Invention Grant
- Patent Title: Inhibitors of AKT activity
- Patent Title (中): AKT活性抑制剂
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Application No.: US13262096Application Date: 2010-03-29
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Publication No.: US08691825B2Publication Date: 2014-04-08
- Inventor: Qi Chen , Mingxiang Cui , Bin Hu , Shuangxi Hu , Zhifa Pu , Philip E. Sanderson , Richard Soll , Xue Tang , Jiabing Wang , Yongjin Yan , Jinfeng Yao , Hongjie Zhang
- Applicant: Qi Chen , Mingxiang Cui , Bin Hu , Shuangxi Hu , Zhifa Pu , Philip E. Sanderson , Richard Soll , Xue Tang , Jiabing Wang , Yongjin Yan , Jinfeng Yao , Hongjie Zhang
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Yong Zhao; Laura M. Ginkel
- International Application: PCT/US2010/028989 WO 20100329
- International Announcement: WO2010/114780 WO 20101007
- Main IPC: A01N43/90
- IPC: A01N43/90 ; A61K31/519 ; C07D487/00
Abstract:
The instant invention provides for substituted fused pyrimidine compounds of Formula A that inhibit Akt activity: In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
Public/Granted literature
- US20120077810A1 Inhibitors Of AKT Activity Public/Granted day:2012-03-29
Information query
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