Invention Grant
- Patent Title: Kinesin inhibitors as cancer therapeutics
- Patent Title (中): 驱动蛋白抑制剂作为癌症治疗剂
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Application No.: US13546713Application Date: 2012-07-11
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Publication No.: US08664256B2Publication Date: 2014-03-04
- Inventor: Tinya Abrams , Paul A. Barsanti , David Duhl , Michel Faure , Paul A. Renhowe , Annette Olga Walter
- Applicant: Tinya Abrams , Paul A. Barsanti , David Duhl , Michel Faure , Paul A. Renhowe , Annette Olga Walter
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Michael G. Smith
- Main IPC: A61K31/4164
- IPC: A61K31/4164
Abstract:
The invention provides novel compounds having a substituted imidazole ring, and methods of using such compounds for the treatment of certain disorders such as hematological cancers and solid tumors. The compounds of the invention are tri-substituted imidazole derivatives that inhibit KSP. These compounds are also useful for the treatment of drug resistant tumors, such as solid tumors that express elevated levels of P-glycoprotein.
Public/Granted literature
- US20130012560A1 KINESIN INHIBITORS AS CANCER THERAPEUTICS Public/Granted day:2013-01-10
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