发明授权
US08815562B2 Biosynthetic pathway for heterologous expression of a nonribosomal peptide synthetase drug and analogs
有权
用于异源表达非核糖体肽合成酶药物和类似物的生物合成途径
- 专利标题： Biosynthetic pathway for heterologous expression of a nonribosomal peptide synthetase drug and analogs
- 专利标题（中）： 用于异源表达非核糖体肽合成酶药物和类似物的生物合成途径
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申请号： US13640815申请日： 2011-04-15
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公开(公告)号： US08815562B2公开(公告)日： 2014-08-26
- 发明人: David H. Sherman , Garth D. Ehrlich , Benjamin Janto , Robert M. Williams , Christopher M. Rath
- 申请人： David H. Sherman , Garth D. Ehrlich , Benjamin Janto , Robert M. Williams , Christopher M. Rath
- 申请人地址： US MI Ann Arbor US PA Pittsburgh US CO Fort Collins
- 专利权人： The Regenys of the University of Michigan,Allegheny-Singer Research Institute,Colorado State University Research Foundation
- 当前专利权人： The Regenys of the University of Michigan,Allegheny-Singer Research Institute,Colorado State University Research Foundation
- 当前专利权人地址： US MI Ann Arbor US PA Pittsburgh US CO Fort Collins
- 代理机构： Marshall, Gerstein & Borun LLP
- 国际申请： PCT/US2011/032796 WO 20110415
- 国际公布： WO2011/130719 WO 20111020
- 主分类号： C12N9/88
- IPC分类号： C12N9/88 ; C12N15/00 ; C12N1/20 ; C07K1/00 ; C07H21/04 ; C12P17/18 ; C12N15/52
摘要：
The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.
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