发明授权
- 专利标题： HCV/GBV-B chimeric virus
- 专利标题（中）： HCV / GBV-B嵌合病毒
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申请号： US13054356申请日： 2009-07-15
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公开(公告)号： US08741607B2公开(公告)日： 2014-06-03
- 发明人: Noboru Maki , Kenichi Mori , Hiromi Fukai
- 申请人： Noboru Maki , Kenichi Mori , Hiromi Fukai
- 申请人地址： JP Wako-Shi
- 专利权人： Advanced Life Science Institute, Inc.
- 当前专利权人： Advanced Life Science Institute, Inc.
- 当前专利权人地址： JP Wako-Shi
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 优先权： JP2008-184179 20080715
- 国际申请： PCT/JP2009/062786 WO 20090715
- 国际公布： WO2010/008010 WO 20100121
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; C12N5/10 ; C12N7/00 ; C07K14/18
摘要：
An HCV/GBV-B chimeric virus which maintains the replication function of HCV and is capable of infecting tamarin is disclosed in order to construct an HCV animal model which can be used as a development or evaluation system for therapeutic agents for HCV. The HCV/GBV-B chimeric RNA comprises an RNA of hepatitis C virus and an RNA of GB virus-B, wherein the RNA of hepatitis C virus comprises an RNA encoding leucine at the 1804th position and lysine at the 1966th position in the amino acid sequence of the polyprotein of hepatitis C virus.
公开/授权文献
- US20110289610A1 HCV/GBV-B CHIMERIC VIRUS 公开/授权日：2011-11-24
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