专利检索 ap:("Qi Chen" OR "Mingxiang Cui" OR "Bin Hu" OR "Shuangxi Hu" OR "Zhifa Pu" OR "Philip E. Sanderson" OR "Richard Soll" OR "Xue Tang" OR "Jiabing Wang" OR "Yongjin Yan" OR "Jinfeng Yao" OR "Hongjie Zhang") AND inv:"Shuangxi Hu" 第 1 页

1.

发明申请
Inhibitors Of AKT Activity 有权
标题翻译： AKT活性抑制剂

公开(公告)号：US20120077810A1

公开(公告)日：2012-03-29

申请号：US13262096

申请日：2010-03-29

申请人： Qi Chen , Mingxiang Cui , Bin Hu , Shuangxi Hu , Zhifa Pu , Philip E. Sanderson , Richard Soll , Xue Tang , Jiabing Wang , Yongjin Yan , Jinfeng Yao , Hongjie Zhang

发明人： Qi Chen , Mingxiang Cui , Bin Hu , Shuangxi Hu , Zhifa Pu , Philip E. Sanderson , Richard Soll , Xue Tang , Jiabing Wang , Yongjin Yan , Jinfeng Yao , Hongjie Zhang

IPC分类号： A61K31/5377 , A61K31/519 , A61P35/00 , C07D487/04

CPC分类号： A61K31/44 , C07D487/04

摘要： The instant invention provides for substituted fused pyrimidine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

摘要翻译： 本发明提供抑制Akt活性的取代的稠合嘧啶化合物。特别地，所公开的化合物选择性地抑制一种或两种Akt同种型。本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。

2.

发明授权
Inhibitors of AKT activity 有权
标题翻译： AKT活性抑制剂

公开(公告)号：US08691825B2

公开(公告)日：2014-04-08

申请号：US13262096

申请日：2010-03-29

申请人： Qi Chen , Mingxiang Cui , Bin Hu , Shuangxi Hu , Zhifa Pu , Philip E. Sanderson , Richard Soll , Xue Tang , Jiabing Wang , Yongjin Yan , Jinfeng Yao , Hongjie Zhang

发明人： Qi Chen , Mingxiang Cui , Bin Hu , Shuangxi Hu , Zhifa Pu , Philip E. Sanderson , Richard Soll , Xue Tang , Jiabing Wang , Yongjin Yan , Jinfeng Yao , Hongjie Zhang

IPC分类号： A01N43/90 , A61K31/519 , C07D487/00

CPC分类号： A61K31/44 , C07D487/04

摘要： The instant invention provides for substituted fused pyrimidine compounds of Formula A that inhibit Akt activity: In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

摘要翻译： 本发明提供了抑制Akt活性的式A的取代的稠合嘧啶化合物：特别地，所公开的化合物选择性地抑制一种或两种Akt同种型。本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。