发明授权
- 专利标题： Mycobacterial mutants inducing IL-12
- 专利标题（中）： 分枝杆菌突变体诱导IL-12
-
申请号： US12450193申请日： 2008-03-10
-
公开(公告)号： US08591918B2公开(公告)日： 2013-11-26
- 发明人: William R. Jacobs, Jr. , Kari Sweeney , Dee Dao , Steven A. Porcelli , John Chan , Tsungda Hsu
- 申请人： William R. Jacobs, Jr. , Kari Sweeney , Dee Dao , Steven A. Porcelli , John Chan , Tsungda Hsu
- 申请人地址： US NY Bronx
- 专利权人： Albert Einstein College of Medicine of Yeshiva University
- 当前专利权人： Albert Einstein College of Medicine of Yeshiva University
- 当前专利权人地址： US NY Bronx
- 代理机构： Amster, Rothstein & Ebenstein LLP
- 国际申请： PCT/US2008/003204 WO 20080310
- 国际公布： WO2009/008912 WO 20090115
- 主分类号： A61K39/04
- IPC分类号： A61K39/04 ; A61K49/00 ; A01N63/00
摘要：
Provided are mycobacteria deleted in at least a portion of a region 3 ESAT-6-like gene cluster. Also provided are mycobacteria comprising a mutation in an roc-1 gene. Additionally, vaccines comprising these mycobacteria are provided. Further provided are methods of making a recombinant mycobacterium, methods of inducing an immune response in a mammal, methods of inhibiting IL-12 production in a mammal, and methods of stimulating IL-12 production in a mammal. Vaccine adjuvants are also provided, as are methods of inducing immunity to a target antigen in a mammal.
公开/授权文献
- US20120141533A1 MYCOBACTERIAL MUTANTS INDUCING IL-12 公开/授权日：2012-06-07
信息查询
