发明授权
- 专利标题： Tetrahydroisoquinolin-1-one derivative or salt thereof
- 专利标题（中）： 四氢异喹啉-1-酮衍生物或其盐
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申请号： US12600894申请日： 2008-05-26
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公开(公告)号： US08486970B2公开(公告)日： 2013-07-16
- 发明人: Hiroyuki Hisamichi , Itsuro Shimada , Tsukasa Ishihara , Tomofumi Takuwa , Takafumi Shimizu , Noriko Ishikawa , Kyoichi Maeno , Norio Seki
- 申请人： Hiroyuki Hisamichi , Itsuro Shimada , Tsukasa Ishihara , Tomofumi Takuwa , Takafumi Shimizu , Noriko Ishikawa , Kyoichi Maeno , Norio Seki
- 申请人地址： US NJ Bridgewater
- 专利权人： Seldar Pharma Inc.
- 当前专利权人： Seldar Pharma Inc.
- 当前专利权人地址： US NJ Bridgewater
- 代理机构： Foley & Lardner LLP
- 优先权： JPP2007-140097 20070528
- 国际申请： PCT/JP2008/059621 WO 20080526
- 国际公布： WO2008/146774 WO 20081204
- 主分类号： A01N43/40
- IPC分类号： A01N43/40 ; A61K31/445
摘要：
[Problems] To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS).[Means for Solving Problems] It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.
公开/授权文献
- US20100227866A1 TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF 公开/授权日：2010-09-09
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