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公开(公告)号:US20120309758A1
公开(公告)日:2012-12-06
申请号:US13492164
申请日:2012-06-08
申请人: Urvi Sheth , Lev T.D. Fanning , Mehdi Numa , Hayley Binch , Dennis James Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna R. Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick F. Van Goor , Peter Diederik Jan Grootenhuis , Martyn C. Botfield
发明人: Urvi Sheth , Lev T.D. Fanning , Mehdi Numa , Hayley Binch , Dennis James Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna R. Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick F. Van Goor , Peter Diederik Jan Grootenhuis , Martyn C. Botfield
IPC分类号: A61K31/47 , A61K31/4709 , C12N5/071 , C07D215/56 , C07D413/12 , A61K31/5377 , A61P29/00 , A61P25/08 , A61P25/16 , A61P25/28 , A61P25/00 , A61P3/00 , A61P11/00 , A61P1/18 , A61P19/10 , A61P3/10 , A61P27/02 , A61P11/06 , A61P15/08 , C07D401/12
CPC分类号: A61K31/4725 , A61K31/47 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D215/56 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K2300/00
摘要: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译: 本发明涉及ATP结合盒(ABC)转运蛋白或其片段的调节剂,包括囊性纤维化跨膜电导调节剂,其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号:US08802700B2
公开(公告)日:2014-08-12
申请号:US13492164
申请日:2012-06-08
申请人: Urvi Sheth , Lev T. D. Fanning , Mehdi Numa , Hayley Binch , Dennis James Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna R. Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick F. Van Goor , Peter Diederik Jan Grootenhuis , Martyn C. Botfield
发明人: Urvi Sheth , Lev T. D. Fanning , Mehdi Numa , Hayley Binch , Dennis James Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna R. Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick F. Van Goor , Peter Diederik Jan Grootenhuis , Martyn C. Botfield
IPC分类号: A61K31/04 , A61K31/4725 , A61K31/4709
CPC分类号: A61K31/4725 , A61K31/47 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D215/56 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K2300/00
摘要: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译: 本发明涉及ATP结合盒(“ABC”)转运蛋白或其片段的调节剂,包括囊性纤维化跨膜电导调节剂,其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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3.PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 有权
标题翻译: CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR制造调制器的工艺公开(公告)号:US20100267768A1
公开(公告)日:2010-10-21
申请号:US12728173
申请日:2010-03-19
申请人: John DeMattei , Adam R. Looker , Bobbianna Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap , Brian R. Krueger , Peter D.J. Grootenhuis , Fredrick F. van Goor , Martyn C. Botfield , Gregor Zlokarnik
发明人: John DeMattei , Adam R. Looker , Bobbianna Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap , Brian R. Krueger , Peter D.J. Grootenhuis , Fredrick F. van Goor , Martyn C. Botfield , Gregor Zlokarnik
IPC分类号: A61K31/47 , C07D215/233 , C07C69/96 , C07D307/77 , A61P11/06 , A61P1/18 , A61P15/10 , A61P37/08 , A61P1/16 , A61P3/00 , A61P25/28 , A61P3/10 , A61P37/00 , A61P7/12 , C12N5/07 , C12Q1/02
CPC分类号: C07C205/43 , C07C68/02 , C07C69/96 , C07C201/08 , C07C213/02 , C07C229/66 , C07D215/233 , C07D215/56 , G01N33/5041 , G01N33/6872 , Y02P20/55
摘要: The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.
摘要翻译: 本发明提供了制备式1化合物的方法,包括在偶联剂存在下将式2的羧酸与式3的苯胺偶联。
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4.Process for making modulators of cystic fibrosis transmembrane conductance regulator 有权
标题翻译: 制备囊性纤维化跨膜电导调节剂的方法公开(公告)号:US08476442B2
公开(公告)日:2013-07-02
申请号:US12728173
申请日:2010-03-19
申请人: John DeMattei , Adam R. Looker , Bobbianna Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap , Brian R. Krueger , Peter D. J. Grootenhuis , Fredrick F. van Goor , Martyn C. Botfield , Gregor Zlokarnik
发明人: John DeMattei , Adam R. Looker , Bobbianna Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap , Brian R. Krueger , Peter D. J. Grootenhuis , Fredrick F. van Goor , Martyn C. Botfield , Gregor Zlokarnik
IPC分类号: C07D215/233 , C07D215/00 , C07D307/77 , C07D307/00 , A61K31/47
CPC分类号: C07C205/43 , C07C68/02 , C07C69/96 , C07C201/08 , C07C213/02 , C07C229/66 , C07D215/233 , C07D215/56 , G01N33/5041 , G01N33/6872 , Y02P20/55
摘要: The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.
摘要翻译: 本发明提供了制备式1化合物的方法,包括在偶联剂存在下将式2的羧酸与式3的苯胺偶联。
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公开(公告)号:US20100028874A1
公开(公告)日:2010-02-04
申请号:US12298353
申请日:2007-04-25
申请人: Ravi K. Ramachandran , Matthew W. Harding , Paul R. Caron , Martyn C. Botfield , Brian J. Hare , Raj Bandaru , Kevin M. Kelliher , Catharine N. Cornell
发明人: Ravi K. Ramachandran , Matthew W. Harding , Paul R. Caron , Martyn C. Botfield , Brian J. Hare , Raj Bandaru , Kevin M. Kelliher , Catharine N. Cornell
CPC分类号: C12Q1/707 , C12Q2545/114
摘要: A signature set of genes associated with hepatitis C virus infection is described.
摘要翻译: 描述了与丙型肝炎病毒感染相关的基因的一组签名。
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