-
1.Process for making modulators of cystic fibrosis transmembrane conductance regulator 有权
标题翻译: 制备囊性纤维化跨膜电导调节剂的方法公开(公告)号:US08476442B2
公开(公告)日:2013-07-02
申请号:US12728173
申请日:2010-03-19
申请人: John DeMattei , Adam R. Looker , Bobbianna Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap , Brian R. Krueger , Peter D. J. Grootenhuis , Fredrick F. van Goor , Martyn C. Botfield , Gregor Zlokarnik
发明人: John DeMattei , Adam R. Looker , Bobbianna Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap , Brian R. Krueger , Peter D. J. Grootenhuis , Fredrick F. van Goor , Martyn C. Botfield , Gregor Zlokarnik
IPC分类号: C07D215/233 , C07D215/00 , C07D307/77 , C07D307/00 , A61K31/47
CPC分类号: C07C205/43 , C07C68/02 , C07C69/96 , C07C201/08 , C07C213/02 , C07C229/66 , C07D215/233 , C07D215/56 , G01N33/5041 , G01N33/6872 , Y02P20/55
摘要: The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.
摘要翻译: 本发明提供了制备式1化合物的方法,包括在偶联剂存在下将式2的羧酸与式3的苯胺偶联。
-
2.PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 有权
标题翻译: CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR制造调制器的工艺公开(公告)号:US20100267768A1
公开(公告)日:2010-10-21
申请号:US12728173
申请日:2010-03-19
申请人: John DeMattei , Adam R. Looker , Bobbianna Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap , Brian R. Krueger , Peter D.J. Grootenhuis , Fredrick F. van Goor , Martyn C. Botfield , Gregor Zlokarnik
发明人: John DeMattei , Adam R. Looker , Bobbianna Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap , Brian R. Krueger , Peter D.J. Grootenhuis , Fredrick F. van Goor , Martyn C. Botfield , Gregor Zlokarnik
IPC分类号: A61K31/47 , C07D215/233 , C07C69/96 , C07D307/77 , A61P11/06 , A61P1/18 , A61P15/10 , A61P37/08 , A61P1/16 , A61P3/00 , A61P25/28 , A61P3/10 , A61P37/00 , A61P7/12 , C12N5/07 , C12Q1/02
CPC分类号: C07C205/43 , C07C68/02 , C07C69/96 , C07C201/08 , C07C213/02 , C07C229/66 , C07D215/233 , C07D215/56 , G01N33/5041 , G01N33/6872 , Y02P20/55
摘要: The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.
摘要翻译: 本发明提供了制备式1化合物的方法,包括在偶联剂存在下将式2的羧酸与式3的苯胺偶联。
-
3.PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 审中-公开
标题翻译: CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR制造调制器的工艺公开(公告)号:US20120122921A1
公开(公告)日:2012-05-17
申请号:US13237359
申请日:2011-09-20
申请人: John DeMattei , Adam R. Looker , Bobbianna J. Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap Guerette , Brian R. Krueger , Peter Diederik Jan Grootenhuis , Fredrick F. Van Goor , Martyn Curtis Botfield , Gregor Zlokarnik
发明人: John DeMattei , Adam R. Looker , Bobbianna J. Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap Guerette , Brian R. Krueger , Peter Diederik Jan Grootenhuis , Fredrick F. Van Goor , Martyn Curtis Botfield , Gregor Zlokarnik
IPC分类号: A61K31/47 , C07D215/56 , C07D307/83 , A61P11/00 , A61P11/06 , A61P11/08 , A61P11/02 , A61P1/00 , A61P1/18 , A61P15/08 , A61P7/00 , A61P1/16 , A61P7/04 , A61P3/06 , A61P5/48 , A61P3/10 , A61P5/18 , A61P19/08 , A61P25/28 , A61P25/16 , A61P25/00 , A61P25/14 , A61P27/02 , A61P17/00 , C12N5/071 , C12Q1/02 , C07C68/00
CPC分类号: C07C205/43 , C07C68/02 , C07C69/96 , C07C201/08 , C07C213/02 , C07C229/66 , C07D215/233 , C07D215/56 , G01N33/5041 , G01N33/6872 , Y02P20/55
摘要: The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.
摘要翻译: 本发明提供了制备式1化合物的方法,包括在偶联剂存在下将式2的羧酸与式3的苯胺偶联。
-
4.PROCESSES FOR PRODUCING PHENYL-6-(1-(PHENYL)UREIDO)NICOTINAMIDES) 失效
标题翻译: 制备苯基-6-(1-(苯基)尿嘧啶)尼古丁的方法)公开(公告)号:US20100234606A1
公开(公告)日:2010-09-16
申请号:US12704903
申请日:2010-02-12
申请人: Stefanie Roeper , Adam R. Looker , Theodore A. Martinot , Bobbianna Neubert-Langille , Michael P. Ryan , John R. Snoonian
发明人: Stefanie Roeper , Adam R. Looker , Theodore A. Martinot , Bobbianna Neubert-Langille , Michael P. Ryan , John R. Snoonian
IPC分类号: C07D213/36 , C07D213/78
CPC分类号: C07D213/80 , C07D213/803
摘要: The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
摘要翻译: 本发明涉及制备可用作p38激酶抑制剂的化合物的方法。 本发明的方法适用于大规模制备,并以高纯度产生稳定的苯基-6-(1-(苯基)脲基)烟酰胺。
-
5.
公开(公告)号:US08273896B2
公开(公告)日:2012-09-25
申请号:US12704903
申请日:2010-02-12
申请人: Stefanie Roeper , Adam R. Looker , Theodore A. Martinot , Bobbianna Neubert-Langille , Michael P. Ryan , John R. Snoonian
发明人: Stefanie Roeper , Adam R. Looker , Theodore A. Martinot , Bobbianna Neubert-Langille , Michael P. Ryan , John R. Snoonian
IPC分类号: C07D213/36 , C07D213/78
CPC分类号: C07D213/80 , C07D213/803
摘要: The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
摘要翻译: 本发明涉及制备可用作p38激酶抑制剂的化合物的方法。 本发明的方法适用于大规模制备,并以高纯度产生稳定的苯基-6-(1-(苯基)脲基)烟酰胺。
-
6.
公开(公告)号:US08461345B2
公开(公告)日:2013-06-11
申请号:US13591380
申请日:2012-08-22
申请人: Stefanie Roeper , Adam R. Looker , Theodore A. Martinot , Bobbianna Neubert-Langille , Michael P. Ryan , John R. Snoonian
发明人: Stefanie Roeper , Adam R. Looker , Theodore A. Martinot , Bobbianna Neubert-Langille , Michael P. Ryan , John R. Snoonian
IPC分类号: C07D213/82 , C07D213/803
CPC分类号: C07D213/80 , C07D213/803
摘要: The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
摘要翻译: 本发明涉及制备可用作p38激酶抑制剂的化合物的方法。 本发明的方法适用于大规模制备,并以高纯度产生稳定的苯基-6-(1-(苯基)脲基)烟酰胺。
-
7.PROCESSES FOR PRODUCING PHENYL-6-(1-(PHENYL)UREIDO)NICOTINAMIDES) 失效
标题翻译: 制备苯基-6-(1-(苯基)尿嘧啶)尼古丁的方法)公开(公告)号:US20120316345A1
公开(公告)日:2012-12-13
申请号:US13591380
申请日:2012-08-22
申请人: Stefanie Roeper , Adam R. Looker , Theodore A. Martinot , Bobbianna Neubert-Langille , Michael P. Ryan , John R. Snoonian
发明人: Stefanie Roeper , Adam R. Looker , Theodore A. Martinot , Bobbianna Neubert-Langille , Michael P. Ryan , John R. Snoonian
IPC分类号: C07D213/82 , C07D213/803
CPC分类号: C07D213/80 , C07D213/803
摘要: The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
摘要翻译: 本发明涉及制备可用作p38激酶抑制剂的化合物的方法。 本发明的方法适用于大规模制备,并以高纯度产生稳定的苯基-6-(1-(苯基)脲基)烟酰胺。
-
公开(公告)号:US08362253B2
公开(公告)日:2013-01-29
申请号:US13413327
申请日:2012-03-06
申请人: John DeMattei , Yushi Feng , Cristian L. Harrison , Adam R. Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
发明人: John DeMattei , Yushi Feng , Cristian L. Harrison , Adam R. Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
IPC分类号: C07D215/38 , A61K31/04
CPC分类号: C07D215/56 , A61K31/47 , A61K45/06 , C07D215/233
摘要: Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.
-
9.SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 有权
标题翻译: N- [2,4-BIS(1,1-二甲基乙基)-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-羧酰胺的固体形式公开(公告)号:US20120165372A1
公开(公告)日:2012-06-28
申请号:US13413327
申请日:2012-03-06
申请人: John DeMattei , Yushi Feng , Cristian Harrison , Adam Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
发明人: John DeMattei , Yushi Feng , Cristian Harrison , Adam Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
IPC分类号: A61K31/47 , A61P11/00 , A61P7/04 , A61P3/06 , A61P7/00 , A61P3/10 , A61P5/18 , A61P35/00 , A61P5/14 , A61P25/28 , A61P25/16 , A61P25/00 , A61P25/14 , A61P27/04 , A61P17/00 , C07D215/56
CPC分类号: C07D215/56 , A61K31/47 , A61K45/06 , C07D215/233
摘要: Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.
摘要翻译: 本文描述了固体形式的N- [2,4-双(1,1-二甲基乙基)-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺,包括其结晶形式。
-
10.Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxypheny1]-1,4-dihydro-4-oxoquinoline-3-carboxamide 有权
标题翻译: 固体形式的N- [2,4-双(1,1-二甲基乙基)-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺公开(公告)号:US08163772B2
公开(公告)日:2012-04-24
申请号:US12283702
申请日:2008-09-15
申请人: John DeMattei , Yushi Feng , Cristian Harrison , Adam Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
发明人: John DeMattei , Yushi Feng , Cristian Harrison , Adam Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
IPC分类号: C07D215/38 , A61K31/04
CPC分类号: C07D215/56 , A61K31/47 , A61K45/06 , C07D215/233
摘要: Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.
摘要翻译: 本文描述了固体形式的N- [2,4-双(1,1-二甲基乙基)-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺,包括其结晶形式。
-
-
-
-
-
-
-
-
-