发明授权
- 专利标题： Process for making modulators of cystic fibrosis transmembrane conductance regulator
- 专利标题（中）： 制备囊性纤维化跨膜电导调节剂的方法
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申请号： US12728173申请日： 2010-03-19
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公开(公告)号： US08476442B2公开(公告)日： 2013-07-02
- 发明人: John DeMattei , Adam R. Looker , Bobbianna Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap , Brian R. Krueger , Peter D. J. Grootenhuis , Fredrick F. van Goor , Martyn C. Botfield , Gregor Zlokarnik
- 申请人： John DeMattei , Adam R. Looker , Bobbianna Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap , Brian R. Krueger , Peter D. J. Grootenhuis , Fredrick F. van Goor , Martyn C. Botfield , Gregor Zlokarnik
- 申请人地址： US MA Cambridge
- 专利权人： Vertex Pharmaceutical Incorporated
- 当前专利权人： Vertex Pharmaceutical Incorporated
- 当前专利权人地址： US MA Cambridge
- 代理机构： Honigman Miller Schwartz and Cohn LLP
- 代理商 Christopher C. Forbes, Ph.D.; Jonathan P. O'Brien, Ph.D.
- 主分类号： C07D215/233
- IPC分类号： C07D215/233 ; C07D215/00 ; C07D307/77 ; C07D307/00 ; A61K31/47
摘要：
The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.
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