公开(公告)号：US08591918B2

公开(公告)日：2013-11-26

申请号：US12450193

申请日：2008-03-10

申请人： William R. Jacobs, Jr. ,  Kari Sweeney ,  Dee Dao ,  Steven A. Porcelli ,  John Chan ,  Tsungda Hsu

发明人： William R. Jacobs, Jr. ,  Kari Sweeney ,  Dee Dao ,  Steven A. Porcelli ,  John Chan ,  Tsungda Hsu

IPC分类号： A61K39/04 ,  A61K49/00 ,  A01N63/00

CPC分类号： C07K14/35

摘要： Provided are mycobacteria deleted in at least a portion of a region 3 ESAT-6-like gene cluster. Also provided are mycobacteria comprising a mutation in an roc-1 gene. Additionally, vaccines comprising these mycobacteria are provided. Further provided are methods of making a recombinant mycobacterium, methods of inducing an immune response in a mammal, methods of inhibiting IL-12 production in a mammal, and methods of stimulating IL-12 production in a mammal. Vaccine adjuvants are also provided, as are methods of inducing immunity to a target antigen in a mammal.

摘要翻译： 提供在区域3 ESAT-6样基因簇的至少一部分中缺失分枝杆菌。 还提供了包含roc-1基因突变的分枝杆菌。 另外，提供了包含这些分枝杆菌的疫苗。 进一步提供了制备重组分枝杆菌的方法，在哺乳动物中诱导免疫应答的方法，抑制哺乳动物中IL-12产生的抑制方法，以及刺激哺乳动物中IL-12产生的方法。 还提供疫苗佐剂，以及在哺乳动物中诱导免疫目标抗原的方法。

公开(公告)号：US20120141533A1

公开(公告)日：2012-06-07

申请号：US12450193

申请日：2008-03-10

申请人： William R. Jacobs, JR. ,  Kari Sweeney ,  Dee Dao ,  Steven A. Porcelli ,  John Chan ,  Tsungda Hsu

发明人： William R. Jacobs, JR. ,  Kari Sweeney ,  Dee Dao ,  Steven A. Porcelli ,  John Chan ,  Tsungda Hsu

IPC分类号： A61K35/74 ,  A61P37/04 ,  C12N1/21

CPC分类号： C07K14/35

摘要： Provided are mycobacteria deleted in at least a portion of a region 3 ESAT-6-like gene cluster. Also provided are mycobacteria comprising a mutation in an roc-1 gene. Additionally, vaccines comprising these mycobacteria are provided. Further provided are methods of making a recombinant mycobacterium, methods of inducing an immune response in a mammal, methods of inhibiting IL-12 production in a mammal, and methods of stimulating IL-12 production in a mammal. Vaccine adjuvants are also provided, as are methods of inducing immunity to a target antigen in a mammal.

摘要翻译： 提供在区域3 ESAT-6样基因簇的至少一部分中缺失分枝杆菌。 还提供了包含roc-1基因突变的分枝杆菌。 另外，提供了包含这些分枝杆菌的疫苗。 进一步提供了制备重组分枝杆菌的方法，在哺乳动物中诱导免疫应答的方法，抑制哺乳动物中IL-12产生的抑制方法，以及刺激哺乳动物中IL-12产生的方法。 还提供疫苗佐剂，以及在哺乳动物中诱导免疫目标抗原的方法。

公开(公告)号：US20230349414A1

公开(公告)日：2023-11-02

申请号：US18220663

申请日：2023-07-11

申请人： John Chan ,  Rong Chen

发明人： John Chan ,  Rong Chen

IPC分类号： F16B39/282 ,  F16B39/24 ,  F16B35/04

CPC分类号： F16B39/282 ,  F16B39/24 ,  F16B35/041

摘要： An anti-loosening fastener includes a bolt including a head and a screw tail, a first washer configured to fit around the screw tail of the bolt, a first nut configured to screw onto the screw tail of the bolt, a second nut configured to screw onto the screw tail of the bolt, a first cutting surface located on the screw tail of the bolt. A first surface of the first washer includes one or more wedge-shaped helical teeth, and a first surface of the first nut includes one or more wedge-shaped helical teeth. The bolt, the first washer, the first nut, the second nut, and the cutting surface are capable of affixing a component. The anti-loosening fastener may also include a second cutting surface located on the screw tail of the bolt.

公开(公告)号：US20080006549A1

公开(公告)日：2008-01-10

申请号：US11825981

申请日：2007-07-09

申请人： John Chan

发明人： John Chan

IPC分类号： A61C17/22

CPC分类号： A61C17/225 ,  A61C17/22 ,  A61C17/221 ,  A61C2202/00 ,  H01H9/06 ,  H01H15/102 ,  H01H25/00

摘要： An actuator assembly and packaging feature for an electric toothbrush is disclosed. The actuator assembly includes a positionable member accessible along the outer surface of the toothbrush body. The actuator assembly further includes a spring member retained within the interior of the toothbrush body which urges a cam member against the underside of the positionable member. The positionable member defines an aperture extending through its midsection within which is disposed a depressible member. The depressible member has an outer end which is also accessible along the outer surface of the toothbrush body. Upon pressing the depressible member, the cam member and spring are urged against an electrical circuit provided within the body of the toothbrush which is used to selectively operate a motor and drive mechanism to move one or more sets of bristles. The actuator assembly additionally includes a feature of providing a raised region along an outer surface of the positionable member which guards against accidental or unintentional depressing of the depressible member. The packaging feature relates to a member formed in a package cover that is suitably sized and positioned over the depressible member of the actuator so that the cover, when pressed, may momentarily activate the toothbrush within the package.

摘要翻译： 公开了一种用于电动牙刷的致动器组件和包装特征。 致动器组件包括可沿着牙刷本体的外表面接近的可定位构件。 致动器组件还包括保持在牙刷本体内部的弹簧构件，其将凸轮构件推压抵靠可定位构件的下侧。 可定位构件限定延伸穿过其中部的孔，在其中设置有可压下的构件。 可压下的构件具有外端，其也可以沿着牙刷本体的外表面接近。 在按压可按压的构件时，凸轮构件和弹簧被推靠在设置在牙刷主体内的电路，该电路用于选择性地操作马达和驱动机构以移动一组或多组刷毛。 致动器组件还包括沿着可定位构件的外表面提供凸起区域的特征，其防止可压下构件的意外或无意的压下。 包装特征涉及形成在包装盖中的构件，其被适当地定尺寸并且被定位在致动器的可压下构件上方，使得盖被按压时可以暂时激活包装内的牙刷。

公开(公告)号：US20060257822A1

公开(公告)日：2006-11-16

申请号：US11488204

申请日：2006-07-18

申请人： Chanchal Ghosh ,  Satyanarayana Majeti ,  Aleksey Pinyayev ,  John Chan ,  Alan Willey

发明人： Chanchal Ghosh ,  Satyanarayana Majeti ,  Aleksey Pinyayev ,  John Chan ,  Alan Willey

IPC分类号： A61C5/00

CPC分类号： A61C17/222 ,  A46B15/0002 ,  A46B15/0036 ,  A46B2200/1066 ,  A61C1/088 ,  A61C17/22 ,  A61C17/3436 ,  A61C17/349 ,  A61C19/063 ,  A61C19/066 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0606 ,  A61N2005/0651 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2224/49113 ,  H01L2924/00014

摘要： Disclosed is a method for providing an oral care benefit by combining the use of an oral care composition with an electric toothbrush having an electrically powered element disposed thereon. In particular methods are described for using an electric toothbrush comprising a light emitting element, with oral care compositions to provide tooth whitening and stain removal.

摘要翻译： 公开了一种通过组合使用口腔护理组合物与其上设置有电力元件的电动牙刷来提供口腔护理益处的方法。 具体描述了使用包括发光元件的电动牙刷和口腔护理组合物来提供牙齿增白和去污的方法。

公开(公告)号：US20060117505A1

公开(公告)日：2006-06-08

申请号：US11295907

申请日：2005-12-07

申请人： John Chan

发明人： John Chan

IPC分类号： A61C17/22

CPC分类号： A61C17/3472 ,  A61C17/349

摘要： An electric toothbrush is provided. The electric toothbrush has a handle, a head with a carriers and a longitudinal axis, and a neck disposed between the handle and the head. A motor is disposed within the handle. A shaft is operatively connected to the motor. The shaft is operatively connected to the carrier to move the carrier in a first motion. The carrier is capable of moving in a second motion when subjected to user forces.

摘要翻译： 提供电动牙刷。 电动牙刷具有手柄，具有托架和纵向轴线的头部以及设置在手柄和头部之间的颈部。 电机设置在手柄内。 轴可操作地连接到电动机。 轴可操作地连接到载体以在第一运动中移动载体。 当受到使用者的力量时，载体能够以第二动作移动。

公开(公告)号：US20060048315A1

公开(公告)日：2006-03-09

申请号：US11220219

申请日：2005-09-06

申请人： John Chan ,  Douglas Gall

发明人： John Chan ,  Douglas Gall

IPC分类号： A61C17/22

CPC分类号： A61C17/349 ,  A61C17/3436 ,  A61C17/3454

摘要： An electric toothbrush is provided. The electric toothbrush has a handle, a head with first and second bristle holders and a longitudinal axis, and a neck disposed between the handle and the head. A motor is disposed within the handle. A shaft is operatively connected to the motor. The shaft pivots in a side-to-side direction and is operatively connected to the first and second bristle holders to move the second bristle holder in a side-to-side direction and to oscillate the first bristle holder about an axis generally perpendicular to the longitudinal axis of the head.

摘要翻译： 提供电动牙刷。 电动牙刷具有手柄，头部具有第一和第二刷毛保持器和纵向轴线，以及设置在手柄和头部之间的颈部。 电机设置在手柄内。 轴可操作地连接到电动机。 轴以一个侧向方向枢转并且可操作地连接到第一和第二刷毛保持器以使第二刷毛支架沿着侧向方向移动，并使第一刷毛支架围绕大致垂直于 头部纵轴。

公开(公告)号：US20050273952A1

公开(公告)日：2005-12-15

申请号：US11206542

申请日：2005-08-18

申请人： John Chan ,  Wang Ping

发明人： John Chan ,  Wang Ping

IPC分类号： A46B9/04 ,  A46B13/02 ,  A61C17/22 ,  A61C17/34

CPC分类号： A46B9/04 ,  A46B13/02 ,  A46B15/0032 ,  A61C17/222 ,  A61C17/3436 ,  A61C17/3445 ,  A61C17/349

摘要： An electric toothbrush is provided. The electric toothbrush has an elongate body having a handle, a head, and a neck extending between the handle and the head. The body has an interior chamber with a motor. A shaft is operatively connected to the motor. A first movable bristle carrier is disposed on the head. The shaft is operatively connected to the first bristle carrier to impart motion thereto. The first bristle carrier has a first composite tuft formed from a plurality of closely spaced bristle tufts and a plurality of second bristle tufts. The second tufts have a height that is greater than a height of the first composite tuft. The bristles of the first composite tuft having free ends and the bristles of the second tufts having free ends. The total surface area of the bristles of the first composite tuft is greater than the total surface area of the bristles of the second tufts, and the plurality of second tufts are disposed adjacent a portion of a perimeter of the composite tuft to form a first recessed region.

摘要翻译： 提供电动牙刷。 电动牙刷具有细长主体，其具有手柄，头部和在手柄和头部之间延伸的颈部。 车身有一个带有马达的内室。 轴可操作地连接到电动机。 第一可移动的刷毛载体设置在头部上。 轴可操作地连接到第一刷毛载体以赋予其运动。 第一刷毛载体具有由多个紧密间隔的刷毛簇和多个第二刷毛簇形成的第一复合刷毛簇。 第二簇具有大于第一复合簇的高度的高度。 具有自由端的第一复合簇的刷毛和具有自由端的第二簇的刷毛。 第一复合毛簇的刷毛的总表面积大于第二毛簇的刷毛的总表面积，并且多个第二毛簇邻近复合毛簇的周边的一部分设置，以形成第一凹陷 地区。

公开(公告)号：US20050066459A1

公开(公告)日：2005-03-31

申请号：US10887644

申请日：2004-07-09

申请人： Aleksey Pinyayev ,  John Chan

发明人： Aleksey Pinyayev ,  John Chan

IPC分类号： A61C17/22 ,  A61C17/26 ,  A61C17/34 ,  A61C19/06 ,  A61N5/06

CPC分类号： A61C17/34 ,  A61C17/22 ,  A61C17/26 ,  A61C19/063 ,  A61C19/066 ,  A61N2005/0651

摘要： Disclosed is an electric toothbrush having an electrically powered element disposed on the head, and at least one removable and replaceable component. In particular is disclosed an electric toothbrush having removable and replaceable bristle holder, which can be removed and replaced without removing the electrically powered element from the head of the toothbrush.

摘要翻译： 公开了一种电动牙刷，其具有设置在头部上的电动元件，以及至少一个可拆卸和可更换部件。 具体地，公开了一种具有可移除和可替换的刷毛支架的电动牙刷，其可以被移除和更换，而不从牙刷的头部移除电动元件。

公开(公告)号：US20050050659A1

公开(公告)日：2005-03-10

申请号：US10888206

申请日：2004-07-09

申请人： John Chan ,  Chanchal Ghosh ,  Stephen Kovacs ,  Lowen Morrision ,  Ping Wang ,  Aleksey Pinyayev

发明人： John Chan ,  Chanchal Ghosh ,  Stephen Kovacs ,  Lowen Morrision ,  Ping Wang ,  Aleksey Pinyayev

IPC分类号： A46B15/00 ,  A61C1/08 ,  A61C17/22 ,  A61C17/34 ,  A61C19/06 ,  A61N5/06 ,  H01L25/075

CPC分类号： A61C17/222 ,  A46B15/0002 ,  A46B15/0036 ,  A46B2200/1066 ,  A61C1/088 ,  A61C17/22 ,  A61C17/3436 ,  A61C17/349 ,  A61C19/063 ,  A61C19/066 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0606 ,  A61N2005/0651 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2224/49113 ,  H01L2924/00014

摘要： A toothbrush having an electrically powered element disposed on a head of an electric toothbrush. The electrically powered element can be a light emitting element such as a light emitting diode. Further the electrically powered element can serve as a pin and/or axis of motion for a movable bristle holder positioned along the face of the brush head.

摘要翻译： 一种具有设置在电动牙刷的头部上的电动元件的牙刷。 电动元件可以是诸如发光二极管的发光元件。 此外，电动元件可以用作沿着刷头的表面定位的可移动刷毛支架的销和/或运动轴线。