Invention Grant
US08829109B2 Cleavable modifications to reducible poly(amido ethylenimine)s to enhance nucleotide delivery
有权
可还原的聚（酰氨基亚乙基亚胺）的可修饰修饰以增强核苷酸的传递
- Patent Title: Cleavable modifications to reducible poly(amido ethylenimine)s to enhance nucleotide delivery
- Patent Title (中): 可还原的聚（酰氨基亚乙基亚胺）的可修饰修饰以增强核苷酸的传递
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Application No.: US12266980Application Date: 2008-11-07
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Publication No.: US08829109B2Publication Date: 2014-09-09
- Inventor: James W. Yockman , Jonathan Brumbach , Lane V. Christensen , Sung Wan Kim
- Applicant: James W. Yockman , Jonathan Brumbach , Lane V. Christensen , Sung Wan Kim
- Applicant Address: US UT Salt Lake City
- Assignee: University of Utah Research Foundation
- Current Assignee: University of Utah Research Foundation
- Current Assignee Address: US UT Salt Lake City
- Agency: Clayton, Howarth & Cannon, P.C.
- Main IPC: A61K47/48
- IPC: A61K47/48 ; C08G63/48 ; C08G63/91 ; C08L89/00 ; C12N15/00 ; C08G65/334 ; C08G73/02 ; C08G65/333 ; C08G65/332
Abstract:
Improved poly(amido ethylenimine) copolymers for gene delivery are disclosed. One illustrative embodiment includes polyethylene glycol (PEG) covalently bonded to a branched poly(triethyenetetramine/cystamine bisacrylamide) copolymer (poly(TETA/CBA)). The polyethylene glycol can be linear or branched. Another illustrative embodiment includes an RGD peptide covalently bonded to the poly(TETA/CBA)-PEG conjugate. Still another illustrative embodiment includes a method of using these compositions for transfecting a cell with a nucleic acid.
Public/Granted literature
- US20090142842A1 CLEAVABLE MODIFICATIONS TO REDUCIBLE POLY(AMIDO ETHYLENIMINE)S TO ENHANCE NUCLEOTIDE DELIVERY Public/Granted day:2009-06-04
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