Invention Grant
- Patent Title: Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
- Patent Title (中): 嘧啶环戊烷作为AKT蛋白激酶抑制剂
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Application No.: US12667848Application Date: 2008-07-03
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Publication No.: US08618097B2Publication Date: 2013-12-31
- Inventor: Josef Bencsik , James F. Blake , James M. Graham , Martin F. Hentemann , Nicholas C. Kallan , Ian S. Mitchell , Stephen T. Schlachter , Keith L. Spencer , Dengming Xiao , Rui Xu , Mike Welch , Jun Liang , Brian S. Safina
- Applicant: Josef Bencsik , James F. Blake , James M. Graham , Martin F. Hentemann , Nicholas C. Kallan , Ian S. Mitchell , Stephen T. Schlachter , Keith L. Spencer , Dengming Xiao , Rui Xu , Mike Welch , Jun Liang , Brian S. Safina
- Applicant Address: US CO Boulder US CA South San Francisco
- Assignee: Array Biopharma, Inc.,Genentech, Inc.
- Current Assignee: Array Biopharma, Inc.,Genentech, Inc.
- Current Assignee Address: US CO Boulder US CA South San Francisco
- Agency: Viksnins Harris & Padys PLLP
- International Application: PCT/US2008/069144 WO 20080703
- International Announcement: WO2009/006567 WO 20090108
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K31/496 ; C07D413/14 ; C07D239/70 ; A61P25/28 ; A61P35/00 ; A61P29/00 ; A61P9/00
Abstract:
The present invention provides compounds of Formula (I), including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Public/Granted literature
- US20110015204A1 PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS Public/Granted day:2011-01-20
Information query
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