发明授权
- 专利标题： Modulation of antibody effector function by hinge domain engineering
- 专利标题（中）： 通过铰链域工程调节抗体效应子功能
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申请号： US13190199申请日： 2011-07-25
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公开(公告)号： US08697396B2公开(公告)日： 2014-04-15
- 发明人: William Dall'Acqua , Herren Wu , Melissa Damschroder , Jose Casas-Finet
- 申请人： William Dall'Acqua , Herren Wu , Melissa Damschroder , Jose Casas-Finet
- 申请人地址： US MD Gaithersburg
- 专利权人： MedImmune, LLC
- 当前专利权人： MedImmune, LLC
- 当前专利权人地址： US MD Gaithersburg
- 主分类号： C12P21/04
- IPC分类号： C12P21/04 ; C12N15/00 ; C07K16/00
摘要：
The present invention relates to novel molecules (Fc variants) comprising at least one antigen binding region and an Fc region that further comprises a modified hinge which alters the binding of Fc to one or more Fc ligand (e.g., FcγRs) and/or modulates effector function. More specifically, this invention provides Fc variants that have modified binding affinity to one or more FcγR and/or C1q. Additionally, the Fc variants have altered antibody-dependent cell-mediated cytotoxicity (ADCC) and/or complement dependent cytotoxicity (CDC) activity. The invention further provides methods and protocols for the application of said Fc variants particularly for therapeutic purposes.
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