公开(公告)号：US20050129681A1

公开(公告)日：2005-06-16

申请号：US10485758

申请日：2002-08-01

Applicant: Judith Varner

Inventor： Judith Varner

IPC: A61K38/39 ,  A61K39/395 ,  A61K48/00 ,  C07K16/18 ,  C07K16/28 ,  G01N33/50 ,  G01N33/68

CPC classification number: G01N33/5011 ,  A61K38/39 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2842 ,  C07K2317/76 ,  G01N33/6893 ,  G01N2333/70546 ,  G01N2333/7055 ,  G01N2500/04 ,  G01N2500/10

Abstract: The invention provides methods for detecting and inhibiting angiogenesis, endothelial cell adhesion, and endothelial cell migration using agents which inhibit the specific binding of integrin α4β1 to one or more of its ligands. The invention further provides methods for screening test compounds for their ability to inhibit angiogenesis, endothelial cell adhesion, or endothelial cell migration by employing agents which inhibit the specific binding of integrin α4β1 to one or more of its ligands. The invention additionally relates to methods for isolating endothelial progenitor cells which express integrin α4β1. The methods of the invention are useful in, for example, diagnosing and inhibiting pathological conditions that are associated with angiogenesis, endothelial cell adhesion, and/or endothelial cell migration. The invention's methods are also useful in isolating endothelial progenitor cells, and in determining the mechanisms that underlie angiogenesis, development, wound healing, and the function of the female reproductive system.

Abstract translation: 本发明提供使用抑制整合素α4β1与其一种或多种配体的特异性结合的试剂检测和抑制血管发生，内皮细胞粘附和内皮细胞迁移的方法。 本发明还提供了通过使用抑制整合素α4β1与其一种或多种配体的特异性结合的试剂来筛选测试化合物以抑制血管发生，内皮细胞粘附或内皮细胞迁移的能力的方法。 本发明还涉及用于分离表达整合素α4β1的内皮祖细胞的方法。 本发明的方法可用于例如诊断和抑制与血管发生，内皮细胞粘附和/或内皮细胞迁移相关的病理状况。 本发明的方法也可用于分离内皮祖细胞，以及在确定血管生成，发育，伤口愈合以及女性生殖系统功能的基础上的机制。

公开(公告)号：US08808698B2

公开(公告)日：2014-08-19

申请号：US12223380

申请日：2007-02-05

Applicant: Judith Varner ,  Barbara Garmy-Susini

Inventor： Judith Varner ,  Barbara Garmy-Susini

IPC: A61K31/00 ,  A61K38/00 ,  A61K39/395 ,  A61K49/00

CPC classification number: C07K16/2842 ,  A61K2039/505 ,  C07K2317/76

Abstract: The present invention is directed to compositions and methods for inhibiting the development of new lymphatic vessels, and for inhibiting tumor cell dissemination through the lymphatics. In preferred embodiments, the present invention utilizes agents that inhibit the specific binding of integrin alpha4beta1 (α4β1, VLA-4) to one or more of its ligands. The invention further relates to methods for screening test compounds for their ability to inhibit undesirable lymphangiogenesis and/or tumor metastasis.

Abstract translation: 本发明涉及用于抑制新淋巴管的发育并抑制通过淋巴管的肿瘤细胞传播的组合物和方法。 在优选的实施方案中，本发明使用抑制整联蛋白α4β1（α4和bgr1，VLA-4）与其一种或多种配体的特异性结合的试剂。 本发明还涉及用于筛选测试化合物以抑制不希望的淋巴管生成和/或肿瘤转移的能力的方法。

公开(公告)号：US20100055089A1

公开(公告)日：2010-03-04

申请号：US12223380

申请日：2007-02-05

Applicant: Judith Varner ,  Barbara Garmy-Susini

Inventor： Judith Varner ,  Barbara Garmy-Susini

IPC: A61K39/395 ,  A61K38/00 ,  A61K31/7088 ,  G01N33/567 ,  C12N5/02

CPC classification number: C07K16/2842 ,  A61K2039/505 ,  C07K2317/76

Abstract: The present invention is directed to compositions and methods for inhibiting the development of new lymphatic vessels, and for inhibiting tumor cell dissemination through the lymphatics. In preferred embodiments, the present invention utilizes agents that inhibit the specific binding of integrin alpha4beta1 (α4β1, VLA-4) to one or more of its ligands. The invention further relates to methods for screening test compounds for their ability to inhibit undesirable lymphangiogenesis and/or tumor metastasis.

Abstract translation: 本发明涉及用于抑制新淋巴管的发育并抑制通过淋巴管的肿瘤细胞传播的组合物和方法。 在优选的实施方案中，本发明使用抑制整联蛋白α4β1（α4和bgr1，VLA-4）与其一种或多种配体的特异性结合的试剂。 本发明还涉及用于筛选测试化合物以抑制不希望的淋巴管生成和/或肿瘤转移的能力的方法。

公开(公告)号：US20060241067A1

公开(公告)日：2006-10-26

申请号：US10518181

申请日：2003-06-25

Applicant: Judith Varner ,  Manjiri Bakre ,  Hui Jin

Inventor： Judith Varner ,  Manjiri Bakre ,  Hui Jin

IPC: A61K48/00

CPC classification number: A61K48/005 ,  A61K38/164 ,  A61K38/45 ,  C12N9/1205 ,  Y02A50/471

Abstract: The invention relates to methods for detecting and inhibiting angiogenesis, cell migration, cell adhesion, and/or cell survival in endothelial and non-endothelial cells as well as in normal and tumor cells. The invention further relates to methods for screening test compounds for their ability to inhibit angiogenesis, cell migration, cell adhesion, and/or cell survival.

Abstract translation: 本发明涉及在内皮和非内皮细胞以及正常和肿瘤细胞中检测和抑制血管发生，细胞迁移，细胞粘附和/或细胞存活的方法。 本发明还涉及用于筛选测试化合物以抑制血管发生，细胞迁移，细胞粘附和/或细胞存活的能力的方法。