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1.发明申请公开(公告)号：US20130237490A2
公开(公告)日：2013-09-12
申请号：US12884650
申请日：2010-09-17
Applicant: Grant J. CARR , David D. MANNING , Zhicai YANG , Cheng GUO , Jun-Ho MAENG , John RABENSTEIN , Peter C. MICHELS , Matthew W. CHASE
Inventor： Grant J. CARR , David D. MANNING , Zhicai YANG , Cheng GUO , Jun-Ho MAENG , John RABENSTEIN , Peter C. MICHELS , Matthew W. CHASE
IPC: A61K31/706 , A61K31/704 , A61K31/7056 , C12N1/20 , A61P31/04 , A61P43/00 , C12P19/28 , C07H5/06 , A61K31/7048
CPC classification number: C07H15/252 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K31/706 , C07H5/06 , C12P7/66 , C12P19/28 , C12R1/465
Abstract: The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.
Abstract translation: 本发明涉及具有抗菌活性的新型治疗剂，其制备方法以及含有它们作为活性成分的药物，兽医和营养组合物。 本发明还涉及新型治疗剂例如用作治疗细菌感染的药物或食品添加剂或辅助受试者体内体重增加的用途。
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公开(公告)号：US08501729B2
公开(公告)日：2013-08-06
申请号：US13372967
申请日：2012-02-14
Applicant: David D. Manning , Christopher Lawrence Cioffi
Inventor： David D. Manning , Christopher Lawrence Cioffi
IPC: C07D471/06 , C07D487/06 , C07D519/00 , A61K31/55 , A61P25/00
CPC classification number: A61K31/55 , A61K31/437 , A61K31/439 , C07D451/14 , C07D453/02 , C07D471/06 , C07D487/06 , C07D519/00
Abstract: Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.
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公开(公告)号：US08450307B2
公开(公告)日：2013-05-28
申请号：US11628569
申请日：2005-06-06
Applicant: Bruce J. Sargent , Henry Pauls , Judd M. Berman , Jailall Ramnauth , Peter Sampson , Andras Toro , Fernando J. Martin , Matthew D. Surman , Helene Y. Decornez , David D. Manning
Inventor： Bruce J. Sargent , Henry Pauls , Judd M. Berman , Jailall Ramnauth , Peter Sampson , Andras Toro , Fernando J. Martin , Matthew D. Surman , Helene Y. Decornez , David D. Manning
IPC: C07D401/12 , C07D405/12 , C07D409/12 , C07D498/04 , A61K31/551 , A61K31/5365
CPC classification number: C07D498/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D471/14
Abstract: In part, the present invention is directed to antibacterial compounds.
Abstract translation: 部分地，本发明涉及抗菌化合物。
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4.发明申请公开(公告)号：US20120010163A1
公开(公告)日：2012-01-12
申请号：US12884650
申请日：2010-09-17
Applicant: GRANT J. CARR , DAVID D. MANNING , ZHICAL YANG , CHENG GUO , JUN-HO MAENG , JOHN RABENSTEIN , PETER C. MICHELS , MATTHEW W. CHASE
Inventor： GRANT J. CARR , DAVID D. MANNING , ZHICAL YANG , CHENG GUO , JUN-HO MAENG , JOHN RABENSTEIN , PETER C. MICHELS , MATTHEW W. CHASE
IPC: A61K31/706 , A61K31/704 , A61K31/7056 , C12N1/20 , A61P31/04 , A61P43/00 , C12P19/28 , C07H5/06 , A61K31/7048
CPC classification number: C07H15/252 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K31/706 , C07H5/06 , C12P7/66 , C12P19/28 , C12R1/465
Abstract: The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.
Abstract translation: 本发明涉及具有抗菌活性的新型治疗剂，其制备方法以及含有它们作为活性成分的药物，兽医和营养组合物。 本发明还涉及新型治疗剂例如用作治疗细菌感染的药物或食品添加剂或辅助受试者体内体重增加的用途。
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公开(公告)号：US20100093705A1
公开(公告)日：2010-04-15
申请号：US11628569
申请日：2005-06-06
Applicant: Bruce J. Sargent , Henry Pauls , Judd M. Berman , Jailall Ramnauth , Peter Sampson , Andras Toro , Fernando J. Martin , Matthew D. Surman , Helene Y. Decornez , David D. Manning
Inventor： Bruce J. Sargent , Henry Pauls , Judd M. Berman , Jailall Ramnauth , Peter Sampson , Andras Toro , Fernando J. Martin , Matthew D. Surman , Helene Y. Decornez , David D. Manning
IPC: A61K31/551 , C07D471/04 , C07D223/16 , C07D491/02 , A61K31/4375 , A61P31/04
CPC classification number: C07D498/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D471/14
Abstract: In part, the present invention is directed to antibacterial compounds.
Abstract translation: 部分地，本发明涉及抗菌化合物。
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Patent Agency Ranking
6.发明授权Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin 有权芳基和杂芳基取代的四氢苯并氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取公开(公告)号：US08791101B2
公开(公告)日：2014-07-29
申请号：US12917066
申请日：2010-11-01
Applicant: Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
Inventor： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
IPC: A61K31/55 , C07D401/04
CPC classification number: C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04
Abstract: The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
Abstract translation: 本发明的化合物由以下芳基 - 和杂芳基取代的四氢苯并吖庚因和具有式I（AE）和式（II）的二氢苯并氮杂衍生物表示：其中指定为*的碳原子为R或S构型， X和R 1 -R 9如本文所定义。
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公开(公告)号：US08754054B2
公开(公告)日：2014-06-17
申请号：US12884650
申请日：2010-09-17
Applicant: Grant J. Carr , David D. Manning , Zhicai Yang , Cheng Guo , Jun-Ho Maeng , Peter C. Michels , Matthew W. Chase
Inventor： Grant J. Carr , David D. Manning , Zhicai Yang , Cheng Guo , Jun-Ho Maeng , Peter C. Michels , Matthew W. Chase
CPC classification number: C07H15/252 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K31/706 , C07H5/06 , C12P7/66 , C12P19/28 , C12R1/465
Abstract: The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.
Abstract translation: 本发明涉及具有抗菌活性的新型治疗剂，其制备方法以及含有它们作为活性成分的药物，兽医和营养组合物。 本发明还涉及新型治疗剂例如用作治疗细菌感染的药物或食品添加剂或辅助受试者体内体重增加的用途。
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公开(公告)号：US08710046B2
公开(公告)日：2014-04-29
申请号：US13384050
申请日：2010-06-30
Applicant: Peter R. Guzzo , David D. Manning , William Earley
Inventor： Peter R. Guzzo , David D. Manning , William Earley
IPC: C07D487/04 , C07D403/04 , A61K31/5517 , A61P25/00
CPC classification number: C07D513/06 , A61K31/439 , A61K31/55 , A61K31/5517 , A61K45/06 , C07D453/02 , C07D487/04 , C07D513/04
Abstract: Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.
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9.发明申请ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN 有权ARYL-和HETEROARYL取代的四氢苯并噻吩并用于阻断肾上腺素，多巴胺和丝氨酸蛋白酶公开(公告)号：US20110046114A1
公开(公告)日：2011-02-24
申请号：US12917066
申请日：2010-11-01
Applicant: Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
Inventor： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
CPC classification number: C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04
Abstract: The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
Abstract translation: 本发明的化合物由以下芳基 - 和杂芳基取代的四氢苯并吖庚因和具有式I（AE）和式（II）的二氢苯并氮杂衍生物表示：其中指定为*的碳原子为R或S构型， X和R 1 -R 9如本文所定义。
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公开(公告)号：US07863271B2
公开(公告)日：2011-01-04
申请号：US11835178
申请日：2007-08-07
Applicant: Zhicai Yang , David D. Manning
Inventor： Zhicai Yang , David D. Manning
IPC: A61K31/5377 , A61K31/439 , A61K31/496 , A61P1/08 , A61P25/00 , C07D453/02 , C07D413/14
CPC classification number: C07D453/02 , C07D451/04 , C07D453/06 , C07D471/08 , C07D498/08
Abstract: Compounds of formulae I, II and III: are disclosed as 5-HT3 inhibitors. The compounds are useful in treating CINV, IBS-D and other diseases and conditions.
Abstract translation: 式I，II和III的化合物：公开为5-HT 3抑制剂。 该化合物可用于治疗CINV，IBS-D等疾病和病症。
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