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公开(公告)号：US20130178459A1
公开(公告)日：2013-07-11
申请号：US13202544
申请日：2011-03-29
申请人： Yusuke Nakamura , Yo Matsuo , Shoji Hisada , Feryan Ahmed , Raymond Huntley , Zohreh Sajjadi-Hashemi , David M. Jenkins , Robert B. Kargbo , Wenge Cui , Polivina Jolicia F. Gauuan , Joel R. Walker , Helene Decornez , Mahender Gurram
发明人： Yusuke Nakamura , Yo Matsuo , Shoji Hisada , Feryan Ahmed , Raymond Huntley , Zohreh Sajjadi-Hashemi , David M. Jenkins , Robert B. Kargbo , Wenge Cui , Polivina Jolicia F. Gauuan , Joel R. Walker , Helene Decornez , Mahender Gurram
IPC分类号： C07D495/04 , C07D401/10 , C07D221/16
CPC分类号： C07D495/04 , C07D213/64 , C07D221/06 , C07D221/16 , C07D401/04 , C07D401/10 , C07D487/04 , C07D513/04 , C07D519/00
摘要： Tricyclic compounds are provided. These compounds are PBK inhibitors, and are useful for the treatment of PBK related diseases, including cancer.
摘要翻译： 提供三环化合物。 这些化合物是PBK抑制剂，可用于治疗包括癌症在内的PBK相关疾病。
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2.发明授权Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin 有权芳基和杂芳基取代的四氢苯并-1,4-二氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取公开(公告)号：US09096546B2
公开(公告)日：2015-08-04
申请号：US12598882
申请日：2008-05-08
申请人： Peter R. Guzzo , Bruce F. Molino , Wenge Cui , Shuang Liu , Richard E. Olson , Larry Yet
发明人： Peter R. Guzzo , Bruce F. Molino , Wenge Cui , Shuang Liu , Richard E. Olson , Larry Yet
IPC分类号： A61K31/5513 , C07D243/14 , C07D401/02 , C07D403/02 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/14 , C07D471/04
CPC分类号： C07D243/14 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/14 , C07D471/04
摘要： The aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepine derivative compounds of the present invention are represented by formulae 1(A-D) having the following structure: where the substituents X and R1-R8 are as defined herein.
摘要翻译： 本发明的芳基 - 和杂芳基取代的四氢苯并-1,4-二氮杂衍生物化合物由具有以下结构的式1（A-D）表示：其中取代基X和R 1 -R 8如本文所定义。
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3.发明申请Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin 有权芳基和杂芳基取代的四氢苯并氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取公开(公告)号：US20070021408A1
公开(公告)日：2007-01-25
申请号：US11487884
申请日：2006-07-17
申请人： Bruce Molino , Shuang Liu , Aruna Sambandam , Peter Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David Manning , Matthew Isherwood , Kristen Fleming , Wenge Cui , Richard Olson
发明人： Bruce Molino , Shuang Liu , Aruna Sambandam , Peter Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David Manning , Matthew Isherwood , Kristen Fleming , Wenge Cui , Richard Olson
IPC分类号： A61K31/55 , C07D487/02 , C07D403/02
CPC分类号： C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
摘要翻译： 本发明的化合物由以下芳基 - 和杂芳基取代的四氢苯并吖庚因和具有式I（AE）和式（II）的二氢苯并氮杂衍生物表示：其中指定为*的碳原子为R或S构型， X和R 1 -R 9如本文所定义。
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公开(公告)号：US20110077400A1
公开(公告)日：2011-03-31
申请号：US12995776
申请日：2009-06-04
申请人： Paul Lobben , Rulin Zhao , Bei Wang , Bang-Chi Chen , Shuang Liu , Min Hu , Yuh-Lin Allen Yang , Matthew Isherwood , Rasidul Amin , Wenge Cui
发明人： Paul Lobben , Rulin Zhao , Bei Wang , Bang-Chi Chen , Shuang Liu , Min Hu , Yuh-Lin Allen Yang , Matthew Isherwood , Rasidul Amin , Wenge Cui
IPC分类号： C07D403/10 , C07C211/26 , C07D217/02 , C07F5/02 , C07D237/02
CPC分类号： C07F5/04 , C07C215/20 , C07C217/58 , C07C223/02 , C07D217/04 , C07D237/20 , C07D401/04 , C07D413/10 , C07F5/022 , C07F5/025
摘要： Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form.
摘要翻译： 公开了制备四氢异喹啉的方法，可用于制备四氢异喹啉的中间体，制备这种中间体的方法和6 - [（4S）-2-甲基-4-（萘基）-1,2,3,4 - 四氢异喹啉-7-基]哒嗪-3-胺。 还公开了包含四氢异喹啉的药物组合物，使用四氢异喹啉处理抑郁症和其它病症的方法以及获得结晶形式的方法。
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5.发明申请ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN 审中-公开ARYL-和HETEROARYL取代的四氢苯并噻唑并用于阻断肾上腺素，多巴胺和丝氨酸蛋白酶公开(公告)号：US20090118260A1
公开(公告)日：2009-05-07
申请号：US12253170
申请日：2008-10-16
申请人： Bruce F. MOLINO , Shuang LIU , Aruna SAMBANDAM , Peter R. GUZZO , Min HU , Congxiang ZHA , Kassoum NACRO , David D. MANNING , Matthew L. ISHERWOOD , Kristen N. FLEMING , Wenge CUI , Richard E. OLSON
发明人： Bruce F. MOLINO , Shuang LIU , Aruna SAMBANDAM , Peter R. GUZZO , Min HU , Congxiang ZHA , Kassoum NACRO , David D. MANNING , Matthew L. ISHERWOOD , Kristen N. FLEMING , Wenge CUI , Richard E. OLSON
IPC分类号： A61K31/55 , C07D487/02 , C07D403/02
CPC分类号： C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
摘要翻译： 本发明的化合物由以下芳基 - 和杂芳基取代的四氢苯并吖庚因和具有式I（AE）和式（II）的二氢苯并氮杂衍生物表示：其中指定为*的碳原子为R或S构型， X和R 1 -R 9如本文所定义。
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6.发明授权Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin 有权芳基和杂芳基取代的四氢苯并氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取公开(公告)号：US07956050B2
公开(公告)日：2011-06-07
申请号：US11487884
申请日：2006-07-17
申请人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
发明人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
IPC分类号： A61P25/00 , A61K31/55 , C07D223/16
CPC分类号： C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
摘要翻译： 本发明的化合物由以下芳基 - 和杂芳基取代的四氢苯并吖庚因和具有式I（AE）和式（II）的二氢苯并氮杂衍生物表示：其中指定为*的碳原子为R或S构型， X和R 1 -R 9如本文所定义。
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7.发明申请ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZO-1,4-DIAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN 有权芳基取代四氢呋喃-1,4-二氮杂萘并用于阻断肾上腺素，多巴胺和丝氨酸蛋白酶公开(公告)号：US20100137287A1
公开(公告)日：2010-06-03
申请号：US12598882
申请日：2008-05-08
申请人： Peter R. Guzzo , Bruce F. Molino , Wenge Cui , Shuang Liu , Richard E. Olson
发明人： Peter R. Guzzo , Bruce F. Molino , Wenge Cui , Shuang Liu , Richard E. Olson
IPC分类号： A61K31/5513 , C07D243/14 , A61P25/00
CPC分类号： C07D243/14 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/14 , C07D471/04
摘要： The aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepine derivative compounds of the present invention are represented by formulae 1(A-D) having the following structure: where the substituents X and R1-R8 are as defined herein.
摘要翻译： 本发明的芳基 - 和杂芳基取代的四氢苯并-1,4-二氮杂衍生物化合物由具有以下结构的式1（A-D）表示：其中取代基X和R 1 -R 8如本文所定义。
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公开(公告)号：US08962648B2
公开(公告)日：2015-02-24
申请号：US13202544
申请日：2011-03-29
申请人： Yusuke Nakamura , Yo Matsuo , Shoji Hisada , Feryan Ahmed , Raymond Huntley , Zohreh Sajjadi-Hashemi , David M. Jenkins , Robert B. Kargbo , Wenge Cui , Polivina Jolicia F. Gauuan , Joel R. Walker , Helene Decornez , Mahender Gurram
发明人： Yusuke Nakamura , Yo Matsuo , Shoji Hisada , Feryan Ahmed , Raymond Huntley , Zohreh Sajjadi-Hashemi , David M. Jenkins , Robert B. Kargbo , Wenge Cui , Polivina Jolicia F. Gauuan , Joel R. Walker , Helene Decornez , Mahender Gurram
IPC分类号： A61K31/44 , A61K31/38 , C07D455/04 , C07D333/50 , C07D495/04 , C07D221/06 , C07D487/04 , C07D513/04 , C07D221/16 , C07D401/10
CPC分类号： C07D495/04 , C07D213/64 , C07D221/06 , C07D221/16 , C07D401/04 , C07D401/10 , C07D487/04 , C07D513/04 , C07D519/00
摘要： Tricyclic compounds are provided. These compounds are PBK inhibitors, and are useful for the treatment of PBK related diseases, including cancer.
摘要翻译： 提供三环化合物。 这些化合物是PBK抑制剂，可用于治疗包括癌症在内的PBK相关疾病。
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9.发明授权Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin 有权芳基和杂芳基取代的四氢苯并氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取公开(公告)号：US08791101B2
公开(公告)日：2014-07-29
申请号：US12917066
申请日：2010-11-01
申请人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
发明人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
IPC分类号： A61K31/55 , C07D401/04
CPC分类号： C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
摘要翻译： 本发明的化合物由以下芳基 - 和杂芳基取代的四氢苯并吖庚因和具有式I（AE）和式（II）的二氢苯并氮杂衍生物表示：其中指定为*的碳原子为R或S构型， X和R 1 -R 9如本文所定义。
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公开(公告)号：US08420811B2
公开(公告)日：2013-04-16
申请号：US12995776
申请日：2009-06-04
申请人： Paul Lobben , Rulin Zhao , Bei Wang , Bang-Chi Chen , Shuang Liu , Min Hu , Yuh-Lin Allen Yang , Matthew Isherwood , Rasidul Amin , Wenge Cui
发明人： Paul Lobben , Rulin Zhao , Bei Wang , Bang-Chi Chen , Shuang Liu , Min Hu , Yuh-Lin Allen Yang , Matthew Isherwood , Rasidul Amin , Wenge Cui
IPC分类号： C07D401/04 , A61P25/24
CPC分类号： C07F5/04 , C07C215/20 , C07C217/58 , C07C223/02 , C07D217/04 , C07D237/20 , C07D401/04 , C07D413/10 , C07F5/022 , C07F5/025
摘要： Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form. One such intermediate has the following structure:
摘要翻译： 公开了制备四氢异喹啉的方法，可用于制备四氢异喹啉的中间体，制备这种中间体的方法和6 - [（4S）-2-甲基-4-（萘基）-1,2,3,4 - 四氢异喹啉-7-基]哒嗪-3-胺。 还公开了包含四氢异喹啉的药物组合物，使用四氢异喹啉处理抑郁症和其它病症的方法以及获得结晶形式的方法。 一个这样的中间体具有以下结构：
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