发明授权
- 专利标题: 2'-O-modified RNA
- 专利标题(中): 2'-O-修饰的RNA
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申请号: US13990441申请日: 2011-11-28
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公开(公告)号: US08822671B2公开(公告)日: 2014-09-02
- 发明人: Mamoru Shimizu , Takeshi Wada , Kouichiro Arai
- 申请人: Mamoru Shimizu , Takeshi Wada , Kouichiro Arai
- 申请人地址: JP Tokyo JP Okinawa
- 专利权人: The University of Tokyo,Chiralgen, Ltd.
- 当前专利权人: The University of Tokyo,Chiralgen, Ltd.
- 当前专利权人地址: JP Tokyo JP Okinawa
- 代理机构: Osha Liang LLP
- 国际申请: PCT/JP2011/077313 WO 20111128
- 国际公布: WO2012/073857 WO 20120607
- 主分类号: C07H21/02
- IPC分类号: C07H21/02 ; C07H19/10 ; C07H23/00 ; C07H19/06 ; C07H1/00 ; C07H19/067 ; C07H19/167
摘要:
A 2′-modified ribonucleoside having an alkoxymethyl protective group can be imparted with a high duplex-forming ability by introducing, as a substituent, a halogen atom into the protective group moiety. A modified form of RNA having a halogen-substituted alkoxymethyl protective group exhibits a high duplex-forming ability that is comparable to the duplex-forming ability of a 2′-O-methyl modified nucleic acid.
公开/授权文献
- US20130253178A1 2'-O-MODIFIED RNA 公开/授权日:2013-09-26
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