Invention Grant
US08791101B2 Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
有权
芳基和杂芳基取代的四氢苯并氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取
- Patent Title: Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
- Patent Title (中): 芳基和杂芳基取代的四氢苯并氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取
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Application No.: US12917066Application Date: 2010-11-01
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Publication No.: US08791101B2Publication Date: 2014-07-29
- Inventor: Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
- Applicant: Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
- Applicant Address: US NY Albany US NJ Princeton
- Assignee: Albany Molecular Research, Inc.,Bristol-Myers Squibb Company
- Current Assignee: Albany Molecular Research, Inc.,Bristol-Myers Squibb Company
- Current Assignee Address: US NY Albany US NJ Princeton
- Agency: LeClairRyan, a Professional Corporation
- Main IPC: A61K31/55
- IPC: A61K31/55 ; C07D401/04
Abstract:
The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
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