利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

161 条记录 (耗时 0.029 秒)

    2'-O-MODIFIED RNA
    2.
    发明申请
    2'-O-MODIFIED RNA 有权
    2'-O修饰的RNA

    公开(公告)号：US20130253178A1

    公开(公告)日：2013-09-26

    申请号：US13990441

    申请日：2011-11-28

    申请人： Mamoru Shimizu ,  Takeshi Wada ,  Kouichiro Arai

    发明人： Mamoru Shimizu ,  Takeshi Wada ,  Kouichiro Arai

    IPC分类号： C07H21/02 ,  C07H19/10 ,  C07H19/06 ,  C07H1/00

    CPC分类号： C07H21/02 ,  C07H1/00 ,  C07H19/06 ,  C07H19/067 ,  C07H19/10 ,  C07H19/167 ,  C07H23/00 ,  Y02P20/55

    摘要： [Problem]To provide a 2′-modified ribonucleoside or the like which has a high duplex-forming ability.[Solution]The present invention is generally based on the finding in embodiments that a modified form of a ribonucleoside or the like having an alkoxymethyl protective group can be imparted with a high duplex-forming ability by introducing, as a substituent, a halogen atom into the protective group moiety. As explained before, a modified form of RNA having an alkoxymethyl protective group has a low duplex-forming ability. A modified form of RNA having a halogen-substituted alkoxymethyl protective group, however, exhibits a high duplex-forming ability that is comparable to the duplex-forming ability of a 2′-O-methyl modified nucleic acid.

    摘要翻译： [问题]提供具有高双相形成能力的2'-修饰的核糖核苷等。 [解决方案]本发明通常基于实施方案中发现，通过将卤素原子引入作为取代基的卤素原子，可以赋予具有烷氧基甲基保护基的核糖核苷等的修饰形式具有高双相形成能力 保护基团部分。 如前所述，具有烷氧基甲基保护基的RNA的修饰形式具有低的双链体形成能力。 然而，具有卤素取代的烷氧基甲基保护基的RNA的修饰形式表现出与2'-O-甲基修饰的核酸的双链体形成能力相当的高双相形成能力。

    Protective group for synthesis of RNA and derivative
    3.
    发明授权
    Protective group for synthesis of RNA and derivative 有权
    用于合成RNA和衍生物的保护基团

    公开(公告)号：US08470987B2

    公开(公告)日：2013-06-25

    申请号：US12882390

    申请日：2010-09-15

    申请人： Takeshi Wada ,  Mamoru Shimizu

    发明人： Takeshi Wada ,  Mamoru Shimizu

    IPC分类号： C07H19/00 ,  C07H21/00

    CPC分类号： C07F9/65586 ,  C07F9/65616 ,  C07F9/65844 ,  C07H19/067 ,  C07H19/167 ,  Y02P20/55

    摘要： A protective group represented by the following general formula (I) (the oxygen atom attached with * represents oxygen atom of 2′-hydroxyl group of a ribonucleoside, a ribonucleotide or a derivative thereof; R1 and R2 both represent hydrogen atom, or represent a halogen atom, a C1-6 alkyl group, or a C1-6 halo-substituted alkyl group; R3 and R4 represent hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 halo-substituted alkyl group; and R5 and R6 represent a halogen atom, a C1-6 halo-substituted alkyl group, cyano group, nitro group, or the like), which is stable under the reaction conditions of the nucleic acid synthetic cycles and has little steric hindrance, and can be removed under mild conditions using fluoride ions as a base.

    摘要翻译： 由下述通式（I）表示的保护基（与*相连的氧原子表示核糖核苷，2核苷酸或其衍生物的2'-羟基的氧原子; R1和R2均表示氢原子， 卤素原子，C 1-6烷基或C 1-6卤素取代的烷基; R 3和R 4表示氢原子，卤素原子，C 1-6烷基或C 1-6卤素取代的烷基; R5和R6表示卤素原子，C1-6卤代烷基，氰基，硝基等），其在核酸合成循环的反应条件下是稳定的，几乎没有空间位阻， 可以在温和条件下使用氟离子作为基底去除。

    METHOD FOR THE SYNTHESIS OF PHOSPHORUS ATOM MODIFIED NUCLEIC ACIDS
    4.
    发明申请
    METHOD FOR THE SYNTHESIS OF PHOSPHORUS ATOM MODIFIED NUCLEIC ACIDS 有权
    磷化氢修饰核酸的合成方法

    公开(公告)号：US20110294124A1

    公开(公告)日：2011-12-01

    申请号：US13131591

    申请日：2009-12-02

    申请人： Takeshi Wada ,  Mamoru Shimizu

    发明人： Takeshi Wada ,  Mamoru Shimizu

    IPC分类号： C12Q1/68 ,  C07H21/00 ,  G01N21/76 ,  C12P19/34 ,  G01N33/53 ,  G01N21/64

    CPC分类号： C07H21/00 ,  C07H1/00

    摘要： Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H-phophonate moiety with a nucleoside/nucleotide.

    摘要翻译： 本文描述了合成包含手性X-膦酸酯部分的磷原子修饰的核酸的方法。 本文描述的方法通过包含化学稳定的H-膦酸酯部分与核苷/核苷酸的非手性分子的不对称反应提供具有高度对映纯度的骨架修饰的核酸。

    Method for the synthesis of phosphorus atom modified nucleic acids
    7.
    发明授权
    Method for the synthesis of phosphorus atom modified nucleic acids 有权
    磷原子修饰核酸合成方法

    公开(公告)号：US09394333B2

    公开(公告)日：2016-07-19

    申请号：US13131591

    申请日：2009-12-02

    申请人： Takeshi Wada ,  Mamoru Shimizu

    发明人： Takeshi Wada ,  Mamoru Shimizu

    IPC分类号： C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： C07H21/00 ,  C07H1/00

    摘要： Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H-phophonate moiety with a nucleoside/nucleotide.

    摘要翻译： 本文描述了合成包含手性X-膦酸酯部分的磷原子修饰的核酸的方法。 本文描述的方法通过包含化学稳定的H-膦酸酯部分与核苷/核苷酸的非手性分子的不对称反应提供具有高度对映纯度的骨架修饰的核酸。

    Metal member manufacturing method and metal member
    8.
    发明授权
    Metal member manufacturing method and metal member 有权
    金属构件制造方法和金属构件

    公开(公告)号：US09279186B2

    公开(公告)日：2016-03-08

    申请号：US13574854

    申请日：2010-10-22

    申请人： Hidemi Kato ,  Takeshi Wada ,  Kunio Yubuta ,  Akihisa Inoue

    发明人： Hidemi Kato ,  Takeshi Wada ,  Kunio Yubuta ,  Akihisa Inoue

    IPC分类号： C23F4/04 ,  C23C26/02 ,  C23F1/00 ,  C22B9/02 ,  C22B26/22

    CPC分类号： C23C26/02 ,  B22F2998/00 ,  C22B9/02 ,  C22B26/22 ,  C23F1/00 ,  C23F4/04 ,  Y02P10/234 ,  Y10T428/12479 ,  C22C1/0425 ,  C22C1/0433 ,  C22C33/02

    摘要： A metallic material containing both a second constituent and a third constituent having positive and negative heats of mixing relative to a first constituent, respectively, and including a compound, an alloy or a nonequilibrium alloy having a melting point that is higher than the solidifying point of a metal bath made of the first constituent is placed in the metal bath. The metal bath is controlled to a temperature lower than a minimum value of a liquidus temperature within a range of compositional variations in which the amount of the third constituent in the metallic material decreases down to a point where the metallic material becomes substantially the second constituent so that the third constituent is selectively dissolved into the metal bath.

    摘要翻译： 一种含有第二成分和第三成分的金属材料，分别具有相对于第一成分的正和负的混合热，并且包括熔点高于凝固点的化合物，合金或非平衡合金 将由第一成分制成的金属浴放置在金属浴中。 将金属浴控制在低于液相线温度的最小值的温度范围内，其中金属材料中的第三成分的量减少到金属材料基本上变成第二成分的程度 第三组分选择性地溶解到金属浴中。

    ILLUMINATING DEVICE AND DISPLAY DEVICE
    10.
    发明申请
    ILLUMINATING DEVICE AND DISPLAY DEVICE 审中-公开
    照明设备和显示设备

    公开(公告)号：US20120320623A1

    公开(公告)日：2012-12-20

    申请号：US13581381

    申请日：2011-03-01

    申请人： Takeshi Wada

    发明人： Takeshi Wada

    IPC分类号： F21V8/00

    CPC分类号： G02F1/133615 ,  G02B6/0088 ,  G02B6/009

    摘要： An illuminating device includes a light guide plate; a light source that is located opposite at least two adjacent end faces of four end faces of the light guide plate; and a chassis that has an opening through which light emanating from a light emission surface of the light guide plate passes. At least one optical sheet that includes a corner portion with an interior angle of greater than 90 degrees in a position corresponding to a corner portion of the light guide plate that is sandwiched between the two end faces opposite the light source is disposed between the light emission surface of the light guide plate and the chassis.

    摘要翻译： 照明装置包括导光板; 光源，其与所述导光板的四个端面的至少两个相邻的端面相对; 以及具有从导光板的发光面发出的光通过的开口的底架。 至少一个光学片包括在对应于导光板的夹在与光源相对的两个端面之间的导光板的角部的位置处具有大于90度的内角的角部， 导光板和底盘的表面。