发明授权
- 专利标题： Tertiary amine substituted peptides useful as inhibitors of HCV replication
- 专利标题（中）： 可用作HCV复制抑制剂的叔胺取代肽
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申请号： US12597380申请日： 2008-02-26
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公开(公告)号： US08435984B2公开(公告)日： 2013-05-07
- 发明人: Atul Agarwal , Xiangzhu Wang , Dawei Chen , Suoming Zhang , Avinash Phadke
- 申请人： Atul Agarwal , Xiangzhu Wang , Dawei Chen , Suoming Zhang , Avinash Phadke
- 申请人地址： US CT New Haven
- 专利权人： Achillion Pharmaceuticals, Inc.
- 当前专利权人： Achillion Pharmaceuticals, Inc.
- 当前专利权人地址： US CT New Haven
- 代理机构： Cantor Colburn LLP
- 国际申请： PCT/US2008/002524 WO 20080226
- 国际公布： WO2008/106130 WO 20080904
- 主分类号： C07D401/00
- IPC分类号： C07D401/00 ; C07D405/00 ; C07D403/00 ; C07D217/00 ; A01N43/40 ; A61K31/445 ; A61K31/55
摘要：
The present invention provides tertiary amine substituted peptides of Formula (I) useful as inhibitors of HCV replication. The variables R and R1-R12 in Formula I are described herein. The invention also includes methods for preparing such compounds. The present invention further includes pharmaceutical compositions containing tertiary amine substituted peptides and methods for using such compounds, including methods for using the compounds to treat hepatitis C infection.