发明授权
US08470576B2 Group of novel enantioselective microbial nitrile hydratases with broad substrate specificity
失效
一组具有广泛底物特异性的新型对映选择性微生物腈水合酶
- 专利标题： Group of novel enantioselective microbial nitrile hydratases with broad substrate specificity
- 专利标题（中）： 一组具有广泛底物特异性的新型对映选择性微生物腈水合酶
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申请号： US12296057申请日： 2007-04-05
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公开(公告)号： US08470576B2公开(公告)日： 2013-06-25
- 发明人: Jürgen Eck , Klaus Liebeton , Lutz Fischer , Sabine Lutz-Wahl , Martina Hensel , Christian Ewert , Marcus Wälz
- 申请人： Jürgen Eck , Klaus Liebeton , Lutz Fischer , Sabine Lutz-Wahl , Martina Hensel , Christian Ewert , Marcus Wälz
- 申请人地址： DE Zwingenberg
- 专利权人： B.R.A.I.N. AG
- 当前专利权人： B.R.A.I.N. AG
- 当前专利权人地址： DE Zwingenberg
- 代理机构： Pillsbury Winthrop Shaw Pittman LLP
- 优先权： EP06007383 20060407
- 国际申请： PCT/EP2007/003114 WO 20070405
- 国际公布： WO2007/115797 WO 20071018
- 主分类号： C12N9/78
- IPC分类号： C12N9/78 ; C12N15/00 ; C12N1/20 ; C12P21/06 ; C12P21/04 ; C12Q1/68 ; C07H21/04
摘要：
The present invention provides a polynucleotide or a pair of polynucleotides encoding an enzyme having nitrile hydratase (NHase) [E.C. 4.2.1.84] activity. Furthermore, a vector and a host comprising the disclosed polynucleotide or pair of polynucleotides and methods for the production of the same are provided. Moreover, the invention relates to a pair of polypeptides or a fusion protein having NHase activity, an antibody specifically binding to the pair of polypeptides or fusion protein, a primer or probe, which specifically hybridizes under stringent conditions to the disclosed polynucleotide or either one of the pair of polynucleotides, a composition comprising the polynucleotide or pair of polynucleotides, the pair of polypeptides or fusion protein, the antibody and/or one or more primers or probes of the invention and a method for the production of amides comprising the enantioselective conversion of nitriles.
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