发明授权
US08648050B2 Methods and formulations for reducing amphotericin B treatment side effects
有权
减少两性霉素B治疗副作用的方法和制剂
- 专利标题： Methods and formulations for reducing amphotericin B treatment side effects
- 专利标题（中）： 减少两性霉素B治疗副作用的方法和制剂
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申请号： US12985256申请日： 2011-01-05
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公开(公告)号： US08648050B2公开(公告)日： 2014-02-11
- 发明人: John D. Cleary , Stanley W. Chapman , Robert E. Kramer
- 申请人： John D. Cleary , Stanley W. Chapman , Robert E. Kramer
- 申请人地址： US MS University
- 专利权人： University of Mississippi
- 当前专利权人： University of Mississippi
- 当前专利权人地址： US MS University
- 代理机构： Stites & Harbison PLLC
- 代理商 Richard S. Myers, Jr.
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; C07H17/08
摘要：
A method of ameliorating amphotericin treatment side effects in a mammal that comprises administering a therapeutically effective amount of a formulation that comprises a polyene active ingredient that includes amphotericin B, wherein the amphotericin B compound is present, in terms of polyene content, in an amount greater than 90%, and non-amphotericin B polyene compounds are present in an amount of no greater than 10%, and a pharmaceutically effective carrier; and administering a therapeutically effective amount of said formulation to a subject in need thereof.
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