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    Carbonyl asymmetric alkylation
    4.
    发明授权
    Carbonyl asymmetric alkylation 有权
    羰基不对称烷基化

    公开(公告)号：US08288569B2

    公开(公告)日：2012-10-16

    申请号：US12223096

    申请日：2007-01-22

    申请人： Martin Albert ,  Hubert Sturm ,  Andreas Berger ,  Peter Kremminger

    发明人： Martin Albert ,  Hubert Sturm ,  Andreas Berger ,  Peter Kremminger

    IPC分类号： C07D307/87 ,  C07F5/02

    CPC分类号： C07C255/56 ,  C07C215/30 ,  C07C255/53 ,  C07D307/87

    摘要： This invention relates to processes and intermediates for the stereoselective alkylation of carbonyl groups. The invention in particular allows the stereoselective preparation of the antidepressant drug escitalopram. It has been found that boric or boronic acid derivatives are useful bridging elements for the attachment of a chiral group to a compound containing a carbonyl group to be alkylated. The said borates and boronates are thus useful in a process for the asymmetric alkylation of a carbonyl group in a compound containing a carbonyl group and an anchor group capable of reacting with a boric or boronic acid derivative. The asymmetric alkylation can be carried out by admixing the compound containing a carbonyl group to be alkylated and the anchor group capable of reacting with a boric or boronic acid derivative with a boric or boronic acid derivative, adding a chiral alcohol, and adding an organometallic compound. After the alkylation reaction, the borate and boronate can be easily removed by hydrolysis.

    摘要翻译： 本发明涉及羰基的立体选择性烷基化方法和中间体。 本发明特别允许立体选择性制备抗抑郁药物依他普仑。 已经发现硼酸或硼酸衍生物是用于将手性基团连接到含有待烷基化羰基的化合物的有用的桥连元件。 因此，所述硼酸盐和硼酸盐可用于在含有羰基和能够与硼酸或硼酸衍生物反应的锚定基团的化合物中羰基的不对称烷基化方法。 不对称烷基化可以通过将待烷基化的羰基和能够与硼酸或硼酸衍生物反应的锚定基团与硼酸或硼酸衍生物反应，加入手性醇，并加入有机金属化合物 。 在烷基化反应之后，可以通过水解容易地除去硼酸盐和硼酸盐。

    Carbonyl Asymmetric Alkylation
    5.
    发明申请
    Carbonyl Asymmetric Alkylation 有权
    羰基不对称烷基化

    公开(公告)号：US20110009648A1

    公开(公告)日：2011-01-13

    申请号：US12223096

    申请日：2007-01-22

    申请人： Martin Albert ,  Hubert Sturm ,  Andreas Berger ,  Peter Kremminger

    发明人： Martin Albert ,  Hubert Sturm ,  Andreas Berger ,  Peter Kremminger

    IPC分类号： C07D307/87 ,  C07C253/30 ,  C07C255/59 ,  C07C213/08 ,  C07F5/02 ,  C07C29/38 ,  C07C215/20 ,  C07C31/38

    CPC分类号： C07C255/56 ,  C07C215/30 ,  C07C255/53 ,  C07D307/87

    摘要： This invention relates to processes and intermediates for the stereoselective alkylation of carbonyl groups. The invention in particular allows the stereoselective preparation of the antidepressant drug escitalopram. It has been found that boric or boronic acid derivatives are useful bridging elements for the attachment of a chiral group to a compound containing a carbonyl group to be alkylated. The said borates and boronates are thus useful in a process for the asymmetric alkylation of a carbonyl group in a compound containing a carbonyl group and an anchor group capable of reacting with a boric or boronic acid derivative. The asymmetric alkylation can be carried out by admixing the compound containing a carbonyl group to be alkylated and the anchor group capable of reacting with a boric or boronic acid derivative with a boric or boronic acid derivative, adding a chiral alcohol, and adding an organometallic compound. After the alkylation reaction, the borate and boronate can be easily removed by hydrolysis.

    摘要翻译： 本发明涉及羰基的立体选择性烷基化方法和中间体。 本发明特别允许立体选择性制备抗抑郁药物依他普仑。 已经发现硼酸或硼酸衍生物是用于将手性基团连接到含有待烷基化羰基的化合物的有用的桥连元件。 因此，所述硼酸盐和硼酸盐可用于在含有羰基和能够与硼酸或硼酸衍生物反应的锚定基团的化合物中羰基的不对称烷基化方法。 不对称烷基化可以通过将待烷基化的羰基和能够与硼酸或硼酸衍生物反应的锚定基团与硼酸或硼酸衍生物反应，加入手性醇，并加入有机金属化合物 。 在烷基化反应之后，可以通过水解容易地除去硼酸盐和硼酸盐。

    Flow Measuring Device
    7.
    发明申请
    Flow Measuring Device 有权
    流量测量装置

    公开(公告)号：US20130269448A1

    公开(公告)日：2013-10-17

    申请号：US13996075

    申请日：2011-12-01

    申请人： Andreas Berger ,  Pierre Ueberschlag

    发明人： Andreas Berger ,  Pierre Ueberschlag

    IPC分类号： G01F1/66

    CPC分类号： G01F1/662

    摘要： Flow measuring device for ascertaining flow of a measured medium flowing through a measuring tube, which flow measuring device has a first housing for protruding into the measured medium, wherein the first housing has a first surface intended to face the measured medium, wherein the flow measuring device includes a second surface for bounding the measured medium, and wherein each separation between the first surface for bounding the first housing from measured medium, the second surface for bounding the measured medium and the first surface of the first housing amounts to at least 1 mm.

    摘要翻译： 用于确定流过测量管的测量介质的流动的流量测量装置，所述流量测量装置具有用于突出到所述测量介质中的第一壳体，其中所述第一壳体具有旨在面向所述测量介质的第一表面，其中所述流量测量 装置包括用于界定所测量的介质的第二表面，并且其中用于将第一壳体与测量介质结合的第一表面之间的每个间隔，用于限定测量介质的第二表面和第一壳体的第一表面的距离至少为1mm 。

    Coupling element of a sensor of an ultrasonic, flow measuring device
    8.
    发明授权
    Coupling element of a sensor of an ultrasonic, flow measuring device 有权
    超声波传感器的耦合元件，流量测量装置

    公开(公告)号：US08560252B2

    公开(公告)日：2013-10-15

    申请号：US12950085

    申请日：2010-11-19

    申请人： Andreas Berger ,  Frank Wandeler ,  Achim Wiest

    发明人： Andreas Berger ,  Frank Wandeler ,  Achim Wiest

    IPC分类号： G01F1/00 ,  G01D18/00

    CPC分类号： B06B3/00 ,  G01F1/662

    摘要： A coupling element of a sensor of an ultrasonic, flow measuring device, which includes at least three rods having, in each case, a first rod end and a second rod end. The rods, in each case, have, on their respective first ends, first end faces, which, in each case, can be acoustically coupled with the sound-emitting and/or sound-receiving area of an ultrasonic transducer element. The respective first end faces of the rods together form a first coupling surface of the coupling element, and the rods, in each case, have, on their respective second ends, second end faces, which form a second coupling surface of the coupling element, wherein the rods, in each case, have a first rod cross section, which is different in shape and/or size from a respective second rod cross section.

    摘要翻译： 超声波测量装置的传感器的耦合元件，其包括至少三个杆，每个杆在每种情况下具有第一杆端和第二杆端。 在每种情况下，杆在它们各自的第一端具有在每种情况下可以与超声换能器元件的发声和/或声音接收区域声学耦合的第一端面。 杆的相应的第一端面一起形成联接元件的第一联接表面，并且在每种情况下，杆在它们各自的第二端具有形成联接元件的第二联接表面的第二端面， 其中，在每种情况下，所述杆具有与相应的第二杆横截面不同的形状和/或尺寸的第一杆横截面。

    Coupling element of a sensor of an ultrasonic, flow measuring device
    9.
    发明申请
    Coupling element of a sensor of an ultrasonic, flow measuring device 有权
    超声波传感器的耦合元件，流量测量装置

    公开(公告)号：US20110118995A1

    公开(公告)日：2011-05-19

    申请号：US12950085

    申请日：2010-11-19

    申请人： Andreas Berger ,  Frank Wandeler ,  Achim Wiest

    发明人： Andreas Berger ,  Frank Wandeler ,  Achim Wiest

    IPC分类号： G01F1/66

    CPC分类号： B06B3/00 ,  G01F1/662

    摘要： A coupling element of a sensor of an ultrasonic, flow measuring device, which includes at least three rods having, in each case, a first rod end and a second rod end. The rods, in each case, have, on their respective first ends, first end faces, which, in each case, can be acoustically coupled with the sound-emitting and/or sound-receiving area of an ultrasonic transducer element. The respective first end faces of the rods together form a first coupling surface of the coupling element, and the rods, in each case, have, on their respective second ends, second end faces, which form a second coupling surface of the coupling element, wherein the rods, in each case, have a first rod cross section, which is different in shape and/or size from a respective second rod cross section.

    摘要翻译： 超声波测量装置的传感器的耦合元件，其包括至少三个杆，每个杆在每种情况下具有第一杆端和第二杆端。 在每种情况下，杆在它们各自的第一端具有在每种情况下可以与超声换能器元件的发声和/或声音接收区域声学耦合的第一端面。 杆的相应的第一端面一起形成联接元件的第一联接表面，并且在每种情况下，杆在它们各自的第二端具有形成联接元件的第二联接表面的第二端面， 其中，在每种情况下，所述杆具有与相应的第二杆横截面不同的形状和/或尺寸的第一杆横截面。

    Device for Determining and/or Monitoring a Volume Flow and/or a Mass Flow
    10.
    发明申请
    Device for Determining and/or Monitoring a Volume Flow and/or a Mass Flow 审中-公开
    用于确定和/或监测体积流量和/或质量流量的装置

    公开(公告)号：US20090095088A1

    公开(公告)日：2009-04-16

    申请号：US11795894

    申请日：2005-12-16

    申请人： Andreas Berger ,  Achim Wiest ,  Patrick Oudoire

    发明人： Andreas Berger ,  Achim Wiest ,  Patrick Oudoire

    IPC分类号： G01F1/00

    CPC分类号： G01F1/662

    摘要： An apparatus for ascertaining and/or monitoring volume- and/or mass-flow of a measured medium flowing in a flow direction through a measuring tube of predetermined inner diameter. The apparatus includes a plurality of ultrasonic sensors, which transmit and/or receive ultrasonic measuring signals along different, defined measuring paths, and a control/evaluation unit, which ascertains volume- and/or mass-flow of the measured medium in a pipeline/in the measuring tube on the basis of the ultrasonic measuring signals according to a sound entrainment method or the echo principle. At least two ultrasonic sensors, which transmit and/or receive the ultrasonic measuring signals on different measuring paths, are positioned in an opening located in the wall of the measuring tube.

    摘要翻译： 用于确定和/或监测沿流动方向流过预定内径的测量管的测量介质的体积和/或质量流量的装置。 该设备包括多个超声波传感器，其传送和/或接收沿着不同的定义的测量路径的超声波测量信号，以及控制/评估单元，其确定测量的介质在管道中的体积和/或质量流量， 在测量管中基于超声波测量信号，根据声音夹带方法或回波原理。 在不同测量路径上传输和/或接收超声波测量信号的至少两个超声波传感器位于测量管壁中的开口中。