公开(公告)号：US07000480B2

公开(公告)日：2006-02-21

申请号：US10762701

申请日：2004-01-23

申请人： Robert E. Kramer

发明人： Robert E. Kramer

IPC分类号： G01L7/00

CPC分类号： G05D7/00 ,  F24F11/30 ,  F24F2110/00 ,  F24F2110/30

摘要： An air flow control device, such as an air diffuser (21) with a differential pressure sensing assembly. The diffuser (21) has a housing (29) formed for mounting to a supply air conduit (22) for discharge of supply air (54) into a room (56). The differential pressure sensing assembly includes a diffuser-mounted portion (41) and a detachable sensor portion (40). The diffuser mounted portion (41) is provided by a pressure tube (42) having at least one opening (43) therein mounted to the housing (29) with the opening (43) positioned proximate an area of known cross section to communicate pressure at the opening (43) to an open distal end (46) of the tube (42). The distal end (46) is secured in a position accessible from a room side (51) of the housing (29). The distal end (46) of the tube (42) is formed for releasable coupling of the detachable sensor portion (40) of the differential pressure sensing assembly thereto, and the sensor portion includes a differential pressure measurement device (61) for measurement of the difference between the supply air pressure in the diffuser (21) at the known area and the ambient room air pressure. This measurement is made from a room side (51) of the housing (29) and allows a determination of the supply air flow rate through the diffuser to be made. A method of measuring air flow rate in an air flow control device (21) is also disclosed.

摘要翻译： 气流控制装置，例如具有差压感测组件的空气扩散器（21）。 扩散器（21）具有形成为用于安装到供应空气管道（22）上以将供应空气（54）排放到房间（56）中的壳体（29）。 差压感测组件包括扩散器安装部分（41）和可拆卸的传感器部分（40）。 扩散器安装部分（41）由压力管（42）提供，其中至少一个开口（43）安装在壳体（29）上，开口（43）位于已知横截面的区域附近，以将压力 所述开口（43）连接到所述管（42）的开放的远端（46）。 远端（46）固定在从外壳（29）的房间侧（51）可接近的位置。 管（42）的远端（46）形成为用于将差压感测组件的可拆卸传感器部分（40）可释放地联接到其上，并且传感器部分包括差压测量装置（61） 在已知区域的扩散器（21）中的供应空气压力与周围室内空气压力之间的差异。 该测量由壳体（29）的室侧（51）进行，并且允许确定通过扩散器的供应空气流量。 还公开了一种测量空气流量控制装置（21）中的空气流量的方法。

公开(公告)号：US20110152211A1

公开(公告)日：2011-06-23

申请号：US12985256

申请日：2011-01-05

申请人： John D. Cleary ,  Stanley W. Chapman ,  Robert E. Kramer

发明人： John D. Cleary ,  Stanley W. Chapman ,  Robert E. Kramer

IPC分类号： A61K31/7048 ,  A61P31/10

CPC分类号： A61K31/7048

摘要： A method of ameliorating amphotericin treatment side effects in a mammal that comprises administering a therapeutically effective amount of a formulation that comprises a polyene active ingredient that includes amphotericin B, wherein the amphotericin B compound is present, in terms of polyene content, in an amount greater than 90%, and non-amphotericin B polyene compounds are present in an amount of no greater than 10%, and a pharmaceutically effective carrier; and administering a therapeutically effective amount of said formulation to a subject in need thereof.

摘要翻译： 一种改善哺乳动物两性霉素治疗副作用的方法，其包括施用治疗有效量的制剂，所述制剂包含多烯活性成分，所述多烯活性成分包括两性霉素B，其中所述两性霉素B化合物以多烯含量计，其量更大 90％以上，非两性霉素B多烯化合物以不大于10％的量存在，以及药学上有效的载体; 以及向有需要的受试者施用治疗有效量的所述制剂。

公开(公告)号：US07867981B2

公开(公告)日：2011-01-11

申请号：US10529622

申请日：2003-10-03

申请人： John D. Cleary ,  Stanley W. Chapman ,  Robert E. Kramer

发明人： John D. Cleary ,  Stanley W. Chapman ,  Robert E. Kramer

IPC分类号： A61K31/70

CPC分类号： A61K31/7048

摘要： A method for treating fungal infections in a mammal that includes administering a therapeutically effective amount of a composition comprising substantially pure amphotericin B and a pharmaceutically acceptable carrier. Amphotericin BHP is associated with decreased toxicity in mammals and cells measured by cell viability and expression of cytokine markers. Thus, this method allows for reduced adverse reactions when using amphotericin B products.

摘要翻译： 一种用于治疗哺乳动物真菌感染的方法，其包括施用治疗有效量的包含基本上纯的两性霉素B和药学上可接受的载体的组合物。 两性霉素BHP与通过细胞活力和细胞因子标记物表达测量的哺乳动物和细胞中的毒性降低相关。 因此，当使用两性霉素B产品时，该方法可以减少不良反应。

公开(公告)号：US08648050B2

公开(公告)日：2014-02-11

申请号：US12985256

申请日：2011-01-05

申请人： John D. Cleary ,  Stanley W. Chapman ,  Robert E. Kramer

发明人： John D. Cleary ,  Stanley W. Chapman ,  Robert E. Kramer

IPC分类号： A61K31/70 ,  C07H17/08

CPC分类号： A61K31/7048

摘要： A method of ameliorating amphotericin treatment side effects in a mammal that comprises administering a therapeutically effective amount of a formulation that comprises a polyene active ingredient that includes amphotericin B, wherein the amphotericin B compound is present, in terms of polyene content, in an amount greater than 90%, and non-amphotericin B polyene compounds are present in an amount of no greater than 10%, and a pharmaceutically effective carrier; and administering a therapeutically effective amount of said formulation to a subject in need thereof.

摘要翻译： 一种改善哺乳动物两性霉素治疗副作用的方法，其包括施用治疗有效量的制剂，所述制剂包含多烯活性成分，所述多烯活性成分包括两性霉素B，其中所述两性霉素B化合物以多烯含量计，其量更大 90％以上，非两性霉素B多烯化合物以不大于10％的量存在，以及药学上有效的载体; 以及向有需要的受试者施用治疗有效量的所述制剂。