发明授权
US08541033B2 Production of human antibodies using NOD/SCID/γcnull mice
失效
使用NOD / SCID / gammacnull小鼠生产人抗体
- 专利标题： Production of human antibodies using NOD/SCID/γcnull mice
- 专利标题（中）： 使用NOD / SCID / gammacnull小鼠生产人抗体
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申请号： US12620469申请日： 2009-11-17
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公开(公告)号： US08541033B2公开(公告)日： 2013-09-24
- 发明人: Mamoru Ito , Kimio Kobayashi , Tatsutoshi Nakahata , Koichiro Tsuji , Sonoko Habu , Yoshio Koyanagi , Naoki Yamamoto , Kazuo Sugamura , Kiyoshi Ando , Tatsuji Nomura
- 申请人： Mamoru Ito , Kimio Kobayashi , Tatsutoshi Nakahata , Koichiro Tsuji , Sonoko Habu , Yoshio Koyanagi , Naoki Yamamoto , Kazuo Sugamura , Kiyoshi Ando , Tatsuji Nomura
- 申请人地址： JP Kanagawa
- 专利权人： Central Institute for Experimental Animals
- 当前专利权人： Central Institute for Experimental Animals
- 当前专利权人地址： JP Kanagawa
- 代理机构： Arnold & Porter LLP
- 代理商 Ginger R. Dreger; Victoria L. Boyd
- 优先权： JP2000-367296 20001201
- 主分类号： A61K35/28
- IPC分类号： A61K35/28 ; C12P21/00 ; A01K67/00
摘要：
The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor γ-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
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