发明授权
- 专利标题： Dicarboxylic acid derivatives as S1P1 receptor agonists
- 专利标题（中）： 二羧酸衍生物作为S1P1受体激动剂
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申请号： US12664718申请日： 2008-06-16
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公开(公告)号： US08809539B2公开(公告)日： 2014-08-19
- 发明人: Marc Capet , Nicolas Levoin , Isabelle Berrebi-Bertrand , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte , Jayraj Dilipbhai Aradhye , Muthukumaran Natarajan Pillai , Bhavesh Mohanbhai Panchal , Jignesh Kantilal Jivani , Biswajit Samanta , Ranjan Kumar Pal , Rajamannar Thennati
- 申请人： Marc Capet , Nicolas Levoin , Isabelle Berrebi-Bertrand , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte , Jayraj Dilipbhai Aradhye , Muthukumaran Natarajan Pillai , Bhavesh Mohanbhai Panchal , Jignesh Kantilal Jivani , Biswajit Samanta , Ranjan Kumar Pal , Rajamannar Thennati
- 申请人地址： FR Paris IN Mumbai
- 专利权人： Bioprojet,Sun Pharma Advanced Research Company Ltd
- 当前专利权人： Bioprojet,Sun Pharma Advanced Research Company Ltd
- 当前专利权人地址： FR Paris IN Mumbai
- 代理机构： Stites & Harbison,. PLLC.
- 代理商 B. Aaron Schulman, Esq.
- 优先权： EP07290748 20070615
- 国际申请： PCT/EP2008/057571 WO 20080616
- 国际公布： WO2008/152149 WO 20081218
- 主分类号： C07D211/18
- IPC分类号： C07D211/18 ; A61K31/445 ; C07D413/10
摘要：
The present invention relates to new compounds of formula (I) possessing agonistic activity at sphingosine-1-phosphate (S1P) receptors, their process of preparation and their use as immunosuppressive agents. The invention is also directed to pharmaceutical compositions containing these compounds and use of these compounds for treatment/prevention of immune mediated diseases and conditions or inflammatory diseases and conditions.