发明授权
US08546112B2 Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester
失效
5-甲基-3-硝基甲基 - 己酸酯的立体选择性酶水解的方法
- 专利标题： Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester
- 专利标题（中）： 5-甲基-3-硝基甲基 - 己酸酯的立体选择性酶水解的方法
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申请号： US12993132申请日： 2009-05-19
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公开(公告)号： US08546112B2公开(公告)日： 2013-10-01
- 发明人: Martin Albert , Ferdinand Zepeck , Andreas Berger , Waander Riethorst , Helmut Schwab , Daniel Luschnig , Peter Remler , Joerg Salchenegger , Doris Osl , Dominic De Souza
- 申请人： Martin Albert , Ferdinand Zepeck , Andreas Berger , Waander Riethorst , Helmut Schwab , Daniel Luschnig , Peter Remler , Joerg Salchenegger , Doris Osl , Dominic De Souza
- 申请人地址： CH Basel
- 专利权人： Sandoz AG
- 当前专利权人： Sandoz AG
- 当前专利权人地址： CH Basel
- 代理机构： Manelli Selter PLLC
- 代理商 Jeffrey S. Melcher
- 国际申请： PCT/EP2009/056099 WO 20090519
- 国际公布： WO2009/141362 WO 20091126
- 主分类号： C12P13/04
- IPC分类号： C12P13/04
摘要：
The present invention relates to processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid ester and its salts. Also disclosed are processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid salt and a process for the preparation of 3-(aminomethyl)-5-methylhexanoic acid. (S)-5-Methyl-3-nitromethyl-hexanoic acid or (R)-5-methyl-3-nitromethyl-hexanoic acid in enantioenriched form or enantiopure form as well as salts thereof, (S)-5-methyl-3-nitromethyl-hexanoic acid ester or (R)-5-methyl-3-nitromethyl-hexanoic acid ester in enantioenriched form or enantiopure form and a compound, namely Formula (XIII), in racemic form, enantioenriched form or enantiopure form are also disclosed.
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