公开(公告)号：US08808698B2

公开(公告)日：2014-08-19

申请号：US12223380

申请日：2007-02-05

Applicant: Judith Varner ,  Barbara Garmy-Susini

Inventor： Judith Varner ,  Barbara Garmy-Susini

IPC: A61K31/00 ,  A61K38/00 ,  A61K39/395 ,  A61K49/00

CPC classification number: C07K16/2842 ,  A61K2039/505 ,  C07K2317/76

Abstract: The present invention is directed to compositions and methods for inhibiting the development of new lymphatic vessels, and for inhibiting tumor cell dissemination through the lymphatics. In preferred embodiments, the present invention utilizes agents that inhibit the specific binding of integrin alpha4beta1 (α4β1, VLA-4) to one or more of its ligands. The invention further relates to methods for screening test compounds for their ability to inhibit undesirable lymphangiogenesis and/or tumor metastasis.

Abstract translation: 本发明涉及用于抑制新淋巴管的发育并抑制通过淋巴管的肿瘤细胞传播的组合物和方法。 在优选的实施方案中，本发明使用抑制整联蛋白α4β1（α4和bgr1，VLA-4）与其一种或多种配体的特异性结合的试剂。 本发明还涉及用于筛选测试化合物以抑制不希望的淋巴管生成和/或肿瘤转移的能力的方法。

公开(公告)号：US20100055089A1

公开(公告)日：2010-03-04

申请号：US12223380

申请日：2007-02-05

Applicant: Judith Varner ,  Barbara Garmy-Susini

Inventor： Judith Varner ,  Barbara Garmy-Susini

IPC: A61K39/395 ,  A61K38/00 ,  A61K31/7088 ,  G01N33/567 ,  C12N5/02

CPC classification number: C07K16/2842 ,  A61K2039/505 ,  C07K2317/76

Abstract: The present invention is directed to compositions and methods for inhibiting the development of new lymphatic vessels, and for inhibiting tumor cell dissemination through the lymphatics. In preferred embodiments, the present invention utilizes agents that inhibit the specific binding of integrin alpha4beta1 (α4β1, VLA-4) to one or more of its ligands. The invention further relates to methods for screening test compounds for their ability to inhibit undesirable lymphangiogenesis and/or tumor metastasis.

Abstract translation: 本发明涉及用于抑制新淋巴管的发育并抑制通过淋巴管的肿瘤细胞传播的组合物和方法。 在优选的实施方案中，本发明使用抑制整联蛋白α4β1（α4和bgr1，VLA-4）与其一种或多种配体的特异性结合的试剂。 本发明还涉及用于筛选测试化合物以抑制不希望的淋巴管生成和/或肿瘤转移的能力的方法。