Invention Grant
- Patent Title: Methods for inhibition of lymphangiogenesis and tumor metastasis
- Patent Title (中): 抑制淋巴管生成和肿瘤转移的方法
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Application No.: US12223380Application Date: 2007-02-05
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Publication No.: US08808698B2Publication Date: 2014-08-19
- Inventor: Judith Varner , Barbara Garmy-Susini
- Applicant: Judith Varner , Barbara Garmy-Susini
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Medlen & Carroll, LLP
- International Application: PCT/US2007/003205 WO 20070205
- International Announcement: WO2007/092471 WO 20070816
- Main IPC: A61K31/00
- IPC: A61K31/00 ; A61K38/00 ; A61K39/395 ; A61K49/00
Abstract:
The present invention is directed to compositions and methods for inhibiting the development of new lymphatic vessels, and for inhibiting tumor cell dissemination through the lymphatics. In preferred embodiments, the present invention utilizes agents that inhibit the specific binding of integrin alpha4beta1 (α4β1, VLA-4) to one or more of its ligands. The invention further relates to methods for screening test compounds for their ability to inhibit undesirable lymphangiogenesis and/or tumor metastasis.
Public/Granted literature
- US20100055089A1 Methods for Inhibition of Lymphangiogenesis and Tumor Metastasis Public/Granted day:2010-03-04
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