomares ,  Luis Javier Gonzalez Lopez

发明人： Vivian Huerta Galindo ,  Glay Chinea Santiago ,  Noralvis Fleitas Salazar ,  Alejandro Miguel Martin Dunn ,  Monica Sarria Nunez ,  Osmany Guirola Cruz ,  Patricia Gabriela Toledo Mayora ,  Aniel Sanchez Puente ,  Vladimir Armando Besada Perez ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Perez ,  Ania Cabrales Rico ,  Alexis Musacchio Lasa ,  Gabriel Ramon Padron Palomares ,  Luis Javier Gonzalez Lopez

IPC分类号： C12Q1/70 ,  A61K39/12

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K14/70596 ,  C07K14/8107 ,  C12N2770/24122 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/394 ,  Y02A50/396

摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.

摘要翻译： 本发明涉及一种基于干扰病毒包膜蛋白与细胞受体的直接相互作用或其通过载体蛋白与所述细胞受体的间接相互作用而阻断登革热病毒感染细胞的方法，以及相关的 用途; 其中所述细胞受体是α-2巨球蛋白受体，也称为低密度受体相关蛋白或CD91，所述载体蛋白是人α-2巨球蛋白。